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Upp1 uridine phosphorylase 1 [ Mus musculus (house mouse) ]

Gene ID: 22271, updated on 21-Apr-2024

Summary

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Official Symbol
Upp1provided by MGI
Official Full Name
uridine phosphorylase 1provided by MGI
Primary source
MGI:MGI:1097668
See related
Ensembl:ENSMUSG00000020407 AllianceGenome:MGI:1097668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Up; Upp; UPase; UdRPase
Summary
Enables deoxyuridine phosphorylase activity; thymidine phosphorylase activity; and uridine phosphorylase activity. Involved in pyrimidine nucleoside monophosphate metabolic process and uridine catabolic process. Acts upstream of or within pyrimidine nucleotide metabolic process and uridine metabolic process. Located in cytosol. Is expressed in early embryo; extraembryonic ectoderm; nervous system; and sensory organ. Orthologous to human UPP1 (uridine phosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 191.4), small intestine adult (RPKM 74.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 6.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (9068008..9086170)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (9118008..9136170)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene HUS1 checkpoint clamp component Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene predicted gene 11992 Neighboring gene STARR-seq mESC enhancer starr_28553 Neighboring gene STARR-seq mESC enhancer starr_28555 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C pseudogene Neighboring gene ATP-binding cassette, sub-family A member 13 Neighboring gene STARR-seq mESC enhancer starr_28556 Neighboring gene STARR-seq mESC enhancer starr_28557 Neighboring gene STARR-seq mESC enhancer starr_28558 Neighboring gene STARR-seq mESC enhancer starr_28559 Neighboring gene STARR-seq mESC enhancer starr_28560 Neighboring gene STARR-seq mESC enhancer starr_28561 Neighboring gene STARR-seq mESC enhancer starr_28562

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Uridine homeostatic disorder leads to DNA damage and tumorigenesis. Cao Z, et al. Cancer Lett, 2016 Mar 28. PMID 26801745
  2. Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity. Cao D, et al. Mol Cancer Ther, 2011 Dec. PMID 21954436, Free PMC Article
  3. SPECIFICITY OF MOUSE URIDINE PHOSPHORYLASE. CHROMATOGRAPHY, PURIFICATION, AND PROPERTIES. KRENITSKY TA, et al. J Biol Chem, 1964 Mar. PMID 14154460
  4. Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cao D, et al. Cancer Res, 2002 Apr 15. PMID 11956089
  5. Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. Cao D, et al. Cancer Res, 1999 Oct 1. PMID 10519414

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy.
    Title: Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity.
  2. Data show that enhanced cytotoxicity of 5-FU by bFGF through modulating the expression of UPP1 at the transcription level.
    Title: Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.
  3. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
    Title: Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.
  4. Taken together, the present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase.
    Title: Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase.
  5. UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity
    Title: Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.
  6. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.
    Title: Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyuridine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables thymidine phosphorylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thymidine phosphorylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine phosphorylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables uridine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dCMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in dTMP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dTMP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dUMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyrimidine nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uridine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uridine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uridine catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within uridine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uridine phosphorylase 1
Names
UPase 1
urdPase 1
NP_001152873.1
NP_001152874.1
NP_033503.2
XP_006514730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159401.1 → NP_001152873.1  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_001152873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK136474, AV447018, BX527866
    Consensus CDS
    CCDS24432.1
    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Related
    ENSMUSP00000099063.3, ENSMUST00000101525.9
    Conserved Domains (1) summary
    cd17763
    Location:32 → 306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  2. NM_001159402.1 → NP_001152874.1  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_001152874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK136474, BX527866, CA493594
    Consensus CDS
    CCDS24432.1
    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Related
    ENSMUSP00000127473.2, ENSMUST00000164791.8
    Conserved Domains (1) summary
    cd17763
    Location:32 → 306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  3. NM_009477.3 → NP_033503.2  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_033503.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK136474, AL118479, BX527866, CA536983
    Consensus CDS
    CCDS24432.1
    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Related
    ENSMUSP00000020677.2, ENSMUST00000020677.8
    Conserved Domains (1) summary
    cd17763
    Location:32 → 306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    9068008..9086170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514667.3 → XP_006514730.1  uridine phosphorylase 1 isoform X1

    See identical proteins and their annotated locations for XP_006514730.1

    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Conserved Domains (1) summary
    cd17763
    Location:32 → 306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52624.2 GenPept UniProtKB/Swiss-Prot:P52624

Gene LinkOut

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