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Dcaf13 DDB1 and CUL4 associated factor 13 [ Mus musculus (house mouse) ]

Gene ID: 223499, updated on 21-Apr-2024

Summary

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Official Symbol
Dcaf13provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 13provided by MGI
Primary source
MGI:MGI:2684929
See related
Ensembl:ENSMUSG00000022300 AllianceGenome:MGI:2684929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm83; Wdsof1
Summary
Predicted to enable estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within rRNA processing. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex and small-subunit processome. Predicted to be active in nucleolus. Orthologous to human DCAF13 (DDB1 and CUL4 associated factor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 20.4), CNS E11.5 (RPKM 18.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 15.42 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38976300..39010251)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39112874..39146856)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38472 Neighboring gene STARR-positive B cell enhancer mm9_chr15:38944202-38944502 Neighboring gene solute carrier family 25, member 32 Neighboring gene collagen triple helix repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_38473 Neighboring gene STARR-seq mESC enhancer starr_38474 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38478 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene STARR-seq mESC enhancer starr_38479 Neighboring gene STARR-seq mESC enhancer starr_38480 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization. Yan X, et al. Mol Cell Endocrinol, 2022 Oct 1. PMID 35932979
  2. DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression. Shan BQ, et al. Cancer Sci, 2022 May. PMID 35178836, Free PMC Article
  3. Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing. Zhang J, et al. Cell Death Differ, 2019 Jul. PMID 30283081, Free PMC Article
  4. The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. Zhang J, et al. Cell Mol Life Sci, 2020 Jun. PMID 31492966
  5. Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. Liu Y, et al. Sci Rep, 2019 Apr 18. PMID 31000741, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.
    Title: Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.
  2. The DCAF13-dependent PTEN degradation mechanism fits in as a missing link between CRL4 ubiquitin E3 ligase and PI3K pathway, both of which are crucial for translational activation during oocyte germinal vesicle -metaphase of meiosis II transition.
    Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.
  3. CRL4-DCAF13-mediated SUV39H1 degradation is an essential step for progressive genome reprogramming during preimplantation embryonic development.
    Title: DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC65348

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in decidualization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic programming in the zygotic pronuclei ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oocyte growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle assembly involved in female meiosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 13
Names
WD repeat and SOF domain-containing protein 1
WD repeats and SOF domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416064.1 → NP_001402993.1  DDB1- and CUL4-associated factor 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101886, AC164883

  2. NM_198606.3 → NP_941008.2  DDB1- and CUL4-associated factor 13 isoform 1

    See identical proteins and their annotated locations for NP_941008.2

    Status: VALIDATED

    Source sequence(s)
    AC101886, AC164883
    Consensus CDS
    CCDS37066.1
    UniProtKB/Swiss-Prot
    E9QPL0, Q6PAC3
    Related
    ENSMUSP00000022909.9, ENSMUST00000022909.10
    Conserved Domains (4) summary
    COG2319
    Location:1 → 360
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:59 → 353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04158
    Location:354 → 438
    Sof1; Sof1-like domain
    sd00039
    Location:70 → 107
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    38976300..39010251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PAC3.2 GenPept UniProtKB/Swiss-Prot:Q6PAC3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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