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Ubr2 ubiquitin protein ligase E3 component n-recognin 2 [ Mus musculus (house mouse) ]

Gene ID: 224826, updated on 21-Apr-2024

Summary

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Official Symbol
Ubr2provided by MGI
Official Full Name
ubiquitin protein ligase E3 component n-recognin 2provided by MGI
Primary source
MGI:MGI:1861099
See related
Ensembl:ENSMUSG00000023977 AllianceGenome:MGI:1861099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0349; 9930021A08Rik; E130209G04Rik
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including histone H2A ubiquitination; male gamete generation; and negative regulation of transposition. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Colocalizes with chromatin. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 12.1), thymus adult (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.91 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47239217..47321812, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46928291..47010886, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene tubulin-specific chaperone C Neighboring gene peripherin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3205 Neighboring gene STARR-positive B cell enhancer ABC_E4216 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene ribosomal protein L29 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway. Mao J, et al. Stem Cells, 2017 Nov. PMID 28895255
  2. Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair. Ouyang Y, et al. Mutat Res, 2006 Apr 11. PMID 16488448
  3. UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting. Gao S, et al. Proc Natl Acad Sci U S A, 2022 Oct 25. PMID 36252004, Free PMC Article
  4. Loss of RAD6B induces degeneration of the cochlea in mice. Ma Y, et al. Biochem Biophys Res Commun, 2020 Oct 20. PMID 32868078
  5. The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids. Mulugeta Achame E, et al. BMC Genomics, 2010 Jun 10. PMID 20537150, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting.
    Title: UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting.
  2. Taken together, our findings indicated that p53(-/-) mBMMSC exosomes could deliver UBR2 to target cells and promote gastric cancer growth and metastasis by regulating Wnt/beta-catenin pathway.
    Title: UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway.
  3. These data suggest that Tex19.1 and Ubr2 are required for mouse spermatocytes to accumulate sufficient Spo11-dependent recombination to ensure that the homology search is consistently successful, and reveal a hitherto unknown genetic pathway promoting meiotic recombination in mammals.
    Title: Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes.
  4. Results suggest that UBR2 up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
    Title: Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2.
  5. Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.
    Title: The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.
  6. insufficiency in UBR2-dependent histone ubiquitination triggers a pachytene checkpoint system, providing a new insight into chromatin remodeling and gene expression regulation
    Title: UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.
  7. UBR2 ubiquitin ligase and the N-end rule pathway are required for male meiosis and spermatogenesis and for an essential aspect of female embryonic development.
    Title: Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.
  8. mouse fibroblast cells derived from Ubr2 deficient embryos display genome instability.
    Title: Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair.
  9. UBR1-/-UBR2-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.
    Title: Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0349, MGC36320

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-leucine binding ISO
Inferred from Sequence Orthology
more info
  
enables histone ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase UBR2
Names
N-recognin-2
RING-type E3 ubiquitin transferase UBR2
ubiquitin ligase E3 alpha-II
ubiquitin-protein ligase E3-alpha-2
ubiquitin-protein ligase E3-alpha-II
NP_001170845.1
NP_666190.2
XP_006524208.1
XP_030105595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177374.2 → NP_001170845.1  E3 ubiquitin-protein ligase UBR2 isoform 2

    See identical proteins and their annotated locations for NP_001170845.1

    Status: VALIDATED

    Source sequence(s)
    AC165289, AC170807
    Consensus CDS
    CCDS50127.1
    UniProtKB/TrEMBL
    Q3UHE0, Q3UPU3
    Related
    ENSMUSP00000108961.3, ENSMUST00000113335.4
    Conserved Domains (2) summary
    pfam02207
    Location:99 → 166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:222 → 300
    ClpS; ATP-dependent Clp protease adaptor protein ClpS

  2. NM_146078.4 → NP_666190.2  E3 ubiquitin-protein ligase UBR2 isoform 1

    See identical proteins and their annotated locations for NP_666190.2

    Status: VALIDATED

    Source sequence(s)
    AC165289, AC170807
    Consensus CDS
    CCDS28845.1
    UniProtKB/Swiss-Prot
    Q6DIB9, Q6WKZ8, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130
    UniProtKB/TrEMBL
    Q3UHE0
    Related
    ENSMUSP00000108963.3, ENSMUST00000113337.10
    Conserved Domains (2) summary
    pfam02207
    Location:99 → 166
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam02617
    Location:222 → 300
    ClpS; ATP-dependent Clp protease adaptor protein ClpS

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47239217..47321812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524145.3 → XP_006524208.1  E3 ubiquitin-protein ligase UBR2 isoform X2

    Conserved Domains (2) summary
    cd00162
    Location:422 → 527
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:421 → 536
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_030249735.2 → XP_030105595.1  E3 ubiquitin-protein ligase UBR2 isoform X1

    Conserved Domains (2) summary
    cd00162
    Location:679 → 784
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:678 → 793
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_001782069.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WKZ8.2 GenPept UniProtKB/Swiss-Prot:Q6WKZ8

Gene LinkOut

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