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Tmem63b transmembrane protein 63b [ Mus musculus (house mouse) ]

Gene ID: 224807, updated on 10-Mar-2024

Summary

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Official Symbol
Tmem63bprovided by MGI
Official Full Name
transmembrane protein 63bprovided by MGI
Primary source
MGI:MGI:2387609
See related
Ensembl:ENSMUSG00000036026 AllianceGenome:MGI:2387609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calcium activated cation channel activity; mechanosensitive ion channel activity; and osmolarity-sensing cation channel activity. Predicted to act upstream of or within ion transport. Located in plasma membrane. Is expressed in jaw bone; nervous system; and sensory organ. Orthologous to human TMEM63B (transmembrane protein 63B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 53.9), whole brain E14.5 (RPKM 46.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.59 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45971102..45997212, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45660172..45686343, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52283 Neighboring gene STARR-positive B cell enhancer ABC_E9955 Neighboring gene predicted gene, 25008 Neighboring gene STARR-positive B cell enhancer ABC_E10956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45775877-45776144 Neighboring gene calpain 11 Neighboring gene STARR-positive B cell enhancer ABC_E7534 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene predicted gene, 35456 Neighboring gene RIKEN cDNA 1600014C23 gene Neighboring gene cDNA sequence BE949265

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Cation Channel TMEM63B Is an Osmosensor Required for Hearing. Du H, et al. Cell Rep, 2020 May 5. PMID 32375046
  2. Overexpression of Osmosensitive Ca(2+)-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells. Marques MC, et al. Biochemistry, 2019 Jul 2. PMID 31243992
  3. Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Zhao X, et al. Cell Biochem Funct, 2016 Jun. PMID 27045885
  4. OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels. Murthy SE, et al. Elife, 2018 Nov 1. PMID 30382938, Free PMC Article
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion.
    Title: Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion.
  2. TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception.
    Title: Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables osmolarity-sensing monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CSC1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413622.1 → NP_001400551.1  CSC1-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165259
    UniProtKB/Swiss-Prot
    Q3TWI9, Q6PCL2, Q6PGA4, Q8C1V5, Q8R0W7

  2. NM_001413623.1 → NP_001400552.1  CSC1-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165259
    UniProtKB/Swiss-Prot
    Q3TWI9, Q6PCL2, Q6PGA4, Q8C1V5, Q8R0W7

  3. NM_001413624.1 → NP_001400553.1  CSC1-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165259

  4. NM_001413625.1 → NP_001400554.1  CSC1-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165259

  5. NM_001413626.1 → NP_001400555.1  CSC1-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165259

  6. NM_198167.4 → NP_937810.2  CSC1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_937810.2

    Status: VALIDATED

    Source sequence(s)
    AC165259
    Consensus CDS
    CCDS28814.1
    UniProtKB/Swiss-Prot
    Q3TWI9, Q6PCL2, Q6PGA4, Q8C1V5, Q8R0W7
    Related
    ENSMUSP00000109151.3, ENSMUST00000113523.9
    Conserved Domains (3) summary
    pfam02714
    Location:433 → 704
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52 → 221
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:240 → 422
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45971102..45997212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249734.2 → XP_030105594.1  CSC1-like protein 2 isoform X2

    Conserved Domains (3) summary
    pfam02714
    Location:420 → 691
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam13967
    Location:52 → 208
    RSN1_TM; Late exocytosis, associated with Golgi transport
    pfam14703
    Location:227 → 409
    PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

RNA

  1. XR_001782067.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TWI9.1 GenPept UniProtKB/Swiss-Prot:Q3TWI9

Gene LinkOut

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