U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arhgap39 Rho GTPase activating protein 39 [ Mus musculus (house mouse) ]

Gene ID: 223666, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Arhgap39provided by MGI
Official Full Name
Rho GTPase activating protein 39provided by MGI
Primary source
MGI:MGI:107858
See related
Ensembl:ENSMUSG00000033697 AllianceGenome:MGI:107858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Porf-2; Kiaa1688; 9530053N22; D15Wsu169e
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in postsynapse organization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm and glutamatergic synapse. Is expressed in several structures, including central nervous system; ganglia; gut; nose; and skeletal musculature. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 13.3), colon adult (RPKM 12.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Arhgap39 in Genome Data Viewer
Location:
15 D3; 15 36.28 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76608183..76702366, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76723985..76818166, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7385 Neighboring gene RIKEN cDNA C030006K11 gene Neighboring gene RecQ protein-like 4 Neighboring gene leucine rich repeat containing 14 Neighboring gene leucine rich repeat containing 24 Neighboring gene STARR-positive B cell enhancer mm9_chr15:76600695-76600996 Neighboring gene predicted gene, 17271 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350 Neighboring gene zinc finger protein 251 Neighboring gene STARR-positive B cell enhancer ABC_E11593 Neighboring gene STARR-positive B cell enhancer ABC_E2442 Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The RhoGAP domain-containing protein, Porf-2, inhibits proliferation and enhances apoptosis in neural stem cells. Ma S, et al. Mol Cell Neurosci, 2011 Mar. PMID 21185940
  2. Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth. Huang GH, et al. Cell Mol Life Sci, 2018 Nov. PMID 29938386
  3. Important roles of Vilse in dendritic architecture and synaptic plasticity. Lee JY, et al. Sci Rep, 2017 Apr 3. PMID 28368047, Free PMC Article
  4. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Porf-2 is capable of binding to the EphB1 receptor, causing the outgrowth of axons to stop and retract upon EphB forward signal transduction within the axon growth cone.
    Title: Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth.
  2. Dendritic structures of CA1 pyramidal neurons were altered in Rho GTPase activating protein 39/Vilse homozygous knockout (Vilse(Delta/Delta) mice.
    Title: Important roles of Vilse in dendritic architecture and synaptic plasticity.
  3. Data suggest that preoptic regulatory factor-2 (Porf-2) may inhibit neural stem cell proliferation by enhancing p21 protein levels followed by G1 phase arrest.
    Title: The RhoGAP domain-containing protein, Porf-2, inhibits proliferation and enhances apoptosis in neural stem cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho GTPase-activating protein 39
Names
preoptic regulatory factor-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168288.2 → NP_001161760.2  rho GTPase-activating protein 39 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS49654.2
    UniProtKB/Swiss-Prot
    P59281, Q69ZD4, Q6P9R6
    Related
    ENSMUSP00000158945.2, ENSMUST00000239003.2
    Conserved Domains (2) summary
    cd04389
    Location:912 → 1097
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:759 → 900
    MyTH4; MyTH4 domain

  2. NM_001416281.1 → NP_001403210.1  rho GTPase-activating protein 39 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156550

  3. NM_001416282.1 → NP_001403211.1  rho GTPase-activating protein 39 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550
    UniProtKB/TrEMBL
    H7BX46

  4. NM_001416283.1 → NP_001403212.1  rho GTPase-activating protein 39 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550
    UniProtKB/TrEMBL
    H7BX46

  5. NM_198420.3 → NP_940812.3  rho GTPase-activating protein 39 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27592.3
    Related
    ENSMUSP00000158984.2, ENSMUST00000239134.2
    Conserved Domains (2) summary
    cd04389
    Location:881 → 1066
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:759 → 869
    MyTH4; MyTH4 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76608183..76702366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248493.2 → XP_030104353.1  rho GTPase-activating protein 39 isoform X1

    UniProtKB/TrEMBL
    G3X932
    Conserved Domains (2) summary
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain

  2. XM_030248494.2 → XP_030104354.1  rho GTPase-activating protein 39 isoform X2

    UniProtKB/TrEMBL
    H7BX46
    Conserved Domains (2) summary
    cd04389
    Location:883 → 1068
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 872
    MyTH4; MyTH4 domain

  3. XM_036159348.1 → XP_036015241.1  rho GTPase-activating protein 39 isoform X1

    UniProtKB/TrEMBL
    G3X932
    Conserved Domains (2) summary
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain

  4. XM_030248492.2 → XP_030104352.1  rho GTPase-activating protein 39 isoform X1

    UniProtKB/TrEMBL
    G3X932
    Conserved Domains (2) summary
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain

  5. XM_006520794.4 → XP_006520857.1  rho GTPase-activating protein 39 isoform X1

    See identical proteins and their annotated locations for XP_006520857.1

    UniProtKB/TrEMBL
    G3X932
    Conserved Domains (2) summary
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59281.2 GenPept UniProtKB/Swiss-Prot:P59281

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous