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Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22273, updated on 21-Apr-2024

Summary

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Official Symbol
Uqcrc1provided by MGI
Official Full Name
ubiquinol-cytochrome c reductase core protein 1provided by MGI
Primary source
MGI:MGI:107876
See related
Ensembl:ENSMUSG00000025651 AllianceGenome:MGI:107876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110032G10Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 872.4), duodenum adult (RPKM 565.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F2; 9 59.63 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108765716..108778709)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108936648..108949641)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5104 Neighboring gene solute carrier family 26, member 6 Neighboring gene transmembrane protein 89 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108838602-108838711 Neighboring gene collagen, type VII, alpha 1 Neighboring gene microRNA 711 Neighboring gene urocortin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise. Yi T, et al. Exp Biol Med (Maywood), 2022 Jan. PMID 34648372, Free PMC Article
  2. Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer. Wang Q, et al. Theranostics, 2020. PMID 32089737, Free PMC Article
  3. Critical role of UQCRC1 in embryo survival, brain ischemic tolerance and normal cognition in mice. Shan W, et al. Cell Mol Life Sci, 2019 Apr. PMID 30666338, Free PMC Article
  4. Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Kriaucionis S, et al. Mol Cell Biol, 2006 Jul. PMID 16782889, Free PMC Article
  5. BCS1L is expressed in critical regions for neural development during ontogenesis in mice. Kotarsky H, et al. Gene Expr Patterns, 2007 Jan. PMID 17049929

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
    Title: Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
  2. Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
    Title: Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
  3. UQCRC1 is critical for the development and survival of embryos. UQCRC1 is also important for the proper function of the complex III, which may affect the brain ischemic tolerance and normal learning and memory.
    Title: Critical role of UQCRC1 in embryo survival, brain ischemic tolerance and normal cognition in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC97899

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mitochondrial electron transport, ubiquinol to cytochrome c IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome b-c1 complex subunit 1, mitochondrial
Names
complex III subunit 1
core protein I
ubiquinol-cytochrome-c reductase complex core protein 1
NP_079683.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025407.2 → NP_079683.2  cytochrome b-c1 complex subunit 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079683.2

    Status: VALIDATED

    Source sequence(s)
    AI462428, AK010553, BB649589, BY260300
    Consensus CDS
    CCDS23540.1
    UniProtKB/Swiss-Prot
    Q3TV75, Q9CWL6, Q9CZ13
    UniProtKB/TrEMBL
    Q3TIC8
    Related
    ENSMUSP00000026743.9, ENSMUST00000026743.14
    Conserved Domains (3) summary
    COG0612
    Location:46 → 469
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:58 → 205
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:210 → 395
    Peptidase_M16_C; Peptidase M16 inactive domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108765716..108778709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ13.2 GenPept UniProtKB/Swiss-Prot:Q9CZ13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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