U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vil1 villin 1 [ Mus musculus (house mouse) ]

Gene ID: 22349, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Vil1provided by MGI
Official Full Name
villin 1provided by MGI
Primary source
MGI:MGI:98930
See related
Ensembl:ENSMUSG00000026175 AllianceGenome:MGI:98930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vil
Summary
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; intestinal D-glucose absorption; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including brush border; filopodium tip; and lamellipodium. Is expressed in several structures, including brain; egg cylinder; gut; metanephros; and reproductive system. Orthologous to human VIL1 (villin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 318.1), small intestine adult (RPKM 235.7) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 C3; 1 38.54 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74448543..74474719)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74409384..74435560)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene STARR-seq mESC enhancer starr_01337 Neighboring gene predicted gene, 53562 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene phospholipase C, delta 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis. Wang Y, et al. Sci Rep, 2016 Oct 21. PMID 27765954, Free PMC Article
  2. Competition between tryptophan fluorescence and electron transfer during unfolding of the villin headpiece. Parson WW. Biochemistry, 2014 Jul 22. PMID 24972184
  3. Villin: A marker for development of the epithelial pyloric border. Braunstein EM, et al. Dev Dyn, 2002 May. PMID 11984877
  4. In vivo absorption of water and electrolytes in mouse intestine. Application to villin -/- mice. Athman R, et al. Am J Physiol Gastrointest Liver Physiol, 2002 Apr. PMID 11897622
  5. In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. Ferrary E, et al. J Cell Biol, 1999 Aug 23. PMID 10459016, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse intestinal tuft cells express advillin but not villin.
    Title: Mouse intestinal tuft cells express advillin but not villin.
  2. Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin.
    Title: Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.
  3. This study also highlights the potential role of villin's pro-apoptotic function in the pathogenesis of inflammatory bowel disease, ischemia-reperfusion injury, enteroinvasive bacterial and parasitic infections.
    Title: Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis.
  4. Competition between tryptophan fluorescence and electron transfer during unfolding of the villin headpiece.
    Title: Competition between tryptophan fluorescence and electron transfer during unfolding of the villin headpiece.
  5. villin severs F-actin to ensure microvillus depolarization and enterocyte remodeling upon intestinal injury
    Title: Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin.
  6. Villin-Cre(+);Klf4(fl/fl) have greater susceptibility to chemical-induced gastric carcinogenesis and increased rates of gastric tumor progression than control mice.
    Title: Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.
  7. The data establish that meprins interact with and cleave villin and actin, and these cytoskeletal proteins are substrates for meprins.
    Title: Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion.
  8. Villin is an actin regulatory protein that organizes, integrates and regulates multiple epithelial cell functions.
    Title: Regulation of cell structure and function by actin-binding proteins: villin's perspective.
  9. Data show that villin, characteristic markers of brush borders, become abnormally distributed along these atypical basolateral membranes in gal3(-/-) mice.
    Title: Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo.
  10. different regulatory sequences of the villin gene regulate expression in the intestinal epithelium
    Title: Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC143974

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lysophosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing ISO
Inferred from Sequence Orthology
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic actin-based contraction involved in cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intestinal D-glucose absorption IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in microvillus assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lamellipodium morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lamellipodium morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of microvillus length IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in terminal web assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament bundle ISO
Inferred from Sequence Orthology
more info
  
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border TAS
Traceable Author Statement
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
villin-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009509.2 → NP_033535.2  villin-1

    See identical proteins and their annotated locations for NP_033535.2

    Status: VALIDATED

    Source sequence(s)
    AI663456, AK027908, BB871941, BY426484
    Consensus CDS
    CCDS15049.1
    UniProtKB/Swiss-Prot
    Q149B6, Q62468, Q91WH4
    UniProtKB/TrEMBL
    Q8CEJ4
    Related
    ENSMUSP00000027366.7, ENSMUST00000027366.13
    Conserved Domains (7) summary
    cd11288
    Location:513 → 603
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 121
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:619 → 715
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:250 → 348
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:392 → 492
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:793 → 827
    VHP; Villin headpiece domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74448543..74474719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62468.3 GenPept UniProtKB/Swiss-Prot:Q62468

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous