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Brd1 bromodomain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 223770, updated on 21-Apr-2024

Summary

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Official Symbol
Brd1provided by MGI
Official Full Name
bromodomain containing 1provided by MGI
Primary source
MGI:MGI:1924161
See related
Ensembl:ENSMUSG00000022387 AllianceGenome:MGI:1924161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4191; 1110059H06Rik
Summary
Predicted to enable histone binding activity. Involved in histone H3-K14 acetylation and positive regulation of erythrocyte differentiation. Part of histone H3-K14 acetyltransferase complex. Is expressed in brain; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.6), CNS E14 (RPKM 5.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 44.17 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88571237..88618508, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (88687034..88734228, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA methionine 4 (anticodon CAT) Neighboring gene predicted gene, 35997 Neighboring gene STARR-seq mESC enhancer starr_39439 Neighboring gene STARR-positive B cell enhancer ABC_E9918 Neighboring gene STARR-positive B cell enhancer ABC_E5507 Neighboring gene zinc finger, BED type containing 4 Neighboring gene STARR-seq mESC enhancer starr_39444 Neighboring gene STARR-positive B cell enhancer ABC_E391 Neighboring gene ALG12 alpha-1,6-mannosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping. Paternoster V, et al. Mol Neurobiol, 2021 Sep. PMID 34056693
  2. Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. Rajkumar AP, et al. Transl Psychiatry, 2020 Jul 17. PMID 32681022, Free PMC Article
  3. Brain proteome changes in female Brd1(+/-) mice unmask dendritic spine pathology and show enrichment for schizophrenia risk. Paternoster V, et al. Neurobiol Dis, 2019 Apr. PMID 30590179
  4. Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia. Qvist P, et al. Neurobiol Learn Mem, 2017 May. PMID 28341151
  5. Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq. Rajkumar AP, et al. BMC Genomics, 2015 Jul 25. PMID 26208977, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.
    Title: Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.
  2. Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
    Title: Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
  3. Brd1(+/-) mice exhibit relational encoding deficits, compromised working and long term memory, as well as impaired executive cognitive functioning with cognitive behaviors relying on medial prefrontal cortex being particularly affected. Akin to patients with schizophrenia, the cognitive deficits displayed by Brd1(+/)(-) mice are not global, but selective.
    Title: Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
  4. results demonstrate widespread gene expression alterations in the brains of Brd1 +/- mice.
    Title: The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice.
  5. BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
    Title: The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells.
  6. Brd1-mediated Hbo1 activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.
    Title: Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
  7. The Hbo1-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator genes.
    Title: The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4191, MGC164733

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
part_of histone H3-K14 acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone H3-K14 acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain-containing protein 1
Names
bromodomain and PHD finger-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033274.3 → NP_001028446.2  bromodomain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AK149714, AK220233, BB610711, BC037388, BC152356
    Consensus CDS
    CCDS27730.2
    UniProtKB/TrEMBL
    A7MCW6, E9PZ26, Q3UE68, Q571F6
    Related
    ENSMUSP00000105007.2, ENSMUST00000109381.9
    Conserved Domains (5) summary
    cd05839
    Location:1058 → 1173
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15677
    Location:214 → 267
    PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    88571237..88618508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248510.2 → XP_030104370.1  bromodomain-containing protein 1 isoform X4

    Conserved Domains (5) summary
    cd05839
    Location:897 → 1012
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    COG5141
    Location:139 → 572
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like
    cl02556
    Location:566 → 633
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  2. XM_006520834.4 → XP_006520897.1  bromodomain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    cd05839
    Location:1028 → 1143
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    COG5141
    Location:139 → 572
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like
    cl02556
    Location:566 → 633
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  3. XM_006520836.4 → XP_006520899.1  bromodomain-containing protein 1 isoform X5

    Conserved Domains (5) summary
    cd05839
    Location:892 → 1007
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 572
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  4. XM_006520835.4 → XP_006520898.1  bromodomain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006520898.1

    UniProtKB/Swiss-Prot
    E9PZ26, G5E8P1, Q571F6, Q8BU83
    Related
    ENSMUSP00000105006.2, ENSMUST00000109380.8
    Conserved Domains (5) summary
    cd05839
    Location:927 → 1042
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 572
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  5. XM_036159368.1 → XP_036015261.1  bromodomain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd05839
    Location:1047 → 1162
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 572
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

RNA

  1. XR_004938826.1 RNA Sequence

  2. XR_384007.4 RNA Sequence

  3. XR_004938828.1 RNA Sequence

  4. XR_384008.4 RNA Sequence

  5. XR_004938827.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8P1.1 GenPept UniProtKB/Swiss-Prot:G5E8P1

Gene LinkOut

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Chemical Information
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