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Kcnk9 potassium channel, subfamily K, member 9 [ Mus musculus (house mouse) ]

Gene ID: 223604, updated on 11-Apr-2024

Summary

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Official Symbol
Kcnk9provided by MGI
Official Full Name
potassium channel, subfamily K, member 9provided by MGI
Primary source
MGI:MGI:3521816
See related
Ensembl:ENSMUSG00000036760 AllianceGenome:MGI:3521816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Task3; A930009L07Rik
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 23.2), cortex adult (RPKM 9.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnk9 in Genome Data Viewer
Location:
15; 15 D3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (72373722..72422415, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (72501873..72548614, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52221 Neighboring gene predicted gene, 24390 Neighboring gene STARR-positive B cell enhancer ABC_E8594 Neighboring gene STARR-seq mESC enhancer starr_38933 Neighboring gene STARR-seq mESC enhancer starr_38934 Neighboring gene trafficking protein particle complex 9 Neighboring gene predicted gene, 28020 Neighboring gene predicted gene, 53896 Neighboring gene paternally expressed 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina. Wen X, et al. Sci Adv, 2022 Sep 9. PMID 36070380, Free PMC Article
  2. Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis. Pfeuffer S, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35973573, Free PMC Article
  3. A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation. Maltby CJ, et al. Nucleic Acids Res, 2020 Sep 25. PMID 32870280, Free PMC Article
  4. Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Cooper A, et al. Nat Commun, 2020 Jan 24. PMID 31980599, Free PMC Article
  5. Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models. Liao P, et al. Sci Transl Med, 2019 Nov 20. PMID 31748231

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
    Title: TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
  2. Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
    Title: Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
  3. Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
    Title: Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
  4. Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
    Title: Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
  5. A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
    Title: A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
  6. Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
    Title: Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
  7. TASK-1 and TASK-3 strongly affect the development of pressure overload cardiomyopathies in genetic models of TASK-1 and TASK-3 loss of function.
    Title: TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
  8. Mutations in the actively expressed, maternal allele of the imprinted KCNK9 gene cause Birk-Barel intellectual disability syndrome (BBIDS). Using a BBIDS mouse model, we identify here a partial rescue of the BBIDS-like behavioral and neuronal phenotypes mediated via residual expression from the paternal Kcnk9 (Kcnk9(pat)) allele.
    Title: Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
  9. deleted TASK-1 and TASK-3 channels selectively from zona glomerulosa cells and generated a model of mild aldosterone autonomy with attendant hypertension that is aldosterone-driven and Ang II (angiotensin II)-independent.
    Title: Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.
  10. TASK3 potassium channel knockdown in monoamine neurons induces antidepressant-like responses in mice.
    Title: Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium channel subfamily K member 9
Names
TWIK-related acid-sensitive K(+) channel 3
acid-sensitive potassium channel protein TASK-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033876.2 → NP_001029048.1  potassium channel subfamily K member 9 precursor

    See identical proteins and their annotated locations for NP_001029048.1

    Status: VALIDATED

    Source sequence(s)
    AC118008, AC161195
    Consensus CDS
    CCDS27515.1
    UniProtKB/Swiss-Prot
    B2RT82, Q3LS21
    Related
    ENSMUSP00000038729.7, ENSMUST00000044624.8
    Conserved Domains (1) summary
    pfam07885
    Location:77 → 132
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    72373722..72422415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520768.5 → XP_006520831.1  potassium channel subfamily K member 9 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:279 → 334
    Ion_trans_2; Ion channel

  2. XM_036159328.1 → XP_036015221.1  potassium channel subfamily K member 9 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:279 → 334
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3LS21.1 GenPept UniProtKB/Swiss-Prot:Q3LS21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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