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Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked [ Mus musculus (house mouse) ]

Gene ID: 22290, updated on 11-Apr-2024

Summary

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Official Symbol
Utyprovided by MGI
Official Full Name
ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedprovided by MGI
Primary source
MGI:MGI:894810
See related
Ensembl:ENSMUSG00000068457 AllianceGenome:MGI:894810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hydb; mKIAA4057
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone H3-methyl-lysine-36 demethylase activity. Acts upstream of or within several processes, including animal organ development; cardiac muscle cell contraction; and heterochromatin assembly. Part of protein-containing complex. Is expressed in several structures, including early conceptus; forelimb bud; genitourinary system; gut; and liver. Orthologous to human UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.8), CNS E14 (RPKM 1.7) and 18 other tissues See more
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Genomic context

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Location:
Y; Ypter
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1085187..1245787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1085187..1245773, complement)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Neighboring gene STARR-seq mESC enhancer starr_48297 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene STARR-seq mESC enhancer starr_48298 Neighboring gene DEAD box helicase 3, Y-linked Neighboring gene predicted gene 4017 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The male minor transplantation antigen preferentially activates recipient CD4+ T cells through the indirect presentation pathway in vivo. Chen Y, et al. J Immunol, 2003 Dec 15. PMID 14662851
  2. Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells. Deschepper CF. Sci Rep, 2020 Sep 10. PMID 32913328, Free PMC Article
  3. TALEN-mediated editing of the mouse Y chromosome. Wang H, et al. Nat Biotechnol, 2013 Jun. PMID 23666012, Free PMC Article
  4. Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. Xu J, et al. J Neurosci, 2008 Apr 23. PMID 18434530, Free PMC Article
  5. CD4 cells can be more efficient at tumor rejection than CD8 cells. Perez-Diez A, et al. Blood, 2007 Jun 15. PMID 17327412, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells.
    Title: Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells.
  2. Our data suggest that UTX and UTY are able to regulate gene activity through demethylase independent mechanisms
    Title: UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.
  3. UTX controls mesoderm differentiation and Brachyury expression independent of H3K27 demethylase activity; UTX and UTY are functionally redundant in ES cell differentiation and early embryonic development
    Title: UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
  4. Regional brain expression of the Y-linked paralogue Uty is distinct from that of Utx, specifically in the paraventricular nucleus of the hypothalamus (high Uty) and the amygdala (high Utx).
    Title: Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.
  5. Activation of T cell receptor-transgenic T cells preferentially occurs through cognate interactions with a peptide determinant derived from the HYDb male antigen, which is expressed on recipient antigen presenting cells after heart transplantation.
    Title: The male minor transplantation antigen preferentially activates recipient CD4+ T cells through the indirect presentation pathway in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • KIAA4057

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K27me2/H3K27me3 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone demethylase UTY
Names
[histone H3]-trimethyl-L-lysine(27) demethylase UTY
male-specific histocompatibility antigen H-YDB
ubiquitously transcribed TPR protein on the Y chromosome
ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
NP_001313611.1
NP_001313612.1
NP_001406755.1
NP_001406756.1
NP_001406757.1
NP_001406758.1
NP_001406759.1
NP_033510.2
XP_006531650.1
XP_011246883.1
XP_011246884.1
XP_011246885.1
XP_011246886.1
XP_011246887.1
XP_011246888.1
XP_011246891.1
XP_017174175.1
XP_017174176.1
XP_017174177.1
XP_017174178.1
XP_030107425.1
XP_036018083.1
XP_036018084.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326682.2 → NP_001313611.1  histone demethylase UTY isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319
    Consensus CDS
    CCDS85834.1
    UniProtKB/Swiss-Prot
    O97979, P79457
    UniProtKB/TrEMBL
    E9PWW8
    Related
    ENSMUSP00000114752.2, ENSMUST00000139365.8
    Conserved Domains (7) summary
    pfam02373
    Location:944 → 1052
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:910 → 974
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00006
    Location:279 → 306
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:124 → 157
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:311 → 372
    TPR_11; TPR repeat
    pfam13424
    Location:274 → 342
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:266 → 297
    TPR_17; Tetratricopeptide repeat

  2. NM_001326683.2 → NP_001313612.1  histone demethylase UTY isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319
    Consensus CDS
    CCDS85833.1
    UniProtKB/Swiss-Prot
    O97979, P79457
    UniProtKB/TrEMBL
    Q3UQE8
    Related
    ENSMUSP00000114910.2, ENSMUST00000154004.8
    Conserved Domains (7) summary
    pfam02373
    Location:882 → 990
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:848 → 912
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00006
    Location:217 → 244
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:62 → 95
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:249 → 310
    TPR_11; TPR repeat
    pfam13424
    Location:212 → 280
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:204 → 235
    TPR_17; Tetratricopeptide repeat

  3. NM_001419826.1 → NP_001406755.1  histone demethylase UTY isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319

  4. NM_001419827.1 → NP_001406756.1  histone demethylase UTY isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319

  5. NM_001419828.1 → NP_001406757.1  histone demethylase UTY isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319

  6. NM_001419829.1 → NP_001406758.1  histone demethylase UTY isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319

  7. NM_001419830.1 → NP_001406759.1  histone demethylase UTY isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319

  8. NM_009484.4 → NP_033510.2  histone demethylase UTY isoform 1

    See identical proteins and their annotated locations for NP_033510.2

    Status: VALIDATED

    Source sequence(s)
    AC145571, AC148319
    Consensus CDS
    CCDS41216.1
    UniProtKB/Swiss-Prot
    O97979, P79457
    UniProtKB/TrEMBL
    G3X9F2
    Related
    ENSMUSP00000070012.8, ENSMUST00000069309.14
    Conserved Domains (7) summary
    pfam02373
    Location:945 → 1053
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:911 → 975
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00006
    Location:280 → 307
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:125 → 158
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:312 → 373
    TPR_11; TPR repeat
    pfam13424
    Location:275 → 343
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:267 → 298
    TPR_17; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    1085187..1245787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248585.4 → XP_011246887.1  histone demethylase UTY isoform X9

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:935 → 999
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130 → 397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304 → 331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:969 → 1077
    JmjC; JmjC domain, hydroxylase

  2. XM_011248583.2 → XP_011246885.1  histone demethylase UTY isoform X5

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:916 → 980
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:111 → 378
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:950 → 1058
    JmjC; JmjC domain, hydroxylase

  3. XM_036162190.1 → XP_036018083.1  histone demethylase UTY isoform X13

    UniProtKB/TrEMBL
    E9Q504
    Conserved Domains (4) summary
    smart00558
    Location:862 → 926
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:97 → 369
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:276 → 303
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:896 → 1004
    JmjC; JmjC domain, hydroxylase

  4. XM_011248582.4 → XP_011246884.1  histone demethylase UTY isoform X4

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:931 → 995
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:126 → 393
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:300 → 327
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:965 → 1073
    JmjC; JmjC domain, hydroxylase

  5. XM_030251565.2 → XP_030107425.1  histone demethylase UTY isoform X15

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:848 → 912
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:38 → 310
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:217 → 244
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:882 → 990
    JmjC; JmjC domain, hydroxylase

  6. XM_011248581.4 → XP_011246883.1  histone demethylase UTY isoform X3

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:932 → 996
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:127 → 394
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:301 → 328
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:966 → 1074
    JmjC; JmjC domain, hydroxylase

  7. XM_017318687.3 → XP_017174176.1  histone demethylase UTY isoform X2

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:934 → 998
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:129 → 396
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:303 → 330
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:968 → 1076
    JmjC; JmjC domain, hydroxylase

  8. XM_017318688.3 → XP_017174177.1  histone demethylase UTY isoform X14

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:851 → 915
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:41 → 313
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:220 → 247
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:885 → 993
    JmjC; JmjC domain, hydroxylase

  9. XM_006531587.5 → XP_006531650.1  histone demethylase UTY isoform X18

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:886 → 950
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:101 → 373
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:280 → 307
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:920 → 1028
    JmjC; JmjC domain, hydroxylase

  10. XM_011248586.4 → XP_011246888.1  histone demethylase UTY isoform X10

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:890 → 954
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130 → 397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304 → 331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:924 → 1032
    JmjC; JmjC domain, hydroxylase

  11. XM_011248584.4 → XP_011246886.1  histone demethylase UTY isoform X6

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:910 → 974
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130 → 397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304 → 331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:944 → 1052
    JmjC; JmjC domain, hydroxylase

  12. XM_017318686.3 → XP_017174175.1  histone demethylase UTY isoform X1

    UniProtKB/Swiss-Prot
    O97979, P79457
    Conserved Domains (4) summary
    smart00558
    Location:935 → 999
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130 → 397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304 → 331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:969 → 1077
    JmjC; JmjC domain, hydroxylase

  13. XM_036162191.1 → XP_036018084.1  histone demethylase UTY isoform X17

    UniProtKB/TrEMBL
    Q3TNX2
    Conserved Domains (2) summary
    smart00558
    Location:448 → 512
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02373
    Location:482 → 590
    JmjC; JmjC domain, hydroxylase

  14. XM_017318689.2 → XP_017174178.1  histone demethylase UTY isoform X17

    UniProtKB/TrEMBL
    Q3TNX2
    Conserved Domains (2) summary
    smart00558
    Location:448 → 512
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02373
    Location:482 → 590
    JmjC; JmjC domain, hydroxylase

  15. XM_011248589.4 → XP_011246891.1  histone demethylase UTY isoform X16

    Conserved Domains (2) summary
    COG0457
    Location:130 → 397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304 → 331
    TPR; TPR repeat [structural motif]

RNA

  1. XR_004940595.1 RNA Sequence

  2. XR_879400.4 RNA Sequence

  3. XR_004940593.1 RNA Sequence

  4. XR_004940592.1 RNA Sequence

  5. XR_001782882.3 RNA Sequence

    Related
    ENSMUST00000154666.8

  6. XR_004940594.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79457.2 GenPept UniProtKB/Swiss-Prot:P79457

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