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Impg2 interphotoreceptor matrix proteoglycan 2 [ Mus musculus (house mouse) ]

Gene ID: 224224, updated on 16-Apr-2024

Summary

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Official Symbol
Impg2provided by MGI
Official Full Name
interphotoreceptor matrix proteoglycan 2provided by MGI
Primary source
MGI:MGI:3044955
See related
Ensembl:ENSMUSG00000035270 AllianceGenome:MGI:3044955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsbp; IPM200; PG10.2; Spacrcan
Summary
Enables heparin binding activity and hyaluronic acid binding activity. Acts upstream of or within extracellular matrix organization; protein localization; and retina morphogenesis in camera-type eye. Located in interphotoreceptor matrix. Is expressed in embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Used to study retinitis pigmentosa 56 and vitelliform macular dystrophy. Human ortholog(s) of this gene implicated in retinitis pigmentosa 56 and vitelliform macular dystrophy. Orthologous to human IMPG2 (interphotoreceptor matrix proteoglycan 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Impg2 in Genome Data Viewer
Location:
16 C1.1; 16 33.91 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56019447..56094119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56203839..56273753)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7467 Neighboring gene STARR-seq mESC enhancer starr_41056 Neighboring gene SUMO1/sentrin specific peptidase 7 Neighboring gene predicted gene, 41462 Neighboring gene STARR-seq mESC enhancer starr_41058 Neighboring gene mitochondrial ribosomal protein L45 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41059 Neighboring gene STARR-seq mESC enhancer starr_41060 Neighboring gene STARR-seq mESC enhancer starr_41061 Neighboring gene STARR-seq mESC enhancer starr_41062 Neighboring gene STARR-seq mESC enhancer starr_41063 Neighboring gene STARR-seq mESC enhancer starr_41064 Neighboring gene discs, large homolog-associated protein 5 pseudogene Neighboring gene ABI family member 3 binding protein Neighboring gene STARR-seq mESC enhancer starr_41065 Neighboring gene STARR-seq mESC enhancer starr_41066 Neighboring gene STARR-seq mESC enhancer starr_41067

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis. Chen Q, et al. Exp Eye Res, 2003 Jan. PMID 12589770
  2. Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency. Mitchell B, et al. Sci Rep, 2022 Sep 15. PMID 36109576, Free PMC Article
  3. Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision. Salido EM, et al. J Neurosci, 2020 May 13. PMID 32265257, Free PMC Article
  4. Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice. Xu H, et al. Hum Mol Genet, 2020 Jun 27. PMID 32242237
  5. Spacrcan binding to hyaluronan and other glycosaminoglycans. Molecular and biochemical studies. Chen Q, et al. J Biol Chem, 2004 May 28. PMID 15044457

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
    Title: Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
  2. Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions.
    Title: Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions.
  3. Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
    Title: Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
  4. Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
    Title: Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
  5. May play an important role in photoreceptor development and maintenance.
    Title: SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in interphotoreceptor matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
interphotoreceptor matrix proteoglycan 2
Names
sialoprotein associated with cones and rods proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174876.3 → NP_777365.2  interphotoreceptor matrix proteoglycan 2 precursor

    See identical proteins and their annotated locations for NP_777365.2

    Status: VALIDATED

    Source sequence(s)
    AY174061, BC048863
    Consensus CDS
    CCDS37358.1
    UniProtKB/Swiss-Prot
    Q80XH2, Q810Y3, Q8C8E4
    Related
    ENSMUSP00000063648.8, ENSMUST00000069936.8
    Conserved Domains (2) summary
    smart00200
    Location:896 → 1018
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cl02507
    Location:235 → 345
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    56019447..56094119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316970.3 → XP_017172459.1  interphotoreceptor matrix proteoglycan 2 isoform X1

    Conserved Domains (2) summary
    smart00200
    Location:862 → 984
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cl02507
    Location:201 → 311
    SEA; SEA domain

  2. XM_017316971.3 → XP_017172460.1  interphotoreceptor matrix proteoglycan 2 isoform X2

    Conserved Domains (2) summary
    smart00200
    Location:855 → 977
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cl02507
    Location:201 → 304
    SEA; SEA domain

  3. XM_036159902.1 → XP_036015795.1  interphotoreceptor matrix proteoglycan 2 isoform X3

    Conserved Domains (1) summary
    smart00200
    Location:352 → 474
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XH2.1 GenPept UniProtKB/Swiss-Prot:Q80XH2

Gene LinkOut

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