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Abcc10 ATP-binding cassette, sub-family C member 10 [ Mus musculus (house mouse) ]

Gene ID: 224814, updated on 11-Apr-2024

Summary

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Official Symbol
Abcc10provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 10provided by MGI
Primary source
MGI:MGI:2386976
See related
Ensembl:ENSMUSG00000032842 AllianceGenome:MGI:2386976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrp7; mFLJ00002
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum adult (RPKM 18.2), colon adult (RPKM 18.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.9 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46614146..46638954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46303220..46328031, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tight junction associated protein 1 Neighboring gene predicted gene, 41588 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene STARR-positive B cell enhancer ABC_E1943 Neighboring gene cDNA sequence BC040756 Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice. Otaibi AA, et al. Int J Mol Sci, 2022 Nov 10. PMID 36430292, Free PMC Article
  2. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Hopper-Borge EA, et al. Cancer Res, 2011 May 15. PMID 21576088, Free PMC Article
  3. cDNA cloning and genomic organization of the murine MRP7, a new ATP-binding cassette transporter. Kao HH, et al. Gene, 2002 Mar 20. PMID 11943485
  4. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). Yang QS, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997112
  5. Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines. Naramoto H, et al. Int J Oncol, 2007 Feb. PMID 17203221

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice.
    Title: ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice.
  2. Abcc10 is dispensable for health and viability and it is an endogenous resistance factor for taxanes, other natural product agents, and nucleoside analogues
    Title: Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice.
  3. MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma
    Title: Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type glutathione S-conjugate transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 10
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
multidrug resistance-associated protein 7
NP_001334325.1
NP_660122.1
NP_733780.1
XP_017172930.1
XP_017172931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347396.1 → NP_001334325.1  ATP-binding cassette sub-family C member 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK133240, BC060644, BP757737, CT009572
    Consensus CDS
    CCDS84315.1
    UniProtKB/TrEMBL
    B9EKB9
    Related
    ENSMUSP00000038041.8, ENSMUST00000047970.14

  2. NM_145140.2 → NP_660122.1  ATP-binding cassette sub-family C member 10 isoform mrp7A

    See identical proteins and their annotated locations for NP_660122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (mrp7A) encodes the shortest isoform (mrp7A).
    Source sequence(s)
    AF406642, CO042416
    Consensus CDS
    CCDS28825.1
    UniProtKB/TrEMBL
    B9EKB9
    Related
    ENSMUSP00000092895.4, ENSMUST00000095261.10
    Conserved Domains (4) summary
    cd03244
    Location:1212 → 1431
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:558 → 761
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:179 → 1437
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:921 → 1155
    ABC_membrane; ABC transporter transmembrane region

  3. NM_170680.2 → NP_733780.1  ATP-binding cassette sub-family C member 10 isoform mrp7B

    See identical proteins and their annotated locations for NP_733780.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (mrp7B) contains a distinct 5' UTR and 5' coding region, compared to variant mrp7A. This results in a distinct N-terminus and longer isoform (mrp7B) but maintains the same reading frame as isoform mrp7A.
    Source sequence(s)
    AC151275, AF417121, CO042416
    Consensus CDS
    CCDS50124.1
    UniProtKB/Swiss-Prot
    Q3TCQ0, Q3V0D1, Q8R4P9, Q8R4S1
    UniProtKB/TrEMBL
    B9EKB9
    Related
    ENSMUSP00000131843.2, ENSMUST00000167360.8
    Conserved Domains (4) summary
    cd03244
    Location:1253 → 1472
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:599 → 802
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:220 → 1478
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:962 → 1196
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. NR_182268.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CT009572

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46614146..46638954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317442.2 → XP_017172931.1  ATP-binding cassette sub-family C member 10 isoform X2

    Conserved Domains (1) summary
    TIGR00957
    Location:2 → 851
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  2. XM_017317441.3 → XP_017172930.1  ATP-binding cassette sub-family C member 10 isoform X1

    Conserved Domains (4) summary
    TIGR00957
    Location:203 → 911
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd07346
    Location:887 → 910
    ABC_6TM_exporters; TM helix 1 [structural motif]
    cd18598
    Location:289 → 572
    ABC_6TM_MRP7_D1_like; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 7, and similar proteins
    cl38913
    Location:887 → 994
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters

RNA

  1. XR_004939517.1 RNA Sequence

  2. XR_385318.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4P9.1 GenPept UniProtKB/Swiss-Prot:Q8R4P9

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