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Klhl22 kelch-like 22 [ Mus musculus (house mouse) ]

Gene ID: 224023, updated on 11-Apr-2024

Summary

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Official Symbol
Klhl22provided by MGI
Official Full Name
kelch-like 22provided by MGI
Primary source
MGI:MGI:1337995
See related
Ensembl:ENSMUSG00000022750 AllianceGenome:MGI:1337995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kelchl; 2610318I18Rik
Summary
Predicted to enable 14-3-3 protein binding activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; intercellular bridge; and microtubule cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and microtubule cytoskeleton. Predicted to colocalize with lysosome and nucleus. Orthologous to human KLHL22 (kelch like family member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 28.6), ovary adult (RPKM 22.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 11.01 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17577485..17611246)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17759621..17793382)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 8 Neighboring gene biorientation of chromosomes in cell division 1, pseudogene Neighboring gene scavenger receptor class F, member 2 Neighboring gene VISTA enhancer mm1629 Neighboring gene zinc finger protein 520, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. Zhou XA, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33109719, Free PMC Article
  2. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Chen J, et al. Nature, 2018 May. PMID 29769719
  3. Analysis of cDNA sequences from mouse testis. Kerr SM, et al. Mamm Genome, 1994 Sep. PMID 8000140
  4. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. Kong X, et al. Development, 2022 Dec 15. PMID 36440598, Free PMC Article
  5. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2. Lund J, et al. Genomics, 2000 Feb 1. PMID 10704284

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
    Title: Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in polar microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in polar microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359068.1 → NP_001345997.1  kelch-like protein 22 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC087802
    Consensus CDS
    CCDS49783.1
    UniProtKB/Swiss-Prot
    D3YW27, Q8BT13, Q99JN2
    Related
    ENSMUSP00000112412.2, ENSMUST00000120488.3
    Conserved Domains (4) summary
    PHA03098
    Location:52 → 592
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:340 → 385
    Kelch; KELCH repeat [structural motif]
    cd18251
    Location:27 → 151
    BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
    cd18461
    Location:147 → 250
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

  2. NM_001379022.1 → NP_001365951.1  kelch-like protein 22 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087802
    UniProtKB/Swiss-Prot
    D3YW27, Q8BT13, Q99JN2
    Conserved Domains (4) summary
    PHA03098
    Location:52 → 592
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:340 → 385
    Kelch; KELCH repeat [structural motif]
    cd18251
    Location:27 → 151
    BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
    cd18461
    Location:147 → 250
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

  3. NM_001379023.1 → NP_001365952.1  kelch-like protein 22 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087802
    UniProtKB/Swiss-Prot
    D3YW27, Q8BT13, Q99JN2
    Conserved Domains (4) summary
    PHA03098
    Location:52 → 592
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:340 → 385
    Kelch; KELCH repeat [structural motif]
    cd18251
    Location:27 → 151
    BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
    cd18461
    Location:147 → 250
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

  4. NM_001379024.1 → NP_001365953.1  kelch-like protein 22 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087802
    Conserved Domains (4) summary
    PHA03098
    Location:71 → 611
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 404
    Kelch; KELCH repeat [structural motif]
    cd18251
    Location:46 → 170
    BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
    cd18461
    Location:166 → 269
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

  5. NM_001379025.1 → NP_001365954.1  kelch-like protein 22 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087802, AK030669
    UniProtKB/TrEMBL
    Q8CDC1
    Conserved Domains (3) summary
    sd00038
    Location:294 → 335
    Kelch; KELCH repeat [structural motif]
    cd18461
    Location:147 → 250
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
    cl38908
    Location:27 → 151
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  6. NM_001379026.1 → NP_001365955.1  kelch-like protein 22 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087802
    UniProtKB/TrEMBL
    Q8CDC1
    Conserved Domains (3) summary
    sd00038
    Location:294 → 335
    Kelch; KELCH repeat [structural motif]
    cd18461
    Location:147 → 250
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
    cl38908
    Location:27 → 151
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  7. NM_145479.4 → NP_663454.3  kelch-like protein 22 isoform 1

    See identical proteins and their annotated locations for NP_663454.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI845204, AK143514, CJ159851
    Consensus CDS
    CCDS49783.1
    UniProtKB/Swiss-Prot
    D3YW27, Q8BT13, Q99JN2
    Related
    ENSMUSP00000127227.2, ENSMUST00000165790.9
    Conserved Domains (4) summary
    PHA03098
    Location:52 → 592
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:340 → 385
    Kelch; KELCH repeat [structural motif]
    cd18251
    Location:27 → 151
    BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)
    cd18461
    Location:147 → 250
    BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

RNA

  1. NR_166418.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087802

  2. NR_166419.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087802

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17577485..17611246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JN2.1 GenPept UniProtKB/Swiss-Prot:Q99JN2

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