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Hrh4 histamine receptor H4 [ Mus musculus (house mouse) ]

Gene ID: 225192, updated on 11-Apr-2024

Summary

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Official Symbol
Hrh4provided by MGI
Official Full Name
histamine receptor H4provided by MGI
Primary source
MGI:MGI:2429635
See related
Ensembl:ENSMUSG00000037346 AllianceGenome:MGI:2429635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105
Summary
Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and inflammatory response. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Orthologous to human HRH4 (histamine receptor H4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.0) and spleen adult (RPKM 0.1) See more
Orthologs
human all
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Genomic context

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See Hrh4 in Genome Data Viewer
Location:
18 A1; 18 6.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13140039..13156758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (13006982..13023701)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene impact, RWD domain protein Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 36563

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Interplay between Histamine H(4) Receptor and the Kidney Function: The Lesson from H(4) Receptor Knockout Mice. Verta R, et al. Biomolecules, 2021 Oct 15. PMID 34680152, Free PMC Article
  2. The Novel H(4)R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma. Balbino AM, et al. Cell Physiol Biochem, 2020 Nov 21. PMID 33216475
  3. Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue. Zhao YX, et al. Am J Physiol Endocrinol Metab, 2019 Dec 1. PMID 31550180
  4. In vivo Evidence for Partial Activation of Eosinophils via the Histamine H(4)-Receptor: Adoptive Transfer Experiments Using Eosinophils From H(4)R(-/-) and H(4)R(+/+) Mice. Schirmer B, et al. Front Immunol, 2018. PMID 30319608, Free PMC Article
  5. Effects of a histamine H(4) receptor antagonist on cisplatin-induced anorexia in mice. Yamamoto K, et al. Neurosci Lett, 2018 May 29. PMID 29655943

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice.
    Title: The Interplay between Histamine H(4) Receptor and the Kidney Function: The Lesson from H(4) Receptor Knockout Mice.
  2. The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
    Title: The Histamine H(4) Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A(3) Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
  3. The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
    Title: The Novel H(4)R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
  4. Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
    Title: Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
  5. Findings show an effective role of HrH4 in adipose tissue browning.
    Title: Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue.
  6. Study using adoptive transfer of eosinophils from H4R-deficient and H4R-competentmice to dextran sodium sulfate-induced colitis in IL-5-deficient mice demonstrate that as well as in vitro, also in vivo histamine via the H4R only partially activates eosinophils.
    Title: In vivo Evidence for Partial Activation of Eosinophils via the Histamine H(4)-Receptor: Adoptive Transfer Experiments Using Eosinophils From H(4)R(-/-) and H(4)R(+/+) Mice.
  7. Rac1 and Rac2 have distinct and essential roles in intracellular signaling downstream of H4 receptor-PI3K in histamine-induced chemotaxis of mast cells
    Title: Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H(4) Receptor-Mediated Chemotaxis of Mast Cells.
  8. Study results indicate that persistent ERK activation via the histamine H4 receptor in spinal neurons underlies dinitrofluorobenzene-induced chronic itch.
    Title: Persistent Extracellular Signal-Regulated Kinase Activation by the Histamine H4 Receptor in Spinal Neurons Underlies Chronic Itch.
  9. Results suggest that TNF-alpha mRNA expression via histamine H4 receptors may contribute to the development of cisplatin-induced anorexia, and that histamine H4 receptor antagonists are potentially useful treatments.
    Title: Effects of a histamine H(4) receptor antagonist on cisplatin-induced anorexia in mice.
  10. colonic mast cells-derived histamine initiates granulocyte infiltration into the colonic mucosa through H4R
    Title: Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC130500

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histamine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histamine receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histamine H4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153087.2 → NP_694727.1  histamine H4 receptor

    See identical proteins and their annotated locations for NP_694727.1

    Status: VALIDATED

    Source sequence(s)
    AC131672
    Consensus CDS
    CCDS29069.1
    UniProtKB/Swiss-Prot
    Q91ZY2
    Related
    ENSMUSP00000041061.3, ENSMUST00000041676.3
    Conserved Domains (1) summary
    pfam00001
    Location:32 → 360
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    13140039..13156758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317874.1 → XP_017173363.1  histamine H4 receptor isoform X2

    UniProtKB/TrEMBL
    B2ZGH2
    Related
    ENSMUSP00000157130.2, ENSMUST00000234565.2
    Conserved Domains (2) summary
    cd14964
    Location:18 → 42
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:16 → 129
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006525817.2 → XP_006525880.1  histamine H4 receptor isoform X1

    See identical proteins and their annotated locations for XP_006525880.1

    UniProtKB/TrEMBL
    Q2M2N7
    Conserved Domains (2) summary
    cd14964
    Location:5 → 21
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 247
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZY2.1 GenPept UniProtKB/Swiss-Prot:Q91ZY2

Gene LinkOut

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