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Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII [ Mus musculus (house mouse) ]

Gene ID: 22272, updated on 2-Apr-2024

Summary

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Official Symbol
Uqcrqprovided by MGI
Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit VIIprovided by MGI
Primary source
MGI:MGI:107807
See related
Ensembl:ENSMUSG00000044894 AllianceGenome:MGI:107807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qpc; QP-C; Uqcrb; c1502; 9.5kDa; 1100001F06Rik; 1500040F11Rik; 5830407L17Rik
Summary
Predicted to enable ubiquinol-cytochrome-c reductase activity. Acts upstream of or within brain development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 4. Orthologous to human UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 291.7), liver adult (RPKM 266.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53318749..53321658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53427922..53430831, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family, member 4 Neighboring gene microRNA 6920 Neighboring gene STARR-positive B cell enhancer ABC_E76 Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene growth differentiation factor 9 Neighboring gene predicted gene 10447

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Weinberg SE, et al. Nature, 2019 Jan. PMID 30626970, Free PMC Article
  2. Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis. Wculek SK, et al. Immunity, 2023 Mar 14. PMID 36738738
  3. Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly. Zhang S, et al. Nat Commun, 2020 Mar 11. PMID 32161263, Free PMC Article
  4. Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. Sadakata T, et al. Neurosci Lett, 2006 Sep 25. PMID 16901643
  5. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance. Ma W, et al. Sci Adv, 2021 Apr. PMID 33931446, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cerebellar Purkinje cell layer development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hypothalamus development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in midbrain development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in pons development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in pyramidal neuron development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in subthalamus development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in thalamus development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome b-c1 complex subunit 8
Names
complex III subunit 8
complex III subunit VII
complex III subunit VIII
low molecular mass ubiquinone-binding protein (Qpc-pending)
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase complex 9.5 kDa protein
ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
NP_001313543.1
NP_079628.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326614.1 → NP_001313543.1  cytochrome b-c1 complex subunit 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003160, AK005374, AL592489, CB950804
    Consensus CDS
    CCDS36151.1
    UniProtKB/Swiss-Prot
    Q9CQ69
    Related
    ENSMUSP00000104649.4, ENSMUST00000109021.4
    Conserved Domains (1) summary
    pfam02939
    Location:4 → 79
    UcrQ; UcrQ family

  2. NM_025352.3 → NP_079628.1  cytochrome b-c1 complex subunit 8

    See identical proteins and their annotated locations for NP_079628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein
    Source sequence(s)
    AK005374, AK007982, AL592489, CB950804
    Consensus CDS
    CCDS36151.1
    UniProtKB/Swiss-Prot
    Q9CQ69
    Related
    ENSMUSP00000053145.5, ENSMUST00000061326.5
    Conserved Domains (1) summary
    pfam02939
    Location:4 → 79
    UcrQ; UcrQ family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    53318749..53321658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ69.3 GenPept UniProtKB/Swiss-Prot:Q9CQ69

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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