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Mrtfa myocardin related transcription factor A [ Mus musculus (house mouse) ]

Gene ID: 223701, updated on 5-Mar-2024

Summary

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Official Symbol
Mrtfaprovided by MGI
Official Full Name
myocardin related transcription factor Aprovided by MGI
Primary source
MGI:MGI:2384495
See related
Ensembl:ENSMUSG00000042292 AllianceGenome:MGI:2384495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mal; AMKL; Bsac; Mkl1; Mrtf-A
Summary
Enables several functions, including DNA-binding transcription factor activity; actin monomer binding activity; and transcription coactivator activity. Involved in actin cytoskeleton organization and positive regulation of transcription via serum response element binding activity. Acts upstream of or within negative regulation of apoptotic process; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in cerebellum; early conceptus; liver; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 34.3), thymus adult (RPKM 29.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.98 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80896482..81074937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81012281..81190736, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6612 Neighboring gene adenylosuccinate lyase Neighboring gene small G protein signaling modulator 3 Neighboring gene STARR-seq mESC enhancer starr_39247 Neighboring gene predicted gene, 31462 Neighboring gene predicted gene, 25131 Neighboring gene STARR-seq mESC enhancer starr_39250 Neighboring gene RIKEN cDNA 4930483J18 gene Neighboring gene STARR-positive B cell enhancer ABC_E943 Neighboring gene predicted gene, 49537

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice. Liu L, et al. Life Sci, 2023 Mar 15. PMID 36758668
  2. MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription. Wu T, et al. Redox Biol, 2023 Feb. PMID 36587486, Free PMC Article
  3. MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models. Zhang W, et al. Aging (Albany NY), 2022 May 23. PMID 35604830, Free PMC Article
  4. MRTF-A regulates myoblast commitment to differentiation by targeting PAX7 during muscle regeneration. Song R, et al. J Cell Mol Med, 2021 Sep. PMID 34347392, Free PMC Article
  5. Therapeutic effects of myocardin-related transcription factor A (MRTF-A) knockout on experimental mice with nonalcoholic steatohepatitis induced by high-fat diet. Zhang L, et al. Hum Exp Toxicol, 2021 Oct. PMID 33779332

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium.
    Title: MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium.
  2. An MRTF-A-ZEB1-IRF9 axis contributes to fibroblast-myofibroblast transition and renal fibrosis.
    Title: An MRTF-A-ZEB1-IRF9 axis contributes to fibroblast-myofibroblast transition and renal fibrosis.
  3. Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice.
    Title: Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice.
  4. MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription.
    Title: MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription.
  5. MRTF-A-mediated protection against amyloid-beta-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models.
    Title: MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models.
  6. Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice.
    Title: Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice.
  7. Lamina-associated polypeptide 2alpha is required for intranuclear MRTF-A activity.
    Title: Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity.
  8. MRTF-A regulates myoblast commitment to differentiation by targeting PAX7 during muscle regeneration.
    Title: MRTF-A regulates myoblast commitment to differentiation by targeting PAX7 during muscle regeneration.
  9. Therapeutic effects of myocardin-related transcription factor A (MRTF-A) knockout on experimental mice with nonalcoholic steatohepatitis induced by high-fat diet.
    Title: Therapeutic effects of myocardin-related transcription factor A (MRTF-A) knockout on experimental mice with nonalcoholic steatohepatitis induced by high-fat diet.
  10. Lamin A/C-Dependent Translocation of Megakaryoblastic Leukemia-1 and beta-Catenin in Cyclic Strain-Induced Osteogenesis.
    Title: Lamin A/C-Dependent Translocation of Megakaryoblastic Leukemia-1 and β-Catenin in Cyclic Strain-Induced Osteogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myocardin-related transcription factor A
Names
MKL (megakaryoblastic leukemia)/myocardin-like 1
MKL/myocardin-like protein 1
basic SAP and coiled-coil domains
basic SAP coiled-coil transcription activator
megakaryoblastic leukemia (translocation) 1 homolog
megakaryocytic acute leukemia protein homolog
myocardial related transcription factor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082536.2 → NP_001076005.2  myocardin-related transcription factor A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1. This variant uses a non-AUG translation start codon.
    Source sequence(s)
    AC102198, AC141880
    Consensus CDS
    CCDS49674.2
    UniProtKB/TrEMBL
    A0A5F8MQ33, D3YUI2
    Related
    ENSMUSP00000159052.2, ENSMUST00000239114.2
    Conserved Domains (2) summary
    smart00707
    Location:168 → 193
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:453 → 483
    SAP; SAP domain

  2. NM_153049.3 → NP_694629.2  myocardin-related transcription factor A isoform 1

    See identical proteins and their annotated locations for NP_694629.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AF532597, BC050941, BY208699
    Consensus CDS
    CCDS37147.1
    UniProtKB/Swiss-Prot
    Q642U1, Q8K4J6
    UniProtKB/TrEMBL
    Q3U1I6
    Related
    ENSMUSP00000105207.3, ENSMUST00000109579.9
    Conserved Domains (2) summary
    smart00707
    Location:103 → 128
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:385 → 418
    SAP; SAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80896482..81074937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4J6.2 GenPept UniProtKB/Swiss-Prot:Q8K4J6

Gene LinkOut

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