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Slc37a1 solute carrier family 37 (glycerol-3-phosphate transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 224674, updated on 11-Apr-2024

Summary

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Official Symbol
Slc37a1provided by MGI
Official Full Name
solute carrier family 37 (glycerol-3-phosphate transporter), member 1provided by MGI
Primary source
MGI:MGI:2446181
See related
Ensembl:ENSMUSG00000024036 AllianceGenome:MGI:2446181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G3PP
Summary
Predicted to enable glucose 6-phosphate:inorganic phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human SLC37A1 (solute carrier family 37 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 42.5), large intestine adult (RPKM 20.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 16.03 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31495722..31569683)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31295135..31350709)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31341993-31342102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31344766-31345042 Neighboring gene STARR-positive B cell enhancer ABC_E3196 Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene STARR-positive B cell enhancer ABC_E10945 Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene phosphodiesterase 9A Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31649222-31649405 Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene WD repeat domain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28167

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose-6-phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-6-phosphate exchanger SLC37A1
Names
glycerol-3-phosphate transporter
solute carrier family 37 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242427.1 → NP_001229356.1  glucose-6-phosphate exchanger SLC37A1

    See identical proteins and their annotated locations for NP_001229356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK153706, CO039406, CX235981
    Consensus CDS
    CCDS37548.1
    UniProtKB/Swiss-Prot
    Q3UPC2, Q8R070
    UniProtKB/TrEMBL
    Q3TQ11
    Related
    ENSMUSP00000128223.2, ENSMUST00000165149.3
    Conserved Domains (1) summary
    cd17344
    Location:21 → 514
    MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

  2. NM_153062.2 → NP_694702.1  glucose-6-phosphate exchanger SLC37A1

    See identical proteins and their annotated locations for NP_694702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC154652
    Consensus CDS
    CCDS37548.1
    UniProtKB/Swiss-Prot
    Q3UPC2, Q8R070
    UniProtKB/TrEMBL
    Q3TQ11
    Related
    ENSMUSP00000126111.2, ENSMUST00000171233.9
    Conserved Domains (1) summary
    cd17344
    Location:21 → 514
    MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31495722..31569683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160526.1 → XP_036016419.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UPC2, Q8R070
    UniProtKB/TrEMBL
    Q3TQ11
    Conserved Domains (1) summary
    cd17344
    Location:21 → 514
    MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

  2. XM_006524097.5 → XP_006524160.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    See identical proteins and their annotated locations for XP_006524160.1

    UniProtKB/Swiss-Prot
    Q3UPC2, Q8R070
    UniProtKB/TrEMBL
    Q3TQ11
    Conserved Domains (1) summary
    cd17344
    Location:21 → 514
    MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

  3. XM_011246396.4 → XP_011244698.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    See identical proteins and their annotated locations for XP_011244698.1

    UniProtKB/Swiss-Prot
    Q3UPC2, Q8R070
    UniProtKB/TrEMBL
    Q3TQ11
    Related
    ENSMUSP00000157617.2, ENSMUST00000236251.2
    Conserved Domains (1) summary
    cd17344
    Location:21 → 514
    MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

  4. XM_006524099.5 → XP_006524162.1  glucose-6-phosphate exchanger SLC37A1 isoform X2

    UniProtKB/TrEMBL
    Q8K0Y8
    Conserved Domains (1) summary
    cl28910
    Location:1 → 322
    MFS; Major Facilitator Superfamily

  5. XM_017317410.3 → XP_017172899.1  glucose-6-phosphate exchanger SLC37A1 isoform X3

    UniProtKB/TrEMBL
    Q8K0Y8
    Conserved Domains (1) summary
    cl28910
    Location:88 → 277
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R070.1 GenPept UniProtKB/Swiss-Prot:Q8R070

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