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Trpv2 transient receptor potential cation channel, subfamily V, member 2 [ Mus musculus (house mouse) ]

Gene ID: 22368, updated on 11-Apr-2024

Summary

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Official Symbol
Trpv2provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily V, member 2provided by MGI
Primary source
MGI:MGI:1341836
See related
Ensembl:ENSMUSG00000018507 AllianceGenome:MGI:1341836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRC; Vrl1; VRL-1; OTRPC2
Summary
Enables calcium channel activity. Involved in positive regulation of axon extension; positive regulation of calcium ion import; and positive regulation of cold-induced thermogenesis. Located in cell body; cell surface; and growth cone. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and testis. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 24.2), placenta adult (RPKM 13.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 38.48 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62465312..62491131)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62574486..62600305)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12279 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene ubiquitin B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62387853-62388036 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene STARR-positive B cell enhancer ABC_E9364 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus. Liu G, et al. Biochem Biophys Res Commun, 2022 Sep 10. PMID 35785569
  2. Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models. Iwata Y, et al. Lab Invest, 2020 Feb. PMID 31896817
  3. Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane. Maksoud MJE, et al. Glia, 2019 Dec. PMID 31453646
  4. Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity. Masubuchi H, et al. BMC Pulm Med, 2019 Mar 26. PMID 30914062, Free PMC Article
  5. TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells. Sawatani T, et al. Am J Physiol Cell Physiol, 2019 Mar 1. PMID 30649920

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ion channel TRPV2 is critical in enhancing B cell activation and function.
    Title: Ion channel TRPV2 is critical in enhancing B cell activation and function.
  2. High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
    Title: High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
  3. Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
    Title: Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
  4. Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
    Title: Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
  5. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells.
    Title: The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells.
  6. Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
    Title: Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
  7. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
    Title: Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
  8. Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
    Title: Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
  9. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.
    Title: TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.
  10. Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
    Title: Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to temperature stimulus ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
transient receptor potential cation channel subfamily V member 2
Names
growth factor regulated channel
growth factor-regulated calcium channel
osm-9-like TRP channel 2
vanilloid receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382489.1 → NP_001369418.1  transient receptor potential cation channel subfamily V member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596181
    UniProtKB/Swiss-Prot
    Q99K71, Q9WTR1
    Conserved Domains (2) summary
    sd00045
    Location:158 → 189
    ANK; ANK repeat [structural motif]
    cd22197
    Location:66 → 705
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

  2. NM_001382490.1 → NP_001369419.1  transient receptor potential cation channel subfamily V member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596181
    UniProtKB/Swiss-Prot
    Q99K71, Q9WTR1
    Conserved Domains (2) summary
    sd00045
    Location:158 → 189
    ANK; ANK repeat [structural motif]
    cd22197
    Location:66 → 705
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

  3. NM_001382491.1 → NP_001369420.1  transient receptor potential cation channel subfamily V member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596181
    Conserved Domains (2) summary
    sd00045
    Location:158 → 189
    ANK; ANK repeat [structural motif]
    cl40437
    Location:66 → 658
    TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)

  4. NM_001382492.1 → NP_001369421.1  transient receptor potential cation channel subfamily V member 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596181
    Conserved Domains (2) summary
    sd00045
    Location:158 → 189
    ANK; ANK repeat [structural motif]
    cl40437
    Location:66 → 647
    TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)

  5. NM_011706.2 → NP_035836.2  transient receptor potential cation channel subfamily V member 2 isoform 1

    See identical proteins and their annotated locations for NP_035836.2

    Status: VALIDATED

    Source sequence(s)
    AK008689, BB631765, BY648241
    Consensus CDS
    CCDS24827.1
    UniProtKB/Swiss-Prot
    Q99K71, Q9WTR1
    Related
    ENSMUSP00000018651.8, ENSMUST00000018651.14
    Conserved Domains (2) summary
    sd00045
    Location:158 → 189
    ANK; ANK repeat [structural motif]
    cd22197
    Location:66 → 705
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62465312..62491131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156630.1 → XP_036012523.1  transient receptor potential cation channel subfamily V member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99K71, Q9WTR1
    Related
    ENSMUSP00000099703.2, ENSMUST00000102643.2
    Conserved Domains (2) summary
    sd00045
    Location:158 → 189
    ANK; ANK repeat [structural motif]
    cd22197
    Location:66 → 705
    TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTR1.2 GenPept UniProtKB/Swiss-Prot:Q9WTR1

Gene LinkOut

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