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Ly6g2 lymphocyte antigen 6 family member G2 [ Mus musculus (house mouse) ]

Gene ID: 223631, updated on 8-Feb-2024

Summary

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Official Symbol
Ly6g2provided by MGI
Official Full Name
lymphocyte antigen 6 family member G2provided by MGI
Primary source
MGI:MGI:2385015
See related
Ensembl:ENSMUSG00000047728 AllianceGenome:MGI:2385015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in midgut; renal calyx; and renal pelvis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 47.5), large intestine adult (RPKM 18.3) and 6 other tissues See more
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Genomic context

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Location:
15 D3; 15 34.29 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75088227..75094510)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75216351..75222661)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G Neighboring gene predicted gene 28117 Neighboring gene predicted pseudogene 10238 Neighboring gene lymphocyte antigen 6 family member F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC29251

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6 complex, locus G2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371105.1 → NP_001358034.1  lymphocyte antigen 6 complex, locus G2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    Consensus CDS
    CCDS88780.1
    UniProtKB/TrEMBL
    A0A087WQT1
    Related
    ENSMUSP00000140330.2, ENSMUST00000185307.7
    Conserved Domains (1) summary
    cd00117
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  2. NM_001371106.1 → NP_001358035.1  lymphocyte antigen 6 complex, locus G2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    Consensus CDS
    CCDS88780.1
    UniProtKB/TrEMBL
    A0A087WQT1
    Conserved Domains (1) summary
    cd00117
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  3. NM_001371107.1 → NP_001358036.1  lymphocyte antigen 6 complex, locus G2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    Consensus CDS
    CCDS88780.1
    UniProtKB/TrEMBL
    A0A087WQT1
    Related
    ENSMUSP00000155184.2, ENSMUST00000229521.2
    Conserved Domains (1) summary
    cd00117
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  4. NM_001371108.1 → NP_001358037.1  lymphocyte antigen 6 complex, locus G2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    Consensus CDS
    CCDS88779.1
    UniProtKB/TrEMBL
    Q8R155
    Related
    ENSMUSP00000053396.7, ENSMUST00000055719.8
    Conserved Domains (1) summary
    cd00117
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  5. NM_001416438.1 → NP_001403367.1  lymphocyte antigen 6 complex, locus G2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    UniProtKB/TrEMBL
    Q8R155

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75088227..75094510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248479.1 → XP_030104339.1  lymphocyte antigen 6 complex, locus G2 isoform X1

    UniProtKB/TrEMBL
    A0A087WQT1
    Conserved Domains (1) summary
    cd00117
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_146058.1: Suppressed sequence

    Description
    NM_146058.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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