U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vars1 valyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 22321, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Vars1provided by MGI
Official Full Name
valyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:90675
See related
Ensembl:ENSMUSG00000007029 AllianceGenome:MGI:90675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G7a; Bat6; Vars; Vars2; D17H6S56E
Summary
Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; cranium; genitourinary system; midbrain; and telencephalon. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 96.4), spleen adult (RPKM 86.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Vars1 in Genome Data Viewer
Location:
17 B1; 17 18.54 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35219895..35235304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35000907..35016329)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene DNA segment, Chr 17, human D6S56E 5 Neighboring gene STARR-positive B cell enhancer ABC_E1941 Neighboring gene STARR-positive B cell enhancer ABC_E7526 Neighboring gene von Willebrand factor A domain containing 7 Neighboring gene suppressor APC domain containing 1 Neighboring gene predicted gene, 52318 Neighboring gene mutS homolog 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Lanning D, et al. Immunogenetics, 1999 Jun. PMID 10380693
  2. The sequence and organization of the mouse valyl-tRNA synthetase gene G7a/Bat6 located in the MHC class III region. Snoek M, et al. Immunogenetics, 1999 May. PMID 10199925
  3. A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC. Bedian V, et al. Immunogenetics, 1997. PMID 9271633
  4. A novel gene, G7e, resembling a viral envelope gene, is located at the recombinational hot spot in the class III region of the mouse MHC. Snoek M, et al. Genomics, 1996 Nov 15. PMID 8954773
  5. Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs. Olavesen MG, et al. Immunogenetics, 1993. PMID 8428774

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables valine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables valine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in valyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
valine--tRNA ligase
Names
protein G7a
valRS
NP_001411919.1
NP_035820.3
XP_017172885.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424990.1 → NP_001411919.1  valine--tRNA ligase

    Status: VALIDATED

    Source sequence(s)
    AC087117
    UniProtKB/Swiss-Prot
    Q9QUN2, Q9Z1Q9
    UniProtKB/TrEMBL
    Q790I0

  2. NM_011690.4 → NP_035820.3  valine--tRNA ligase

    See identical proteins and their annotated locations for NP_035820.3

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Consensus CDS
    CCDS37593.1
    UniProtKB/Swiss-Prot
    Q9QUN2, Q9Z1Q9
    UniProtKB/TrEMBL
    Q3U3D3, Q790I0, Q7TPT7
    Related
    ENSMUSP00000084572.8, ENSMUST00000087315.14
    Conserved Domains (2) summary
    PTZ00419
    Location:281 → 1263
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    cl02776
    Location:92 → 213
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35219895..35235304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317396.2 → XP_017172885.1  valine--tRNA ligase isoform X2

    UniProtKB/TrEMBL
    Q3TII4
    Conserved Domains (1) summary
    PTZ00419
    Location:1 → 895
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1Q9.1 GenPept UniProtKB/Swiss-Prot:Q9Z1Q9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous