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Zdhhc14 zinc finger, DHHC domain containing 14 [ Mus musculus (house mouse) ]

Gene ID: 224454, updated on 11-Apr-2024

Summary

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Official Symbol
Zdhhc14provided by MGI
Official Full Name
zinc finger, DHHC domain containing 14provided by MGI
Primary source
MGI:MGI:2653229
See related
Ensembl:ENSMUSG00000034265 AllianceGenome:MGI:2653229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
New1cp; B530001K09Rik
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in oocyte. Orthologous to human ZDHHC14 (zinc finger DHHC-type palmitoyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 3.4), thymus adult (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A1; 17 3.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (5542220..5810517)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (5492562..5753891)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr17:5429429-5429729 Neighboring gene transmembrane protein 242 Neighboring gene predicted gene 29050 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:5440198-5440381 Neighboring gene lactate dehydrogenase A-like 6B Neighboring gene STARR-positive B cell enhancer ABC_E3179 Neighboring gene non-SMC condensin II complex, subunit H2 pseudogene Neighboring gene predicted gene, 52310 Neighboring gene predicted gene, 52305 Neighboring gene STARR-seq mESC enhancer starr_41701 Neighboring gene predicted gene, 53971 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:5700808-5701009 Neighboring gene STARR-positive B cell enhancer ABC_E11626 Neighboring gene predicted gene, 41519 Neighboring gene RIKEN cDNA 3300005D01 gene Neighboring gene STARR-positive B cell enhancer ABC_E7485 Neighboring gene STARR-positive B cell enhancer ABC_E10931

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Sanders SS, et al. Elife, 2020 Nov 13. PMID 33185190, Free PMC Article
  2. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
  3. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Jung H, et al. Nat Neurosci, 2018 Sep. PMID 30104731
  4. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
    Title: The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29194

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC14
Names
DHHC domain-containing cysteine-rich protein 14
DHHC-14
NEW1 domain containing protein
probable palmitoyltransferase ZDHHC14
zinc finger DHHC domain-containing protein 14
NP_666185.3
XP_006523277.1
XP_006523278.1
XP_006523279.1
XP_011244479.1
XP_017172893.1
XP_017172894.1
XP_017172896.1
XP_036016400.1
XP_036016401.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146073.3 → NP_666185.3  palmitoyltransferase ZDHHC14

    See identical proteins and their annotated locations for NP_666185.3

    Status: VALIDATED

    Source sequence(s)
    AK036699, AK041496, AK041648, AK046719, AK080845
    Consensus CDS
    CCDS37422.1
    UniProtKB/Swiss-Prot
    Q8BNR2, Q8BQQ1, Q8CFN0
    Related
    ENSMUSP00000086589.5, ENSMUST00000089185.6
    Conserved Domains (1) summary
    pfam01529
    Location:164 → 289
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    5542220..5810517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160508.1 → XP_036016401.1  palmitoyltransferase ZDHHC14 isoform X6

    Conserved Domains (1) summary
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  2. XM_006523216.5 → XP_006523279.1  palmitoyltransferase ZDHHC14 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  3. XM_036160507.1 → XP_036016400.1  palmitoyltransferase ZDHHC14 isoform X5

    Conserved Domains (1) summary
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  4. XM_006523214.4 → XP_006523277.1  palmitoyltransferase ZDHHC14 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:314 → 471
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  5. XM_006523215.4 → XP_006523278.1  palmitoyltransferase ZDHHC14 isoform X2

    Conserved Domains (1) summary
    cl19890
    Location:164 → 241
    DHHC; DHHC palmitoyltransferase

  6. XM_017317404.3 → XP_017172893.1  palmitoyltransferase ZDHHC14 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  7. XM_011246177.4 → XP_011244479.1  palmitoyltransferase ZDHHC14 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  8. XM_017317405.2 → XP_017172894.1  palmitoyltransferase ZDHHC14 isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:103 → 275
    PHA03247; large tegument protein UL36; Provisional
    cl19890
    Location:1 → 76
    DHHC; DHHC palmitoyltransferase

  9. XM_017317407.3 → XP_017172896.1  palmitoyltransferase ZDHHC14 isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:103 → 275
    PHA03247; large tegument protein UL36; Provisional
    cl19890
    Location:1 → 76
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQQ1.1 GenPept UniProtKB/Swiss-Prot:Q8BQQ1

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