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Dctn6 dynactin 6 [ Mus musculus (house mouse) ]

Gene ID: 22428, updated on 5-Mar-2024

Summary

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Official Symbol
Dctn6provided by MGI
Official Full Name
dynactin 6provided by MGI
Primary source
MGI:MGI:1343154
See related
Ensembl:ENSMUSG00000031516 AllianceGenome:MGI:1343154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p27; WS-3
Summary
Enables dynein complex binding activity. Acts upstream of or within mitotic spindle organization. Part of dynactin complex. Is expressed in embryo; extraembryonic component; oocyte; primitive endoderm; and yolk sac. Orthologous to human DCTN6 (dynactin subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 26.7), CNS E14 (RPKM 22.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dctn6 in Genome Data Viewer
Location:
8 A4; 8 20.9 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34557574..34575866, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (34090420..34108712, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39157 Neighboring gene predicted gene, 57792 Neighboring gene predicted gene, 40486 Neighboring gene predicted gene, 40487 Neighboring gene predicted gene 9951 Neighboring gene STARR-seq mESC enhancer starr_21158 Neighboring gene STARR-positive B cell enhancer ABC_E4998 Neighboring gene ERH mRNA splicing and mitosis factor retrotransposed, pseudogene Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene predicted gene, 39158

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains. Sharoar MG, et al. Neurobiol Aging, 2021 Nov. PMID 34371284, Free PMC Article
  2. Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. Murdock DG, et al. J Biol Chem, 1999 May 14. PMID 10318868
  3. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. Yeh TY, et al. EMBO J, 2013 Apr 3. PMID 23455152, Free PMC Article
  4. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. Eckley DM, et al. J Cell Biol, 1999 Oct 18. PMID 10525537, Free PMC Article
  5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.
    Title: Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.
  2. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
    Title: Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrion organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic spindle organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
dynactin subunit 6
Names
RGD containing protein
dynactin subunit p27
p27 dynactin subunit
protein WS-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293757.1 → NP_001280686.1  dynactin subunit 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK003618, BU756370, CA573939, DV062065
    Consensus CDS
    CCDS80870.1
    UniProtKB/TrEMBL
    D3Z4E5
    Related
    ENSMUSP00000113716.2, ENSMUST00000117243.8
    Conserved Domains (1) summary
    cd04646
    Location:36 → 184
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  2. NM_001293758.1 → NP_001280687.1  dynactin subunit 6 isoform 3

    See identical proteins and their annotated locations for NP_001280687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and has an alternate first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK003618, BU756370, CA579919, DV042569
    Consensus CDS
    CCDS80871.1
    UniProtKB/TrEMBL
    D3Z6H3
    Related
    ENSMUSP00000113280.2, ENSMUST00000118811.8
    Conserved Domains (1) summary
    cd04646
    Location:5 → 174
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  3. NM_001293759.1 → NP_001280688.1  dynactin subunit 6 isoform 4

    See identical proteins and their annotated locations for NP_001280688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK003618, BU756370, CA573939, CV560309
    UniProtKB/Swiss-Prot
    Q9WUB4
    Conserved Domains (1) summary
    cd04646
    Location:1 → 98
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  4. NM_011722.4 → NP_035852.1  dynactin subunit 6 isoform 2

    See identical proteins and their annotated locations for NP_035852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK003618, BU756370, CA573939
    Consensus CDS
    CCDS22238.1
    UniProtKB/Swiss-Prot
    Q8C2M9, Q9QZB8, Q9WUB4
    Related
    ENSMUSP00000033913.5, ENSMUST00000033913.11
    Conserved Domains (1) summary
    cd04646
    Location:10 → 179
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34557574..34575866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509094.3 → XP_006509157.1  dynactin subunit 6 isoform X1

    Conserved Domains (1) summary
    cd04646
    Location:10 → 197
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  2. XM_030243416.2 → XP_030099276.1  dynactin subunit 6 isoform X3

    Conserved Domains (1) summary
    cd04646
    Location:18 → 166
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  3. XM_036153882.1 → XP_036009775.1  dynactin subunit 6 isoform X4

    Conserved Domains (1) summary
    cd04646
    Location:1 → 98
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  4. XM_036153881.1 → XP_036009774.1  dynactin subunit 6 isoform X2

    Conserved Domains (1) summary
    cd04646
    Location:5 → 192
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

  5. XM_030243417.2 → XP_030099277.1  dynactin subunit 6 isoform X4

    Conserved Domains (1) summary
    cd04646
    Location:1 → 98
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUB4.1 GenPept UniProtKB/Swiss-Prot:Q9WUB4

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