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Zfp523 zinc finger protein 523 [ Mus musculus (house mouse) ]

Gene ID: 224656, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp523provided by MGI
Official Full Name
zinc finger protein 523provided by MGI
Primary source
MGI:MGI:2687278
See related
Ensembl:ENSMUSG00000024220 AllianceGenome:MGI:2687278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf76; 2810027J07
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; limb mesenchyme; oocyte; and urinary system. Orthologous to human ZNF76 (zinc finger protein 76). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 32.4), adrenal adult (RPKM 23.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 14.63 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28396136..28424860)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28177196..28205886)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42185 Neighboring gene STARR-positive B cell enhancer ABC_E4199 Neighboring gene t-complex protein 11 Neighboring gene VISTA enhancer mm1525 Neighboring gene signal peptide, CUB domain, EGF-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28344631-28344740 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28348857-28349040 Neighboring gene STARR-seq mESC enhancer starr_42195 Neighboring gene STARR-positive B cell enhancer ABC_E7505 Neighboring gene STARR-positive B cell enhancer ABC_E10940 Neighboring gene STARR-seq mESC enhancer starr_42199 Neighboring gene STARR-positive B cell enhancer ABC_E4200 Neighboring gene differentially expressed in FDCP 6 Neighboring gene peroxisome proliferator activator receptor delta Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28393851-28394218 Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28407203-28407312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP. Prigge JR, et al. J Biol Chem, 2006 May 5. PMID 16522640, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of gene regulatory interplay between TBP, PIAS1, PIAS3, PIASx, PIASy, ZFP523, and transcription factors
    Title: Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC66570, MGC79196

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357995.2 → NP_001344924.1  zinc finger protein 76 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126937
    Consensus CDS
    CCDS28573.1
    UniProtKB/Swiss-Prot
    Q6P9T2, Q8BMU0
    UniProtKB/TrEMBL
    A0A3B2W3I6
    Related
    ENSMUSP00000073226.3, ENSMUST00000073534.10
    Conserved Domains (2) summary
    COG5048
    Location:179 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001413647.1 → NP_001400576.1  zinc finger protein 76 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126937
    UniProtKB/Swiss-Prot
    Q6P9T2, Q8BMU0
    Related
    ENSMUSP00000156638.2, ENSMUST00000233613.2

  3. NM_001413648.1 → NP_001400577.1  zinc finger protein 76 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126937

  4. NM_001413649.1 → NP_001400578.1  zinc finger protein 76 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126937

  5. NM_172617.4 → NP_766205.1  zinc finger protein 76 isoform 1

    See identical proteins and their annotated locations for NP_766205.1

    Status: VALIDATED

    Source sequence(s)
    AC126937
    Consensus CDS
    CCDS28573.1
    UniProtKB/Swiss-Prot
    Q6P9T2, Q8BMU0
    UniProtKB/TrEMBL
    A0A3B2W3I6
    Related
    ENSMUSP00000002318.2, ENSMUST00000002318.8
    Conserved Domains (2) summary
    COG5048
    Location:179 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_182184.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126937
    Related
    ENSMUST00000233841.2

  2. NR_182185.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126937

  3. NR_182186.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126937

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28396136..28424860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249689.2 → XP_030105549.1  zinc finger protein 76 isoform X2

    Conserved Domains (2) summary
    COG5189
    Location:95 → 152
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:101 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030249690.1 → XP_030105550.1  zinc finger protein 76 isoform X2

    Related
    ENSMUST00000145313.8
    Conserved Domains (2) summary
    COG5189
    Location:95 → 152
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:101 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMU0.1 GenPept UniProtKB/Swiss-Prot:Q8BMU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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