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Nipal2 NIPA-like domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 223473, updated on 11-Apr-2024

Summary

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Official Symbol
Nipal2provided by MGI
Official Full Name
NIPA-like domain containing 2provided by MGI
Primary source
MGI:MGI:1924488
See related
Ensembl:ENSMUSG00000038879 AllianceGenome:MGI:1924488
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npal2; 9330161F08Rik
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in stomach. Orthologous to human NIPAL2 (NIPA like domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 4.2), bladder adult (RPKM 2.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 14.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34572942..34679739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34572796..34679207, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_38330 Neighboring gene predicted gene, 22208 Neighboring gene RIKEN cDNA 4930413F20 gene Neighboring gene predicted gene, 53873 Neighboring gene predicted gene, 53874 Neighboring gene predicted gene, 32970 Neighboring gene predicted gene, 53875

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NIPA-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145469.5 → NP_663444.2  NIPA-like protein 2

    See identical proteins and their annotated locations for NP_663444.2

    Status: PROVISIONAL

    Source sequence(s)
    AC130713, AC152940
    Consensus CDS
    CCDS37058.1
    UniProtKB/Swiss-Prot
    Q8CC43, Q91WC7
    UniProtKB/TrEMBL
    A0A0R4J0G3
    Related
    ENSMUSP00000038922.8, ENSMUST00000040791.9
    Conserved Domains (1) summary
    cl23754
    Location:45 → 332
    EamA; EamA-like transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    34572942..34679739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520055.5 → XP_006520118.1  NIPA-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8CC43, Q91WC7
    Conserved Domains (1) summary
    cl23754
    Location:45 → 312
    EamA; EamA-like transporter family

  2. XM_006520056.5 → XP_006520119.1  NIPA-like protein 2 isoform X2

    Conserved Domains (1) summary
    cl23754
    Location:29 → 214
    EamA; EamA-like transporter family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WC7.1 GenPept UniProtKB/Swiss-Prot:Q91WC7

Gene LinkOut

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