Uxt ubiquitously expressed prefoldin like chaperone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uxtprovided by MGI
Official Full Name: ubiquitously expressed prefoldin like chaperoneprovided by MGI
Primary source: MGI:MGI:1277988
See related: Ensembl:ENSMUSG00000001134 AllianceGenome:MGI:1277988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0910002B17Rik
Summary: Predicted to enable beta-tubulin binding activity; chromatin binding activity; and transcription corepressor activity. Predicted to be involved in centrosome cycle and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within apoptotic process. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be active in chromatin. Is expressed in several structures, including cerebellum; neural retina; and telencephalon. Orthologous to human UXT (ubiquitously expressed prefoldin like chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 6.6), kidney adult (RPKM 6.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.3; X 16.46 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (20818162..20828259, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (20951665..20962017, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.
Title: Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.
UXT in Sertoli cells is required for blood-testis barrier integritydagger.
Title: UXT in Sertoli cells is required for blood-testis barrier integrity†.
Our study has revealed the first in vivo function for UXT in the mammalian germline as a regulator of distinct transcriptional programs in SSCs and differentiating spermatogonia.
Title: UXT is required for spermatogenesis in mice.
UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
Title: UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction.
Title: UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway.
Title: Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation.
Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
Uxt is a novel and essential cofactor in the NF-kappa B transcriptional enhanceosome.
Title: UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RPAP3/R2TP/prefoldin-like complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: protein UXT

Names: ubiquitously expressed transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418335.1 → NP_001405264.1 protein UXT isoform 2

Status: VALIDATED

Source sequence(s)

AL671853
NM_001418336.1 → NP_001405265.1 protein UXT isoform 3

Status: VALIDATED

Source sequence(s)

AL671853

Related

ENSMUST00000142341.2
NM_001418337.1 → NP_001405266.1 protein UXT isoform 1

Status: VALIDATED

Source sequence(s)

AL671853

UniProtKB/Swiss-Prot

Q8CEJ2, Q9WTZ0
NM_001418338.1 → NP_001405267.1 protein UXT isoform 1

Status: VALIDATED

Source sequence(s)

AL671853

UniProtKB/Swiss-Prot

Q8CEJ2, Q9WTZ0
NM_013840.4 → NP_038868.2 protein UXT isoform 1

See identical proteins and their annotated locations for NP_038868.2

Status: VALIDATED

Source sequence(s)

AL671853

Consensus CDS

CCDS30049.1

UniProtKB/Swiss-Prot

Q8CEJ2, Q9WTZ0

Related

ENSMUSP00000115342.2, ENSMUST00000123836.2

Conserved Domains (1) summary

cd00584
Location:18 → 147

Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RNA

NR_184722.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL671853

Related

ENSMUST00000001162.10
NR_184723.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL671853
NR_184724.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL671853