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Atp13a3 ATPase type 13A3 [ Mus musculus (house mouse) ]

Gene ID: 224088, updated on 11-Apr-2024

Summary

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Official Symbol
Atp13a3provided by MGI
Official Full Name
ATPase type 13A3provided by MGI
Primary source
MGI:MGI:2685387
See related
Ensembl:ENSMUSG00000022533 AllianceGenome:MGI:2685387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm541; Gm542; Gm1745
Summary
Predicted to enable ABC-type putrescine transporter activity. Predicted to be involved in cellular calcium ion homeostasis. Predicted to be located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Orthologous to human ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 11.5), placenta adult (RPKM 10.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B2; 16 21.26 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30131241..30207674, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30312423..30388871, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein 5 platelet Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30389389-30389616 Neighboring gene STARR-seq mESC enhancer starr_40576 Neighboring gene STARR-seq mESC enhancer starr_40579 Neighboring gene transmembrane protein 44 Neighboring gene STARR-seq mESC enhancer starr_40580 Neighboring gene predicted gene, 52252 Neighboring gene STARR-seq mESC enhancer starr_40581 Neighboring gene STARR-seq mESC enhancer starr_40582 Neighboring gene predicted gene, 53946 Neighboring gene large 60S subunit nuclear export GTPase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the P5 subfamily of P-type transport ATPases in mice. Schultheis PJ, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381061
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type putrescine transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables polyamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyamine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyamine-transporting ATPase 13A3
Names
probable cation-transporting ATPase 13A3
putrescine transporting ATPase
type V P-type ATPase
NP_001121566.1
NP_001121568.1
XP_011244181.1
XP_036015785.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128094.1 → NP_001121566.1  polyamine-transporting ATPase 13A3 isoform 2

    See identical proteins and their annotated locations for NP_001121566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC154608, BK005558
    Consensus CDS
    CCDS49820.1
    UniProtKB/Swiss-Prot
    Q5XF89
    Related
    ENSMUSP00000051645.7, ENSMUST00000061350.13
    Conserved Domains (6) summary
    TIGR01657
    Location:14 → 1142
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:232 → 479
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:174 → 222
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13 → 141
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:618 → 658
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:817 → 894
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001128096.1 → NP_001121568.1  polyamine-transporting ATPase 13A3 isoform 1

    See identical proteins and their annotated locations for NP_001121568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154608
    Consensus CDS
    CCDS49821.1
    UniProtKB/Swiss-Prot
    Q5XF89
    Related
    ENSMUSP00000128224.2, ENSMUST00000100013.9
    Conserved Domains (1) summary
    TIGR01657
    Location:14 → 1142
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    30131241..30207674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245879.4 → XP_011244181.1  polyamine-transporting ATPase 13A3 isoform X2

    Conserved Domains (1) summary
    TIGR01657
    Location:14 → 1115
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  2. XM_036159892.1 → XP_036015785.1  polyamine-transporting ATPase 13A3 isoform X1

    Conserved Domains (1) summary
    TIGR01657
    Location:14 → 1142
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

RNA

  1. XR_004939186.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XF89.1 GenPept UniProtKB/Swiss-Prot:Q5XF89

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