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Fam13b family with sequence similarity 13, member B [ Mus musculus (house mouse) ]

Gene ID: 225358, updated on 5-Mar-2024

Summary

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Official Symbol
Fam13bprovided by MGI
Official Full Name
family with sequence similarity 13, member Bprovided by MGI
Primary source
MGI:MGI:2447834
See related
Ensembl:ENSMUSG00000036501 AllianceGenome:MGI:2447834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610024E20Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including brain; endocrine gland; genitourinary system; hemolymphoid system gland; and intestine. Orthologous to human FAM13B (family with sequence similarity 13 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.4), whole brain E14.5 (RPKM 11.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fam13b in Genome Data Viewer
Location:
18 B1; 18 18.69 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34573624..34656096, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34440571..34523047, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene polycystic kidney disease 2-like 2 Neighboring gene SET translocation pseudogene Neighboring gene STARR-seq mESC enhancer starr_44201 Neighboring gene STARR-seq mESC enhancer starr_44203 Neighboring gene STARR-seq mESC enhancer starr_44204 Neighboring gene STARR-seq mESC enhancer starr_44205 Neighboring gene STARR-seq mESC enhancer starr_44207 Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene STARR-positive B cell enhancer mm9_chr18:34732422-34732722 Neighboring gene NME/NM23 family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37079

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM13B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417763.1 → NP_001404692.1  protein FAM13B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115305

  2. NM_001417764.1 → NP_001404693.1  protein FAM13B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115305

  3. NM_001417765.1 → NP_001404694.1  protein FAM13B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115305

  4. NM_001417768.1 → NP_001404697.1  protein FAM13B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115305

  5. NM_001417769.1 → NP_001404698.1  protein FAM13B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115305

  6. NM_001417770.1 → NP_001404699.1  protein FAM13B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115305

  7. NM_001417771.1 → NP_001404700.1  protein FAM13B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC115305

  8. NM_001417772.1 → NP_001404701.1  protein FAM13B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC115305

  9. NM_001417773.1 → NP_001404702.1  protein FAM13B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC115305

  10. NM_001417775.1 → NP_001404704.1  protein FAM13B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC115305

  11. NM_001417776.1 → NP_001404705.1  protein FAM13B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC115305

  12. NM_146084.2 → NP_666196.1  protein FAM13B isoform 1

    See identical proteins and their annotated locations for NP_666196.1

    Status: VALIDATED

    Source sequence(s)
    AC115305
    Consensus CDS
    CCDS29128.1
    UniProtKB/Swiss-Prot
    Q8K2H3
    Related
    ENSMUSP00000038199.7, ENSMUST00000040506.8
    Conserved Domains (1) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34573624..34656096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525849.4 → XP_006525912.1  protein FAM13B isoform X1

    See identical proteins and their annotated locations for XP_006525912.1

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    pfam11719
    Location:566 → 645
    Drc1-Sld2; DNA replication and checkpoint protein

  2. XM_036161109.1 → XP_036017002.1  protein FAM13B isoform X16

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:733 → 772
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  3. XM_036161108.1 → XP_036017001.1  protein FAM13B isoform X14

    Conserved Domains (1) summary
    cl26235
    Location:555 → 594
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  4. XM_030250433.1 → XP_030106293.1  protein FAM13B isoform X12

  5. XM_006525854.2 → XP_006525917.1  protein FAM13B isoform X9

    See identical proteins and their annotated locations for XP_006525917.1

  6. XM_030250432.1 → XP_030106292.1  protein FAM13B isoform X12

  7. XM_036161106.1 → XP_036016999.1  protein FAM13B isoform X11

    Conserved Domains (1) summary
    cl26235
    Location:635 → 674
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  8. XM_006525853.2 → XP_006525916.1  protein FAM13B isoform X9

    See identical proteins and their annotated locations for XP_006525916.1

  9. XM_036161105.1 → XP_036016998.1  protein FAM13B isoform X7

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:765 → 804
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  10. XM_017317886.1 → XP_017173375.1  protein FAM13B isoform X5

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    pfam11719
    Location:544 → 621
    Drc1-Sld2; DNA replication and checkpoint protein

  11. XM_036161104.1 → XP_036016997.1  protein FAM13B isoform X6

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:787 → 826
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  12. XM_006525852.3 → XP_006525915.1  protein FAM13B isoform X4

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    pfam11719
    Location:566 → 645
    Drc1-Sld2; DNA replication and checkpoint protein

  13. XM_006525858.2 → XP_006525921.1  protein FAM13B isoform X15

    See identical proteins and their annotated locations for XP_006525921.1

  14. XM_006525857.2 → XP_006525920.1  protein FAM13B isoform X15

    See identical proteins and their annotated locations for XP_006525920.1

  15. XM_006525855.4 → XP_006525918.1  protein FAM13B isoform X10

    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    pfam11719
    Location:566 → 661
    Drc1-Sld2; DNA replication and checkpoint protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2H3.1 GenPept UniProtKB/Swiss-Prot:Q8K2H3

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