Usf2 upstream transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usf2provided by MGI
Official Full Name: upstream transcription factor 2provided by MGI
Primary source: MGI:MGI:99961
See related: Ensembl:ENSMUSG00000058239 AllianceGenome:MGI:99961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Usf-2; bHLHb12
Summary: Enables DNA binding activity. Involved in lipid homeostasis and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within lactation; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 66.5), ovary adult (RPKM 53.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.27 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30645421..30656288, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30945248..30956951, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence.
Title: A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence.
Knockdown of USF2 inhibits pyroptosis of podocytes and attenuates kidney injury in lupus nephritis.
Title: Knockdown of USF2 inhibits pyroptosis of podocytes and attenuates kidney injury in lupus nephritis.
WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
Title: WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.
Title: Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.
Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells.
Title: Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells.
AGTRAP expression is regulated by USF1 and USF2
Title: Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.
USF1 and USF2 are important regulatory factors for Alx3 gene expression in different cell types
Title: Differential configurations involving binding of USF transcription factors and Twist1 regulate Alx3 promoter activity in mesenchymal and pancreatic cells.
Data suggest that both USF1 and USF2 are essential for angiotensinogen (AGT) transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors.
Title: Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.
USF-1 but not USF-2 was strongly enriched at Dbeta2 in chromatin from either Rag2-/- double-negative thymocytes or Rag2-/- thymocytes that express a rearranged Tcrb transgene.
Title: DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.
USF2 promotes renal renin expression and stimulates angiotensin II generation, leading to activation of the intrarenal renin-angiotensin system.
Title: Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485014

PMC37512P1 (e-PCR)
- UniSTS:273306

U01663 (e-PCR)
- UniSTS:125639

Lsr (e-PCR), detects polymorphism
- UniSTS:498389

Usf2 (e-PCR), detects polymorphism
- UniSTS:527602

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: upstream stimulatory factor 2

Names: major late transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421807.1 → NP_001408736.1 upstream stimulatory factor 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC149055

UniProtKB/TrEMBL

F8WI12
NM_001421808.1 → NP_001408737.1 upstream stimulatory factor 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC149055
NM_001421809.1 → NP_001408738.1 upstream stimulatory factor 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC149055
NM_011680.3 → NP_035810.1 upstream stimulatory factor 2 isoform 1

See identical proteins and their annotated locations for NP_035810.1

Status: VALIDATED

Source sequence(s)

AC149055

Consensus CDS

CCDS21118.1

UniProtKB/Swiss-Prot

Q3UIL2, Q64705, Q8VE59

UniProtKB/TrEMBL

F6PWU6

Related

ENSMUSP00000132256.2, ENSMUST00000058860.14

Conserved Domains (2) summary

cd18923
Location:229 → 308

bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins

pfam06005
Location:290 → 334

ZapB; Cell division protein ZapB