U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dus3l dihydrouridine synthase 3 like [ Mus musculus (house mouse) ]

Gene ID: 224907, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Dus3lprovided by MGI
Official Full Name
dihydrouridine synthase 3 likeprovided by MGI
Primary source
MGI:MGI:2147092
See related
Ensembl:ENSMUSG00000007603 AllianceGenome:MGI:2147092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 54.5), ovary adult (RPKM 49.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 D; 17 29.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57069224..57077093)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56764751..56770093)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 4, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:56897018-56897127 Neighboring gene neurturin Neighboring gene STARR-positive B cell enhancer ABC_E5624 Neighboring gene proline rich 22 Neighboring gene regulatory factor X, 2 (influences HLA class II expression) Neighboring gene predicted gene, 41604

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC56820

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA dihydrouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-dihydrouridine47 synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
Names
mRNA-dihydrouridine synthase DUS3L
putative zinc finger protein MA23
NP_001347334.1
NP_659107.2
XP_036016453.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360405.1 → NP_001347334.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    CT010491
    UniProtKB/Swiss-Prot
    Q3TZQ1, Q7TT12, Q91XI1
    Conserved Domains (1) summary
    cd02801
    Location:293 → 488
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  2. NM_144858.2 → NP_659107.2  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1

    See identical proteins and their annotated locations for NP_659107.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA123957, BI133429, BM224665, BY295359, CK387816, CX201215, DV647483
    Consensus CDS
    CCDS28914.1
    UniProtKB/Swiss-Prot
    Q3TZQ1, Q7TT12, Q91XI1
    UniProtKB/TrEMBL
    A0A0R4IZY9
    Related
    ENSMUSP00000007747.9, ENSMUST00000007747.10
    Conserved Domains (2) summary
    COG0042
    Location:284 → 563
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:293 → 525
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57069224..57077093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160560.1 → XP_036016453.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

    UniProtKB/Swiss-Prot
    Q3TZQ1, Q7TT12, Q91XI1
    Conserved Domains (2) summary
    cd02801
    Location:293 → 584
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam18044
    Location:111 → 135
    zf-CCCH_4; CCCH-type zinc finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XI1.1 GenPept UniProtKB/Swiss-Prot:Q91XI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous