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Cyrib CYFIP related Rac1 interactor B [ Mus musculus (house mouse) ]

Gene ID: 223601, updated on 21-Apr-2024

Summary

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Official Symbol
Cyribprovided by MGI
Official Full Name
CYFIP related Rac1 interactor Bprovided by MGI
Primary source
MGI:MGI:1923520
See related
Ensembl:ENSMUSG00000022378 AllianceGenome:MGI:1923520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam49b; 0910001A06Rik
Summary
Enables MHC class Ib protein binding, via antigen binding activity groove. Involved in several processes, including positive regulation of T cell mediated cytotoxicity; positive regulation of interferon-gamma production; and positive regulation of memory T cell activation. Located in cilium. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 24.7), cerebellum adult (RPKM 18.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 28.16 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63800943..63932627, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63929094..64060778, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C4 Neighboring gene gasdermin C-like, pseudogene Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene STARR-seq mESC enhancer starr_38849 Neighboring gene predicted gene, 25628 Neighboring gene STARR-positive B cell enhancer ABC_E10857 Neighboring gene STARR-positive B cell enhancer ABC_E9912 Neighboring gene STARR-positive B cell enhancer ABC_E1906 Neighboring gene predicted gene 20717 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain1 Neighboring gene STARR-seq mESC enhancer starr_38853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:64017486-64017639 Neighboring gene STARR-seq mESC enhancer starr_38854 Neighboring gene VISTA enhancer mm1716 Neighboring gene STARR-seq mESC enhancer starr_38855 Neighboring gene RIKEN cDNA 1700010G06 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner. Huang Z, et al. Mol Immunol, 2022 Mar. PMID 35131594
  2. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Chattaragada MS, et al. Oncogene, 2018 Feb 8. PMID 29059164, Free PMC Article
  3. CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Yuki KE, et al. Nat Microbiol, 2019 Sep. PMID 31285585
  4. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nagarajan NA, et al. Nat Immunol, 2012 Apr 22. PMID 22522492, Free PMC Article
  5. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
    Title: Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
  2. FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.
    Title: FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class Ib protein binding, via antigen binding groove IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to molecule of bacterial origin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of memory T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CYFIP-related Rac1 interactor B
Names
family with sequence similarity 49, member B
protein FAM49B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360035.1 → NP_001346964.1  CYFIP-related Rac1 interactor B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1. 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC140673, AC156573
    Consensus CDS
    CCDS27505.1
    UniProtKB/Swiss-Prot
    Q921M7
    Related
    ENSMUSP00000132486.2, ENSMUST00000164532.3
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  2. NM_001360036.1 → NP_001346965.1  CYFIP-related Rac1 interactor B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC140673, AC156573
    Consensus CDS
    CCDS27505.1
    UniProtKB/Swiss-Prot
    Q921M7
    Related
    ENSMUSP00000154320.2, ENSMUST00000228226.2
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  3. NM_001360037.1 → NP_001346966.1  CYFIP-related Rac1 interactor B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.z
    Source sequence(s)
    AC140673, AC156573
    Consensus CDS
    CCDS27505.1
    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  4. NM_001360038.1 → NP_001346967.1  CYFIP-related Rac1 interactor B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a alternate AUG and result in an isoform (2) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140673, AC156573
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  5. NM_144846.5 → NP_659095.1  CYFIP-related Rac1 interactor B isoform 1

    See identical proteins and their annotated locations for NP_659095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK028062, BX527479, CK633763
    Consensus CDS
    CCDS27505.1
    UniProtKB/Swiss-Prot
    Q921M7
    Related
    ENSMUSP00000066359.5, ENSMUST00000063838.11
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63800943..63932627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248469.1 → XP_030104329.1  CYFIP-related Rac1 interactor B isoform X2

    Conserved Domains (2) summary
    PRK12323
    Location:1 → 91
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07159
    Location:109 → 404
    DUF1394; Protein of unknown function (DUF1394)

  2. XM_030248468.1 → XP_030104328.1  CYFIP-related Rac1 interactor B isoform X1

    Conserved Domains (2) summary
    PRK12323
    Location:1 → 129
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07159
    Location:121 → 417
    DUF1394; Protein of unknown function (DUF1394)

  3. XM_030248475.1 → XP_030104335.1  CYFIP-related Rac1 interactor B isoform X4

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  4. XM_030248470.2 → XP_030104330.1  CYFIP-related Rac1 interactor B isoform X3

    Conserved Domains (2) summary
    PRK12323
    Location:1 → 108
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07159
    Location:104 → 400
    DUF1394; Protein of unknown function (DUF1394)

  5. XM_030248471.2 → XP_030104331.1  CYFIP-related Rac1 interactor B isoform X4

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  6. XM_030248472.1 → XP_030104332.1  CYFIP-related Rac1 interactor B isoform X4

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  7. XM_036159327.1 → XP_036015220.1  CYFIP-related Rac1 interactor B isoform X5

    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  8. XM_036159326.1 → XP_036015219.1  CYFIP-related Rac1 interactor B isoform X4

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  9. XM_030248477.2 → XP_030104337.1  CYFIP-related Rac1 interactor B isoform X5

    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  10. XM_030248474.2 → XP_030104334.1  CYFIP-related Rac1 interactor B isoform X4

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  11. XM_030248476.2 → XP_030104336.1  CYFIP-related Rac1 interactor B isoform X5

    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  12. XM_011245564.3 → XP_011243866.1  CYFIP-related Rac1 interactor B isoform X5

    See identical proteins and their annotated locations for XP_011243866.1

    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  13. XM_006520763.4 → XP_006520826.1  CYFIP-related Rac1 interactor B isoform X4

    See identical proteins and their annotated locations for XP_006520826.1

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  14. XM_030248478.1 → XP_030104338.1  CYFIP-related Rac1 interactor B isoform X6

    Conserved Domains (1) summary
    pfam07159
    Location:1 → 174
    DUF1394; Protein of unknown function (DUF1394)

  15. XM_006520764.5 → XP_006520827.1  CYFIP-related Rac1 interactor B isoform X4

    See identical proteins and their annotated locations for XP_006520827.1

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  16. XM_006520766.3 → XP_006520829.1  CYFIP-related Rac1 interactor B isoform X6

    See identical proteins and their annotated locations for XP_006520829.1

    Conserved Domains (1) summary
    pfam07159
    Location:1 → 174
    DUF1394; Protein of unknown function (DUF1394)

  17. XM_006520762.5 → XP_006520825.1  CYFIP-related Rac1 interactor B isoform X5

    See identical proteins and their annotated locations for XP_006520825.1

    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  18. XM_030248473.2 → XP_030104333.1  CYFIP-related Rac1 interactor B isoform X4

    UniProtKB/Swiss-Prot
    Q921M7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  19. XM_006520765.3 → XP_006520828.1  CYFIP-related Rac1 interactor B isoform X5

    See identical proteins and their annotated locations for XP_006520828.1

    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921M7.1 GenPept UniProtKB/Swiss-Prot:Q921M7

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