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Wnt1 wingless-type MMTV integration site family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 22408, updated on 9-Dec-2024

Summary

Official Symbol
Wnt1provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 1provided by MGI
Primary source
MGI:MGI:98953
See related
Ensembl:ENSMUSG00000022997 AllianceGenome:MGI:98953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sw; Int-1; Wnt-1; swaying
Summary
Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; embryonic brain development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including nervous system development; positive regulation of hematopoietic stem cell proliferation; and regulation of protein metabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E11.5 (RPKM 2.1), testis adult (RPKM 1.8) and 5 other tissues See more
Orthologs
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Genomic context

See Wnt1 in Genome Data Viewer
Location:
15 F1; 15 54.65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98687738..98691711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98789857..98793830)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ARF GTPase 3 Neighboring gene uncharacterized LOC115488470 Neighboring gene wingless-type MMTV integration site family, member 10B Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables frizzled binding  
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables receptor ligand activity PubMed 
enables receptor ligand activity  
enables signaling receptor binding PubMed 
enables signaling receptor binding PubMed 
Items 1 - 25 of 98
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway PubMed 
involved_in Spemann organizer formation PubMed 
acts_upstream_of_or_within T cell differentiation in thymus PubMed 
involved_in Wnt signaling pathway PubMed 
acts_upstream_of_or_within animal organ morphogenesis PubMed 
involved_in animal organ regeneration  
involved_in animal organ regeneration  
involved_in astrocyte-dopaminergic neuron signaling PubMed 
involved_in bone development  
involved_in bone development  
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
involved_in canonical Wnt signaling pathway  
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in cell fate commitment  
acts_upstream_of cell population proliferation PubMed 
involved_in cell proliferation in midbrain PubMed 
involved_in cell-cell signaling PubMed 
acts_upstream_of_or_within cell-cell signaling PubMed 
involved_in cellular response to peptide hormone stimulus  
involved_in central nervous system morphogenesis PubMed 
involved_in cerebellum development PubMed 
involved_in cerebellum formation PubMed 
acts_upstream_of_or_within diencephalon development PubMed 
involved_in dopaminergic neuron differentiation PubMed 
involved_in dopaminergic neuron differentiation PubMed 
involved_in embryonic axis specification PubMed 
involved_in embryonic brain development PubMed 
acts_upstream_of fat cell differentiation PubMed 
acts_upstream_of_or_within forebrain anterior/posterior pattern specification PubMed 
acts_upstream_of hematopoietic stem cell proliferation PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation PubMed 
involved_in hepatocyte differentiation  
involved_in hepatocyte differentiation  
acts_upstream_of_or_within inner ear morphogenesis PubMed 
acts_upstream_of_or_within metencephalon development PubMed 
involved_in midbrain development PubMed 
acts_upstream_of_or_within midbrain development PubMed 
involved_in midbrain development PubMed 
involved_in midbrain dopaminergic neuron differentiation PubMed 
involved_in midbrain dopaminergic neuron differentiation PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary maturation during brain development PubMed 
acts_upstream_of_or_within myoblast fusion PubMed 
acts_upstream_of_or_within myoblast fusion PubMed 
acts_upstream_of_or_within myotube differentiation PubMed 
involved_in negative regulation of BMP signaling pathway  
involved_in negative regulation of BMP signaling pathway  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cell differentiation PubMed 
involved_in negative regulation of cell-cell adhesion  
involved_in negative regulation of cell-cell adhesion  
involved_in negative regulation of cell-substrate adhesion  
involved_in negative regulation of cell-substrate adhesion  
involved_in negative regulation of cellular senescence  
involved_in negative regulation of cellular senescence  
acts_upstream_of_or_within negative regulation of fat cell differentiation PubMed 
involved_in negative regulation of fat cell differentiation PubMed 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process PubMed 
involved_in neurogenesis PubMed 
involved_in neuron differentiation  
acts_upstream_of_or_within neuron fate commitment PubMed 
acts_upstream_of_or_within neuron fate determination PubMed 
involved_in positive regulation of DNA-binding transcription factor activity PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of Notch signaling pathway  
involved_in positive regulation of Notch signaling pathway  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of dermatome development  
involved_in positive regulation of dermatome development  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of fibroblast proliferation  
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation PubMed 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway  
involved_in positive regulation of insulin-like growth factor receptor signaling pathway  
involved_in positive regulation of lamellipodium assembly  
involved_in positive regulation of lamellipodium assembly  
acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in regulation of DNA-templated transcription PubMed 
involved_in response to wounding  
acts_upstream_of_or_within signal transduction PubMed 
involved_in signal transduction in response to DNA damage  
involved_in signal transduction in response to DNA damage  
acts_upstream_of_or_within spinal cord association neuron differentiation PubMed 
Items 1 - 25 of 98
Component Evidence Code Pubs
part_of Wnt signalosome PubMed 
located_in cell surface PubMed 
located_in cytoplasm  
located_in endoplasmic reticulum lumen  
located_in extracellular region PubMed 
is_active_in extracellular space  

General protein information

Preferred Names
proto-oncogene Wnt-1
Names
proto-oncogene Int-1
proto-oncogene protein Wnt-1
wingless-related MMTV integration site 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021279.4NP_067254.1  proto-oncogene Wnt-1 precursor

    See identical proteins and their annotated locations for NP_067254.1

    Status: VALIDATED

    Source sequence(s)
    AC156543, AK141669
    Consensus CDS
    CCDS27807.1
    UniProtKB/Swiss-Prot
    P04426
    UniProtKB/TrEMBL
    Q3UR96
    Related
    ENSMUSP00000023734.8, ENSMUST00000023734.8
    Conserved Domains (1) summary
    smart00097
    Location:60370
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98687738..98691711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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