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Wbp2 WW domain binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 22378, updated on 5-Mar-2024

Summary

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Official Symbol
Wbp2provided by MGI
Official Full Name
WW domain binding protein 2provided by MGI
Primary source
MGI:MGI:104709
See related
Ensembl:ENSMUSG00000034341 AllianceGenome:MGI:104709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA binding activity; estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of macromolecule metabolic process; and response to steroid hormone. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. Is expressed in epidermis and epidermis stratum basale. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to human WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 171.5), duodenum adult (RPKM 125.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115969397..115977821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116078571..116086995, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31192 Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D Neighboring gene STARR-positive B cell enhancer ABC_E10732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115939592-115939779 Neighboring gene STARR-positive B cell enhancer ABC_E381 Neighboring gene STARR-positive B cell enhancer ABC_E8471 Neighboring gene STARR-seq mESC enhancer starr_31193 Neighboring gene tripartite motif-containing 47 Neighboring gene tripartite motif-containing 65

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1. Zheng Z, et al. Cell Death Dis, 2021 Mar 3. PMID 33658485, Free PMC Article
  2. Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. Buniello A, et al. EMBO Mol Med, 2016 Mar 1. PMID 26881968, Free PMC Article
  3. Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2 protein stability. Field NS, et al. Eur J Immunol, 2020 Oct. PMID 32459862, Free PMC Article
  4. Characterization of a novel protein-binding module--the WW domain. Sudol M, et al. FEBS Lett, 1995 Aug 1. PMID 7641887
  5. Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway. Lim SK, et al. FASEB J, 2011 Sep. PMID 21642474

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKbeta1.
    Title: WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1.
  2. This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk.
    Title: Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to progesterone ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WW domain-binding protein 2
Names
WBP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347642.1 → NP_001334571.1  WW domain-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI837765, AI844895, AK043037, AL607108, DV657565
    Consensus CDS
    CCDS83934.1
    UniProtKB/Swiss-Prot
    P97765
    UniProtKB/TrEMBL
    Q544A1
    Related
    ENSMUSP00000102052.4, ENSMUST00000106444.4

  2. NM_001361446.1 → NP_001348375.1  WW domain-binding protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant. 1. The encoded isoform (3) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL607108
    Conserved Domains (1) summary
    cd13214
    Location:30 → 131
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  3. NM_016852.3 → NP_058548.1  WW domain-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_058548.1

    Status: VALIDATED

    Source sequence(s)
    AL607108
    Consensus CDS
    CCDS25657.1
    UniProtKB/Swiss-Prot
    A2A860, P97765
    UniProtKB/TrEMBL
    Q3TRG5, Q544A1
    Related
    ENSMUSP00000074204.7, ENSMUST00000074628.13
    Conserved Domains (1) summary
    cd13214
    Location:30 → 131
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115969397..115977821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97765.1 GenPept UniProtKB/Swiss-Prot:P97765

Gene LinkOut

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