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Lclat1 lysocardiolipin acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 225010, updated on 19-Mar-2024

Summary

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Official Symbol
Lclat1provided by MGI
Official Full Name
lysocardiolipin acyltransferase 1provided by MGI
Primary source
MGI:MGI:2684937
See related
Ensembl:ENSMUSG00000054469 AllianceGenome:MGI:2684937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm91; Lycat; Agpat8; Alcat1; 1-AGPAT 8
Summary
Enables acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to act upstream of or within phospholipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including arterial system; gonad; heart; immune system; and respiratory system. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.0), large intestine adult (RPKM 5.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E1.3- E2; 17 44.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73414980..73550363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (73107985..73243368)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:73403131-73403314 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:73403592-73403802 Neighboring gene predicted gene, 30476 Neighboring gene STARR-seq mESC enhancer starr_43198 Neighboring gene predicted gene, 41616 Neighboring gene STARR-seq mESC enhancer starr_43199 Neighboring gene STARR-positive B cell enhancer ABC_E8695 Neighboring gene STARR-seq mESC enhancer starr_43201 Neighboring gene STARR-positive B cell enhancer ABC_E7555 Neighboring gene predicted gene, 25406 Neighboring gene UDP-glucuronate decarboxylase 1 pseudogene Neighboring gene RIKEN cDNA E330032C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E398 Neighboring gene STARR-positive B cell enhancer ABC_E10970 Neighboring gene STARR-positive B cell enhancer ABC_E7556 Neighboring gene calpain 13 Neighboring gene STARR-seq mESC enhancer starr_43202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Song C, et al. Aging Cell, 2019 Jun. PMID 30838774, Free PMC Article
  2. ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. Wang L, et al. Hepatology, 2015 Feb. PMID 25203315, Free PMC Article
  3. Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy. Liu X, et al. Mol Cell Biol, 2012 Nov. PMID 22949503, Free PMC Article
  4. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Li J, et al. Cell Metab, 2010 Aug 4. PMID 20674860, Free PMC Article
  5. Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems. Wang W, et al. Dev Dyn, 2010 Jun. PMID 20503378

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction.
    Title: Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction.
  2. Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation.
    Title: Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation.
  3. ALCAT1 expression is upregulated by MPTP and by alpha-synucleinopathy, a key hallmark of Parkinson's disease (PD), whereas ALCAT1 deficiency prevented alpha-synuclein oligomerization and S-129 phosphorylation, implicating a key role of ALCAT1 in the etiology of mouse models of PD.
    Title: Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.
  4. Lycat regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis.
    Title: Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.
  5. Alcat1 is destabilized in epithelia by lipopolysaccharide (LPS) impairing mitochondrial function.
    Title: LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.
  6. Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the alpha-subunit of trifunctional protein heterozygous knockout mice
    Title: Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the α-subunit of trifunctional protein heterozygous knockout mice.
  7. pathological cardiolipin remodeling by ALCAT1 linked to the pathogenesis of nonalcoholic fatty liver diseases
    Title: ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
  8. LYCAT expression was altered in peripheral blood mononuclear cells and outcome in pulmonary fibrosis.
    Title: The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
  9. findings implicate a key role of ALCAT1 as the missing link between oxidative stress and mitochondrial dysfunction in the etiology of age-related heart diseases
    Title: Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy.
  10. overexpression of ALCAT1 causes mitochondrial fragmentation through oxidative stress and depletion of mitofusin mitofusin 2 (MFN2) expression
    Title: Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin acyl-chain remodeling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysocardiolipin acyltransferase 1
Names
1-AGP acyltransferase 8
1-acylglycerol-3-phosphate O-acyltransferase 8
acyl-CoA:lysocardiolipin acyltransferase 1
NP_001074540.1
NP_001171438.1
NP_001171439.1
XP_036016461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081071.2 → NP_001074540.1  lysocardiolipin acyltransferase 1

    See identical proteins and their annotated locations for NP_001074540.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC112949, AI847050, BB868193, BC158076
    Consensus CDS
    CCDS37689.1
    UniProtKB/Swiss-Prot
    Q3UN02
    UniProtKB/TrEMBL
    A0A3B2WDB3, B0V2Q7
    Related
    ENSMUSP00000068690.7, ENSMUST00000067545.8
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 302
    Acyltransf_C; Acyltransferase C-terminus

  2. NM_001177967.1 → NP_001171438.1  lysocardiolipin acyltransferase 1

    See identical proteins and their annotated locations for NP_001171438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC112949, AI847050, BB868193, BC147499
    Consensus CDS
    CCDS37689.1
    UniProtKB/Swiss-Prot
    Q3UN02
    UniProtKB/TrEMBL
    A0A3B2WDB3, B0V2Q7
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 302
    Acyltransf_C; Acyltransferase C-terminus

  3. NM_001177968.1 → NP_001171439.1  lysocardiolipin acyltransferase 1

    See identical proteins and their annotated locations for NP_001171439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC112949, AI847050, BB868193, BC150884
    Consensus CDS
    CCDS37689.1
    UniProtKB/Swiss-Prot
    Q3UN02
    UniProtKB/TrEMBL
    A0A3B2WDB3, B0V2Q7
    Related
    ENSMUSP00000156922.2, ENSMUST00000232703.2
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 302
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    73414980..73550363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160568.1 → XP_036016461.1  lysocardiolipin acyltransferase 1 isoform X1

    Conserved Domains (2) summary
    cd07990
    Location:171 → 364
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:349 → 422
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UN02.2 GenPept UniProtKB/Swiss-Prot:Q3UN02

Gene LinkOut

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