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Zfp81 zinc finger protein 81 [ Mus musculus (house mouse) ]

Gene ID: 224694, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp81provided by MGI
Official Full Name
zinc finger protein 81provided by MGI
Primary source
MGI:MGI:1890752
See related
Ensembl:ENSMUSG00000003929 AllianceGenome:MGI:1890752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp78; KRAB13; Hszfp36; C330034P10Rik; D330034E10Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.8), CNS E14 (RPKM 4.5) and 18 other tissues See more
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Genomic context

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See Zfp81 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33548316..33577874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33329342..33358896, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily H member 28 Neighboring gene STARR-positive B cell enhancer mm9_chr17:33426236-33426537 Neighboring gene zinc finger protein 955B Neighboring gene zinc finger protein 422, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:33495732-33496033 Neighboring gene zinc finger protein 101 Neighboring gene actin-like 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  3. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
  4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 81
Names
ZFP-36 zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207541.1 → NP_997424.1  zinc finger protein 81

    Status: VALIDATED

    Source sequence(s)
    AK135853, BB143786
    Consensus CDS
    CCDS37564.1
    UniProtKB/TrEMBL
    B8JJZ7
    Related
    ENSMUSP00000050728.9, ENSMUST00000054072.9
    Conserved Domains (5) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:277 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:488 → 513
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33548316..33577874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249699.2 → XP_030105559.1  zinc finger protein 81 isoform X2

    Related
    ENSMUSP00000157222.2, ENSMUST00000234016.2
    Conserved Domains (3) summary
    COG5048
    Location:213 → 373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:424 → 449
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030249697.2 → XP_030105557.1  zinc finger protein 81 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:245 → 405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456 → 481
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030249698.1 → XP_030105558.1  zinc finger protein 81 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:245 → 405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456 → 481
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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