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Usp49 ubiquitin specific peptidase 49 [ Mus musculus (house mouse) ]

Gene ID: 224836, updated on 11-Apr-2024

Summary

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Official Symbol
Usp49provided by MGI
Official Full Name
ubiquitin specific peptidase 49provided by MGI
Primary source
MGI:MGI:2685391
See related
Ensembl:ENSMUSG00000090115 AllianceGenome:MGI:2685391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm545; C330046L10Rik
Summary
Predicted to enable cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA processing; chromatin organization; and proteolysis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.6), CNS E14 (RPKM 9.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 23.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47941615..47997664)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47630690..47686739)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene bystin-like Neighboring gene predicted gene 20517 Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Ye L, et al. PLoS Pathog, 2019 Apr. PMID 30943264, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Usp49 is associated with increased resistance to lethal HSV-1 infection.
    Title: USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Gm20517

Readthrough gene: Gm20517, Included gene: Med20

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2B deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 49
Names
deubiquitinating enzyme 49
ubiquitin thioesterase 49
ubiquitin thiolesterase 49
ubiquitin-specific-processing protease 49
NP_940813.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198421.2 → NP_940813.1  ubiquitin carboxyl-terminal hydrolase 49

    See identical proteins and their annotated locations for NP_940813.1

    Status: VALIDATED

    Source sequence(s)
    AC139214, BC060712
    Consensus CDS
    CCDS28852.1
    UniProtKB/Swiss-Prot
    Q6P9L4
    Related
    ENSMUSP00000024779.9, ENSMUST00000024779.15
    Conserved Domains (3) summary
    cl02553
    Location:251 → 652
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:249 → 651
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47941615..47997664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9L4.1 GenPept UniProtKB/Swiss-Prot:Q6P9L4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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