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Slc26a8 solute carrier family 26, member 8 [ Mus musculus (house mouse) ]

Gene ID: 224661, updated on 11-Apr-2024

Summary

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Official Symbol
Slc26a8provided by MGI
Official Full Name
solute carrier family 26, member 8provided by MGI
Primary source
MGI:MGI:2385046
See related
Ensembl:ENSMUSG00000036196 AllianceGenome:MGI:2385046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable anion transmembrane transporter activity. Predicted to be involved in chloride transport; oxalate transport; and sulfate transport. Predicted to act upstream of or within several processes, including ion transport; meiotic cell cycle; and spermatogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in spermatogenic failure 3. Orthologous to human SLC26A8 (solute carrier family 26 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 35.0) and cortex adult (RPKM 1.2) See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 14.82 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28856757..28910242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28637779..28691273, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lipoma HMGIC fusion partner-like 5 Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28828272-28828381 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene G protein subunit gamma 5C Neighboring gene mitogen-activated protein kinase 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The heterozygous mutations of SLC26A8 are not the main actors for male infertility. Liu M, et al. Hum Mutat, 2022 May. PMID 35181959
  2. The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse. Touré A, et al. Hum Mol Genet, 2007 Aug 1. PMID 17517695
  3. The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation. Rode B, et al. Hum Mol Genet, 2012 Mar 15. PMID 22121115
  4. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Longo-Guess CM, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905332, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The heterozygous mutations of SLC26A8 are not the main actors for male infertility.
    Title: The heterozygous mutations of SLC26A8 are not the main actors for male infertility.
  2. Tat1 (Slc26A8) is a critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
    Title: The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38861

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate:chloride antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in oxalate transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testis anion transporter 1
Names
anion exchange transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290320.2 → NP_001277249.1  testis anion transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001277249.1

    Status: VALIDATED

    Source sequence(s)
    AC170998
    Consensus CDS
    CCDS70779.1
    UniProtKB/Swiss-Prot
    Q8R0C3
    UniProtKB/TrEMBL
    A0A3B2WCZ8
    Related
    ENSMUSP00000110412.2, ENSMUST00000114764.8
    Conserved Domains (2) summary
    cd07042
    Location:719 → 778
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:76 → 582
    sulP; high affinity sulphate transporter 1

  2. NM_001410514.1 → NP_001397443.1  testis anion transporter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC170998

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28856757..28910242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249692.2 → XP_030105552.1  testis anion transporter 1 isoform X6

    UniProtKB/TrEMBL
    A0A3B2WCZ8
    Related
    ENSMUSP00000156769.2, ENSMUST00000233249.2
    Conserved Domains (2) summary
    cd07042
    Location:664 → 723
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:76 → 527
    sulP; high affinity sulphate transporter 1

  2. XM_036160519.1 → XP_036016412.1  testis anion transporter 1 isoform X3

    UniProtKB/TrEMBL
    A0A3B2WCZ8
    Conserved Domains (2) summary
    cd07042
    Location:724 → 783
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:81 → 587
    sulP; high affinity sulphate transporter 1

  3. XM_011246387.4 → XP_011244689.1  testis anion transporter 1 isoform X4

    UniProtKB/TrEMBL
    A0A3B2WCZ8
    Conserved Domains (2) summary
    cd07042
    Location:692 → 751
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:104 → 555
    sulP; high affinity sulphate transporter 1

  4. XM_011246388.4 → XP_011244690.1  testis anion transporter 1 isoform X5

    Conserved Domains (1) summary
    TIGR00815
    Location:104 → 610
    sulP; high affinity sulphate transporter 1

  5. XM_011246385.4 → XP_011244687.1  testis anion transporter 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B2WCZ8
    Conserved Domains (2) summary
    TIGR00815
    Location:104 → 610
    sulP; high affinity sulphate transporter 1
    cl00604
    Location:747 → 798
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

  6. XM_011246384.4 → XP_011244686.1  testis anion transporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A3B2WCZ8
    Conserved Domains (2) summary
    cd07042
    Location:747 → 806
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:104 → 610
    sulP; high affinity sulphate transporter 1

  7. XM_036160521.1 → XP_036016414.1  testis anion transporter 1 isoform X9

    Conserved Domains (2) summary
    cd07042
    Location:283 → 342
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    COG0659
    Location:2 → 141
    SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]

  8. XM_011246394.1 → XP_011244696.1  testis anion transporter 1 isoform X11

    Conserved Domains (2) summary
    cd07042
    Location:226 → 285
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:27 → 89
    sulP; high affinity sulphate transporter 1

  9. XM_011246389.4 → XP_011244691.1  testis anion transporter 1 isoform X7

    Conserved Domains (1) summary
    TIGR00815
    Location:104 → 610
    sulP; high affinity sulphate transporter 1

  10. XM_011246390.4 → XP_011244692.1  testis anion transporter 1 isoform X8

    Conserved Domains (1) summary
    TIGR00815
    Location:104 → 610
    sulP; high affinity sulphate transporter 1

  11. XM_011246391.3 → XP_011244693.1  testis anion transporter 1 isoform X10

    Conserved Domains (1) summary
    pfam00916
    Location:118 → 517
    Sulfate_transp; Sulfate permease family

RNA

  1. XR_001782064.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_146076.1: Suppressed sequence

    Description
    NM_146076.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript, and the protein is short compared to homologs.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0C3.2 GenPept UniProtKB/Swiss-Prot:Q8R0C3

Gene LinkOut

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