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Wiz widely-interspaced zinc finger motifs [ Mus musculus (house mouse) ]

Gene ID: 22404, updated on 21-Apr-2024

Summary

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Official Symbol
Wizprovided by MGI
Official Full Name
widely-interspaced zinc finger motifsprovided by MGI
Primary source
MGI:MGI:1332638
See related
Ensembl:ENSMUSG00000024050 AllianceGenome:MGI:1332638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables SET domain binding activity and histone methyltransferase binding activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication; protein stabilization; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human WIZ (WIZ zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 12.4), CNS E14 (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.52 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32573021..32608463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32354047..32389501, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E5590 Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8-like Neighboring gene STARR-positive B cell enhancer ABC_E1502 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32506256-32506557 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32508595-32508896 Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene predicted gene, 53995 Neighboring gene RAS protein activator like 3 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene predicted gene, 41569 Neighboring gene peptidoglycan recognition protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. Baust C, et al. Mamm Genome, 2002 Aug. PMID 12226707
  2. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. Matsumoto K, et al. Brain Res Mol Brain Res, 1998 Oct 30. PMID 9795207
  3. Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. Isbel L, et al. Elife, 2016 Jul 13. PMID 27410475, Free PMC Article
  4. Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11. Funke B, et al. Genomics, 1998 Oct 15. PMID 9790763
  5. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. Ueda J, et al. J Biol Chem, 2006 Jul 21. PMID 16702210

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites.
    Title: Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse.
  2. Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells.
    Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables SET domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Wiz
Names
widely-interspaced zinc finger-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372219.1 → NP_001359148.1  protein Wiz isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  2. NM_001372220.1 → NP_001359149.1  protein Wiz isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  3. NM_001372221.1 → NP_001359150.1  protein Wiz isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  4. NM_001372222.1 → NP_001359151.1  protein Wiz isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT033751
    UniProtKB/TrEMBL
    F6ZBR8
    Related
    ENSMUSP00000126253.4, ENSMUST00000169488.10

  5. NM_001372223.1 → NP_001359152.1  protein Wiz isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT033751

  6. NM_001372224.1 → NP_001359153.1  protein Wiz isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616
    Consensus CDS
    CCDS28617.2
    Related
    ENSMUSP00000069443.8, ENSMUST00000064694.14

  7. NM_001372225.1 → NP_001359154.1  protein Wiz isoform 8

    Status: VALIDATED

    Source sequence(s)
    CT033751

  8. NM_001372226.1 → NP_001359155.1  protein Wiz isoform 9

    Status: VALIDATED

    Source sequence(s)
    CT033751

  9. NM_001372227.1 → NP_001359156.1  protein Wiz isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616
    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    UniProtKB/TrEMBL
    A0A494BAG6
    Related
    ENSMUSP00000158082.2, ENSMUST00000236409.2
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001410390.1 → NP_001397319.1  protein Wiz isoform 15

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  11. NM_001410391.1 → NP_001397320.1  protein Wiz isoform 12

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  12. NM_001410392.1 → NP_001397321.1  protein Wiz isoform 12

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  13. NM_001410393.1 → NP_001397322.1  protein Wiz isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  14. NM_001410394.1 → NP_001397323.1  protein Wiz isoform 10

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  15. NM_001410395.1 → NP_001397324.1  protein Wiz isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  16. NM_001410396.1 → NP_001397325.1  protein Wiz isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  17. NM_001410397.1 → NP_001397326.1  protein Wiz isoform 16

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  18. NM_001410398.1 → NP_001397327.1  protein Wiz isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  19. NM_001410399.1 → NP_001397328.1  protein Wiz isoform 8

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  20. NM_001410400.1 → NP_001397329.1  protein Wiz isoform 13

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  21. NM_001410401.1 → NP_001397330.1  protein Wiz isoform 13

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  22. NM_001410402.1 → NP_001397331.1  protein Wiz isoform 19

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  23. NM_001410403.1 → NP_001397332.1  protein Wiz isoform 14

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  24. NM_001410404.1 → NP_001397333.1  protein Wiz isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  25. NM_001410405.1 → NP_001397334.1  protein Wiz isoform 20

    Status: VALIDATED

    Source sequence(s)
    CT033751

  26. NM_001410406.1 → NP_001397335.1  protein Wiz isoform 17

    Status: VALIDATED

    Source sequence(s)
    CT033751

  27. NM_001410407.1 → NP_001397336.1  protein Wiz isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT033751

  28. NM_001410408.1 → NP_001397337.1  protein Wiz isoform 14

    Status: VALIDATED

    Source sequence(s)
    CT033751

  29. NM_001410409.1 → NP_001397338.1  protein Wiz isoform 21

    Status: VALIDATED

    Source sequence(s)
    CT033751

  30. NM_001410410.1 → NP_001397339.1  protein Wiz isoform 18

    Status: VALIDATED

    Source sequence(s)
    CT033751

  31. NM_001423683.1 → NP_001410612.1  protein Wiz isoform 22

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616

  32. NM_011717.5 → NP_035847.2  protein Wiz isoform 2

    See identical proteins and their annotated locations for NP_035847.2

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616
    Consensus CDS
    CCDS28616.1
    UniProtKB/TrEMBL
    G5E8J8
    Related
    ENSMUSP00000084993.6, ENSMUST00000087703.12

  33. NM_212438.4 → NP_997603.3  protein Wiz isoform 1

    See identical proteins and their annotated locations for NP_997603.3

    Status: VALIDATED

    Source sequence(s)
    CT033751, CT485616
    Consensus CDS
    CCDS28617.2
    UniProtKB/Swiss-Prot
    O88286

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32573021..32608463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317402.2 → XP_017172891.1  protein Wiz isoform X18

  2. XM_011246380.2 → XP_011244682.1  protein Wiz isoform X9

    See identical proteins and their annotated locations for XP_011244682.1

  3. XM_036160496.1 → XP_036016389.1  protein Wiz isoform X4

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036160489.1 → XP_036016382.1  protein Wiz isoform X1

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006524063.2 → XP_006524126.1  protein Wiz isoform X9

    See identical proteins and their annotated locations for XP_006524126.1

  6. XM_030249670.2 → XP_030105530.1  protein Wiz isoform X19

  7. XM_030249660.2 → XP_030105520.1  protein Wiz isoform X12

  8. XM_006524053.3 → XP_006524116.1  protein Wiz isoform X6

    See identical proteins and their annotated locations for XP_006524116.1

  9. XM_006524057.3 → XP_006524120.1  protein Wiz isoform X7

    See identical proteins and their annotated locations for XP_006524120.1

  10. XM_036160493.1 → XP_036016386.1  protein Wiz isoform X3

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_036160498.1 → XP_036016391.1  protein Wiz isoform X5

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. XM_036160492.1 → XP_036016385.1  protein Wiz isoform X2

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. XM_036160488.1 → XP_036016381.1  protein Wiz isoform X1

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. XM_006524055.2 → XP_006524118.1  protein Wiz isoform X6

    See identical proteins and their annotated locations for XP_006524118.1

  15. XM_036160491.1 → XP_036016384.1  protein Wiz isoform X1

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. XM_036160497.1 → XP_036016390.1  protein Wiz isoform X4

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. XM_030249659.1 → XP_030105519.1  protein Wiz isoform X11

  18. XM_030249657.1 → XP_030105517.1  protein Wiz isoform X11

  19. XM_011246379.1 → XP_011244681.1  protein Wiz isoform X9

    See identical proteins and their annotated locations for XP_011244681.1

  20. XM_036160494.1 → XP_036016387.1  protein Wiz isoform X4

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  21. XM_036160500.1 → XP_036016393.1  protein Wiz isoform X11

  22. XM_030249654.1 → XP_030105514.1  protein Wiz isoform X9

  23. XM_036160495.1 → XP_036016388.1  protein Wiz isoform X4

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  24. XM_006524062.2 → XP_006524125.1  protein Wiz isoform X8

    See identical proteins and their annotated locations for XP_006524125.1

  25. XM_036160490.1 → XP_036016383.1  protein Wiz isoform X1

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  26. XM_006524056.3 → XP_006524119.1  protein Wiz isoform X6

    See identical proteins and their annotated locations for XP_006524119.1

  27. XM_030249655.2 → XP_030105515.2  protein Wiz isoform X4

    UniProtKB/Swiss-Prot
    O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
    Conserved Domains (1) summary
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212437.1: Suppressed sequence

    Description
    NM_212437.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88286.2 GenPept UniProtKB/Swiss-Prot:O88286

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