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Reep2 receptor accessory protein 2 [ Mus musculus (house mouse) ]

Gene ID: 225362, updated on 11-Apr-2024

Summary

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Official Symbol
Reep2provided by MGI
Official Full Name
receptor accessory protein 2provided by MGI
Primary source
MGI:MGI:2385070
See related
Ensembl:ENSMUSG00000038555 AllianceGenome:MGI:2385070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables taste receptor binding activity. Involved in regulation of intracellular transport. Acts upstream of or within protein transport into membrane raft; sensory perception of bitter taste; and sensory perception of sweet taste. Located in endoplasmic reticulum membrane. Is integral component of plasma membrane. Is expressed in central nervous system; eye; ganglia; incisor; and testis. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72. Orthologous to human REEP2 (receptor accessory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 71.0), testis adult (RPKM 55.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.75 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34973642..34980516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34840589..34847463)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 12191 Neighboring gene family with sequence similarity 53, member C Neighboring gene predicted gene 3561 Neighboring gene STARR-positive B cell enhancer ABC_E7576 Neighboring gene STARR-seq mESC enhancer starr_44212 Neighboring gene KDM3B lysine (K)-specific demethylase 3B Neighboring gene STARR-seq mESC enhancer starr_44215 Neighboring gene STARR-positive B cell enhancer ABC_E5650 Neighboring gene STARR-positive B cell enhancer ABC_E8958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35020809-35020992 Neighboring gene early growth response 1 Neighboring gene predicted gene, 54018

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. Björk S, et al. PLoS One, 2013. PMID 24098485, Free PMC Article
  2. REEP2 enhances sweet receptor function by recruitment to lipid rafts. Ilegems E, et al. J Neurosci, 2010 Oct 13. PMID 20943918, Free PMC Article
  3. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
  4. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28827

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport into membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of intracellular transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sensory perception of bitter taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sweet taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
NOT located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
receptor expression-enhancing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204914.1 → NP_001191843.1  receptor expression-enhancing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001191843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BB709634, BC020184, CX216997, EU555417
    UniProtKB/TrEMBL
    C1IE02
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  2. NM_144865.2 → NP_659114.2  receptor expression-enhancing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_659114.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB709634, BC020184, CX216997
    Consensus CDS
    CCDS29135.1
    UniProtKB/Swiss-Prot
    Q8VCD6
    Related
    ENSMUSP00000036065.8, ENSMUST00000043484.8
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34973642..34980516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCD6.2 GenPept UniProtKB/Swiss-Prot:Q8VCD6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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