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Vps45 vacuolar protein sorting 45 [ Mus musculus (house mouse) ]

Gene ID: 22365, updated on 11-Apr-2024

Summary

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Official Symbol
Vps45provided by MGI
Official Full Name
vacuolar protein sorting 45provided by MGI
Primary source
MGI:MGI:891965
See related
Ensembl:ENSMUSG00000015747 AllianceGenome:MGI:891965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mVps45
Summary
Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within protein transport. Located in Golgi membrane and endosome membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 3.3), CNS E14 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vps45 in Genome Data Viewer
Location:
3 F2.1; 3 41.65 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95907144..95969715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95999832..96059661, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9054 Neighboring gene pleckstrin homology domain containing, family O member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95836233-95836533 Neighboring gene STARR-positive B cell enhancer ABC_E2674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95861936-95862045 Neighboring gene predicted gene, 54210 Neighboring gene STARR-positive B cell enhancer ABC_E6079 Neighboring gene predicted gene, 30044 Neighboring gene OTU domain containing 7B Neighboring gene STARR-positive B cell enhancer ABC_E4561

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45. Roccisana J, et al. Mol Biol Cell, 2013 Aug. PMID 23741049, Free PMC Article
  2. Genetic mapping of vacuolar protein sorting-45 (Vps45) on mouse chromosome 3. Mishra VS, et al. Mamm Genome, 1998 Jan. PMID 9434958
  3. Mammalian VPS45 orchestrates trafficking through the endosomal system. Frey L, et al. Blood, 2021 Apr 8. PMID 33512427
  4. Identification of a mammalian Golgi Sec1p-like protein, mVps45. Tellam JT, et al. J Biol Chem, 1997 Mar 7. PMID 9045632
  5. Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. Pevsner J, et al. Gene, 1996 Dec 12. PMID 8996080

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mammalian VPS45 orchestrates trafficking through the endosomal system.
    Title: Mammalian VPS45 orchestrates trafficking through the endosomal system.
  2. A crucial role for mVps45 in the delivery of GLUT4 into its specialized, insulin-regulated compartment.
    Title: Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 45
Names
vacuolar protein sorting protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013841.3 → NP_038869.1  vacuolar protein sorting-associated protein 45

    See identical proteins and their annotated locations for NP_038869.1

    Status: VALIDATED

    Source sequence(s)
    AC092855, BC058528
    Consensus CDS
    CCDS17628.1
    UniProtKB/Swiss-Prot
    P97390, Q91VK9
    UniProtKB/TrEMBL
    Q3THX4
    Related
    ENSMUSP00000015891.6, ENSMUST00000015891.6
    Conserved Domains (1) summary
    pfam00995
    Location:23 → 539
    Sec1; Sec1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95907144..95969715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240074.3 → XP_011238376.1  vacuolar protein sorting-associated protein 45 isoform X1

    Conserved Domains (1) summary
    pfam00995
    Location:23 → 367
    Sec1; Sec1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97390.1 GenPept UniProtKB/Swiss-Prot:P97390

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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