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Nrsn1 neurensin 1 [ Mus musculus (house mouse) ]

Gene ID: 22360, updated on 11-Apr-2024

Summary

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Official Symbol
Nrsn1provided by MGI
Official Full Name
neurensin 1provided by MGI
Primary source
MGI:MGI:894662
See related
Ensembl:ENSMUSG00000048978 AllianceGenome:MGI:894662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vmp; Neuro-p24; Neurensin-1
Summary
Acts upstream of or within nervous system development. Located in cytoplasmic vesicle; growth cone; and neuronal cell body. Is expressed in several structures, including adrenal gland; eye; gonad; gut; and nervous system. Orthologous to human NRSN1 (neurensin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 110.6), frontal lobe adult (RPKM 100.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.1; 13 11.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25436022..25453979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (25252039..25269996, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene MRS2 magnesium transporter Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene doublecortin domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene STARR-seq mESC enhancer starr_33994 Neighboring gene predicted gene, 34122 Neighboring gene triosephosphate isomerase related sequence 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulatory expression of Neurensin-1 in the spinal motor neurons after mouse sciatic nerve injury. Suzuki H, et al. Neurosci Lett, 2007 Jun 27. PMID 17566649
  2. Neurensin-1 expression in the mouse retina during postnatal development and in the cultured retinal neurons. Nagata K, et al. Brain Res, 2006 Apr 7. PMID 16696124
  3. Multiple repressive mechanisms in the hippocampus during memory formation. Cho J, et al. Science, 2015 Oct 2. PMID 26430118
  4. Developmentally regulated expression of Neuro-p24 and its possible function in neurite extension. Araki M, et al. Neurosci Res, 2002 Dec. PMID 12445626
  5. A newly identified membrane protein localized exclusively in intracellular organelles of neurons. Kadota Y, et al. Brain Res Mol Brain Res, 1997 Jun. PMID 9191101

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation.
    Title: Multiple repressive mechanisms in the hippocampus during memory formation.
  2. The results of this study indicate that Nrsn1 plays an active role in axonal regeneration as well as in embryonic development.
    Title: Regulatory expression of Neurensin-1 in the spinal motor neurons after mouse sciatic nerve injury.
  3. Neurensin-2 was expressed in small vesicles including lysosomes in the perinuclear region. And was found in cell bodies.
    Title: Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells.
  4. Neurensin-1 plays a role in the fiber extension of the retinal neurons, and indicate that the developing retina is a suitable experimental model for the analysis of Neurensin function, both in vivo and in vitro.
    Title: Neurensin-1 expression in the mouse retina during postnatal development and in the cultured retinal neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neurensin-1
Names
vesicular membrane protein of 24 kDa
vesicular membrane protein p24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426601.1 → NP_001413530.1  neurensin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589766
    UniProtKB/Swiss-Prot
    P97799

  2. NM_001426602.1 → NP_001413531.1  neurensin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589766
    UniProtKB/Swiss-Prot
    P97799

  3. NM_001426603.1 → NP_001413532.1  neurensin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589766
    UniProtKB/Swiss-Prot
    P97799

  4. NM_001426604.1 → NP_001413533.1  neurensin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL589766
    UniProtKB/Swiss-Prot
    P97799

  5. NM_001426605.1 → NP_001413534.1  neurensin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589766

  6. NM_009513.2 → NP_033539.1  neurensin-1 isoform 1

    See identical proteins and their annotated locations for NP_033539.1

    Status: VALIDATED

    Source sequence(s)
    AU080650, BC052019
    Consensus CDS
    CCDS26387.1
    UniProtKB/Swiss-Prot
    P97799
    Related
    ENSMUSP00000055048.7, ENSMUST00000057866.13
    Conserved Domains (1) summary
    pfam14927
    Location:24 → 154
    Neurensin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    25436022..25453979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315503.2 → XP_017170992.1  neurensin-1 isoform X1

    UniProtKB/Swiss-Prot
    P97799
    Conserved Domains (1) summary
    pfam14927
    Location:24 → 154
    Neurensin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97799.1 GenPept UniProtKB/Swiss-Prot:P97799

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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