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Vill villin-like [ Mus musculus (house mouse) ]

Gene ID: 22351, updated on 11-Apr-2024

Summary

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Official Symbol
Villprovided by MGI
Official Full Name
villin-likeprovided by MGI
Primary source
MGI:MGI:1201781
See related
Ensembl:ENSMUSG00000038775 AllianceGenome:MGI:1201781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Villp
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Orthologous to human VILL (villin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 30.1), kidney adult (RPKM 10.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 71.32 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118881797..118900593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119052729..119071525)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase like Neighboring gene predicted gene, 33645 Neighboring gene microRNA 26a-1 Neighboring gene STARR-positive B cell enhancer ABC_E9778 Neighboring gene predicted gene, 51697 Neighboring gene phospholipase C, delta 1 Neighboring gene STARR-positive B cell enhancer ABC_E9779 Neighboring gene deleted in lung and esophageal cancer 1 Neighboring gene acetyl-Coenzyme A acyltransferase 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. Rieder G, et al. J Biol Chem, 2005 Feb 11. PMID 15576363
  2. E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Fu X, et al. Mol Cell Biol, 1997 Mar. PMID 9032278, Free PMC Article
  3. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
  4. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
  5. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin
    Title: Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
villin-like protein
Names
EF-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164567.1 → NP_001158039.1  villin-like protein isoform 1

    See identical proteins and their annotated locations for NP_001158039.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK028229, AK166823, BQ833192, CF171710, CN670511
    Consensus CDS
    CCDS52962.1
    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    UniProtKB/TrEMBL
    G5E8C6
    Related
    ENSMUSP00000061731.7, ENSMUST00000051386.13
    Conserved Domains (7) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611 → 707
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl02491
    Location:824 → 844
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. NM_011700.2 → NP_035830.2  villin-like protein isoform 2

    See identical proteins and their annotated locations for NP_035830.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when compared to isoform 1.
    Source sequence(s)
    AK028229, AK166652, AK166823, BB611096, CN670511
    Consensus CDS
    CCDS23606.1
    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    UniProtKB/TrEMBL
    G5E8H0
    Related
    ENSMUSP00000074294.7, ENSMUST00000074734.13
    Conserved Domains (6) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl02491
    Location:740 → 760
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118881797..118900593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512061.2 → XP_006512124.1  villin-like protein isoform X2

    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    Conserved Domains (7) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:808 → 828
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. XM_006512062.2 → XP_006512125.1  villin-like protein isoform X3

    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    Conserved Domains (7) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611 → 707
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:802 → 822
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  3. XM_006512059.4 → XP_006512122.1  villin-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512122.1

    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    Conserved Domains (7) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:830 → 850
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  4. XM_006512063.4 → XP_006512126.1  villin-like protein isoform X4

    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    Conserved Domains (6) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:762 → 782
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  5. XM_006512060.4 → XP_006512123.1  villin-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512123.1

    UniProtKB/Swiss-Prot
    P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6
    Conserved Domains (7) summary
    cd11288
    Location:508 → 596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 229
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 345
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385 → 485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:830 → 850
    VHP; Villin headpiece domain
    cl15697
    Location:16 → 121
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  6. XM_006512067.3 → XP_006512130.1  villin-like protein isoform X7

    UniProtKB/TrEMBL
    D3Z669
    Related
    ENSMUSP00000116262.2, ENSMUST00000126251.8
    Conserved Domains (4) summary
    cd11288
    Location:116 → 204
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:219 → 321
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:2 → 93
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:438 → 458
    VHP; Villin headpiece domain

  7. XM_006512065.3 → XP_006512128.1  villin-like protein isoform X5

    UniProtKB/TrEMBL
    D3Z669
    Related
    ENSMUSP00000116546.2, ENSMUST00000141185.8
    Conserved Domains (4) summary
    cd11288
    Location:124 → 212
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:227 → 329
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1 → 101
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:446 → 466
    VHP; Villin headpiece domain

  8. XM_006512066.5 → XP_006512129.1  villin-like protein isoform X6

    UniProtKB/TrEMBL
    D3Z669
    Conserved Domains (4) summary
    cd11288
    Location:124 → 212
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:227 → 329
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:7 → 101
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:446 → 466
    VHP; Villin headpiece domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YD6.1 GenPept UniProtKB/Swiss-Prot:Q91YD6

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