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Nrros negative regulator of reactive oxygen species [ Mus musculus (house mouse) ]

Gene ID: 224109, updated on 11-Apr-2024

Summary

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Official Symbol
Nrrosprovided by MGI
Official Full Name
negative regulator of reactive oxygen speciesprovided by MGI
Primary source
MGI:MGI:2445095
See related
Ensembl:ENSMUSG00000052384 AllianceGenome:MGI:2445095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrcc33; Lrrc33; E430025L02Rik
Summary
Enables transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface and endoplasmic reticulum. Is expressed in embryo and thymus primordium. Orthologous to human NRROS (negative regulator of reactive oxygen species). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 34.1), thymus adult (RPKM 29.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Nrros in Genome Data Viewer
Location:
16 B2; 16 22.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31961603..31984412, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32142785..32165594, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene STARR-positive B cell enhancer ABC_E4165 Neighboring gene centrosomal protein 19 Neighboring gene STARR-seq mESC enhancer starr_40643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32130316-32130510 Neighboring gene STARR-positive B cell enhancer ABC_E7441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177054-32177400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177409-32177592 Neighboring gene STARR-seq mESC enhancer starr_40648 Neighboring gene brain expressed family member 6 Neighboring gene STARR-seq mESC enhancer starr_40649 Neighboring gene F-box protein 45 Neighboring gene predicted gene, 25848

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-N:B and Reactive Oxygen Species Pathways. Kim JH, et al. Mol Cells, 2015 Oct. PMID 26442864, Free PMC Article
  2. Biallelic mutations in NRROS cause an early onset lethal microgliopathy. Smith C, et al. Acta Neuropathol, 2020 May. PMID 32100099, Free PMC Article
  3. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. Su X, et al. J Leukoc Biol, 2014 Jul. PMID 24550525
  4. Mice deficient in NRROS show abnormal microglial development and neurological disorders. Wong K, et al. Nat Immunol, 2017 Jun. PMID 28459434
  5. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Qin Y, et al. Cell, 2018 Jun 28. PMID 29909984, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic mutations in NRROS cause an early onset lethal microgliopathy.
    Title: Biallelic mutations in NRROS cause an early onset lethal microgliopathy.
  2. NRROS-deficient (Nrros(-/-)) mice show defects in motor functions and die before 6 months of age. Nrros(-/-) mice display astrogliosis and lack normal CD11b(hi)CD45(lo) microglia, but they show no detectable demyelination or neuronal loss. perivascular macrophage-like myeloid cells populate the Nrros(-/-) CNS. Cx3cr1-driven deletion of Nrros shows its crucial role in microglial establishment during early embryonic stages.
    Title: Mice deficient in NRROS show abnormal microglial development and neurological disorders.
  3. this study presents NRROS as a novel negative regulator of RANKL-induced osteoclastogenesis.
    Title: NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-N:B and Reactive Oxygen Species Pathways.
  4. results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis.
    Title: Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.
  5. NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage
    Title: NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC36838

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microglia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of TGFbeta in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in superoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming growth factor beta activator LRRC33
Names
leucine rich repeat containing 33
leucine-rich repeat-containing protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347181.1 → NP_001334110.1  transforming growth factor beta activator LRRC33 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC135962, BG230063
    Consensus CDS
    CCDS84220.1
    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Related
    ENSMUSP00000097571.5, ENSMUST00000099991.11
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

  2. NM_001347182.1 → NP_001334111.1  transforming growth factor beta activator LRRC33 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC135962, BG230063
    Consensus CDS
    CCDS84221.1
    UniProtKB/TrEMBL
    A0A338P6E7
    Related
    ENSMUSP00000110819.4, ENSMUST00000115165.10

  3. NM_146069.5 → NP_666181.3  transforming growth factor beta activator LRRC33 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (2).
    Source sequence(s)
    AC135962, AK084858, BG230063, BY194080
    Consensus CDS
    CCDS84220.1
    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Related
    ENSMUSP00000119349.2, ENSMUST00000143682.8
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31961603..31984412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522075.1 → XP_006522138.1  transforming growth factor beta activator LRRC33 isoform X1

    See identical proteins and their annotated locations for XP_006522138.1

    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

  2. XM_006522074.4 → XP_006522137.1  transforming growth factor beta activator LRRC33 isoform X1

    See identical proteins and their annotated locations for XP_006522137.1

    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

  3. XM_006522077.4 → XP_006522140.1  transforming growth factor beta activator LRRC33 isoform X1

    See identical proteins and their annotated locations for XP_006522140.1

    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

  4. XM_017316962.3 → XP_017172451.1  transforming growth factor beta activator LRRC33 isoform X1

    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

  5. XM_036159896.1 → XP_036015789.1  transforming growth factor beta activator LRRC33 isoform X1

    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

  6. XM_006522076.4 → XP_006522139.1  transforming growth factor beta activator LRRC33 isoform X1

    See identical proteins and their annotated locations for XP_006522139.1

    UniProtKB/Swiss-Prot
    Q3TIA8, Q8BMT4, Q8BTT4, Q8BUI7, Q8BY16, Q8R063
    UniProtKB/TrEMBL
    A0A338P6E7
    Conserved Domains (3) summary
    PLN00113
    Location:60 → 439
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMT4.2 GenPept UniProtKB/Swiss-Prot:Q8BMT4

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