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Rmi2 RecQ mediated genome instability 2 [ Mus musculus (house mouse) ]

Gene ID: 223970, updated on 5-Mar-2024

Summary

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Official Symbol
Rmi2provided by MGI
Official Full Name
RecQ mediated genome instability 2provided by MGI
Primary source
MGI:MGI:2685383
See related
Ensembl:ENSMUSG00000037991 AllianceGenome:MGI:2685383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm537; Gm929; A630055G03Rik
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and regulation of sister chromatid segregation. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be active in cytosol and nuclear speck. Is expressed in axial skeleton; bladder; and rib. Orthologous to human RMI2 (RecQ mediated genome instability 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 9.9), CNS E11.5 (RPKM 2.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 6.06 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10652923..10661099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10835059..10843235)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40096 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10806282-10806483 Neighboring gene protamine 1 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10814996-10815179 Neighboring gene STARR-positive B cell enhancer ABC_E8907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10836584-10836853 Neighboring gene cyclin Y-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10844126-10844349 Neighboring gene predicted gene, 53936 Neighboring gene predicted gene, 21859

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome instability and embryonic developmental defects in RMI1 deficient mice. Guiraldelli MF, et al. DNA Repair (Amst), 2013 Oct. PMID 23900276, Free PMC Article
  2. Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex. Xue X, et al. J Biol Chem, 2013 May 17. PMID 23543748, Free PMC Article
  3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of rDNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of DNA recombination intermediates ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RecQ family helicase-topoisomerase III complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
recQ-mediated genome instability protein 2
Names
RMI2, RecQ mediated genome instability 2, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162932.1 → NP_001156404.1  recQ-mediated genome instability protein 2

    See identical proteins and their annotated locations for NP_001156404.1

    Status: VALIDATED

    Source sequence(s)
    CT010583
    Consensus CDS
    CCDS49761.1
    UniProtKB/Swiss-Prot
    Q3UPE3, Q3V2Y5
    Related
    ENSMUSP00000042676.8, ENSMUST00000037913.9
    Conserved Domains (1) summary
    pfam16100
    Location:24 → 143
    RMI2; RecQ-mediated genome instability protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10652923..10661099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033278.1: Suppressed sequence

    Description
    NM_001033278.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UPE3.1 GenPept UniProtKB/Swiss-Prot:Q3UPE3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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