Unc13b unc-13 homolog B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc13bprovided by MGI
Official Full Name: unc-13 homolog Bprovided by MGI
Primary source: MGI:MGI:1342278
See related: Ensembl:ENSMUSG00000028456 AllianceGenome:MGI:1342278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unc13a; Unc13h1; Unc13h2; Munc13-1; Munc13-2
Summary: Predicted to enable GTP-dependent protein binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Involved in several processes, including negative regulation of synaptic plasticity; positive regulation of defense response to bacterium; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; innervation; and regulation of short-term neuronal synaptic plasticity. Located in several cellular components, including calyx of Held; early phagosome; and glutamatergic synapse. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 6.9), CNS E14 (RPKM 6.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.0 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43046193..43264873)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43046193..43264873)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.
Title: Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.
Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking.
Title: Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking.
Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly.
Title: Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly.
Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.
Title: Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.
Here the authors show that that the C1C2BMUNC2C domain bridges membranes through opposite ends of its elongated structure. Mutations in putative membrane-binding sites lead to corresponding disruptive effects on synaptic vesicle docking, priming, and Ca(2+)-triggered neurotransmitter release in mouse neurons.
Title: Membrane bridging by Munc13-1 is crucial for neurotransmitter release.
At hippocampal mossy fiber synapses, RIM-BP2 has a substantial impact on neurotransmitter release by promoting vesicle docking/priming and vesicular release probability via stabilization of Munc13-1 at the active zone.
Title: RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.
Munc13-1 and Munc18-1, but not CAPS-1/2, stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.
Title: Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.
Data suggest that the Munc13-1/2 heterodimer is an active component of the vesicle docking, priming and release complex.
Title: Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming.
In a model of systemic anaphylaxis, we found no difference between WT and Munc13-2 KO mice, but global and mast cells-specific Munc13-4 KO mice developed less hypothermia. We conclude that although Munc13-2 plays a minor role, Munc13-4 is essential for regulated exocytosis in mast cells
Title: Munc13 proteins control regulated exocytosis in mast cells.
Mutating Ca(2+)-coordinating aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstream priming step Ca(2+)-independent, whereas a separate function in downstream priming depends on SNARE-binding, Ca(2+)-binding to the C2B-domain of Doc2B, interaction with ubMunc13-2 and the presence of synaptotagmin-1.
Title: Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit286 (e-PCR), detects polymorphism
- UniSTS:130077

NoName (e-PCR)
- UniSTS:234903

PMC30485P1 (e-PCR)
- UniSTS:272536

D4Mit182 (e-PCR), detects polymorphism
- UniSTS:129963

MARC_17336-17337:1021394418:1 (e-PCR)
- UniSTS:268276

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-kinase phorbol ester receptor activity	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in dense core granule docking	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dense core granule priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in dense core granule priming	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innervation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuronal dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in presynaptic dense core vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle docking	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IC Inferred by Curator more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein unc-13 homolog B

Names: UNC-13 homolog 1; munc13; unc13 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081413.2 → NP_001074882.1 protein unc-13 homolog B isoform 2

See identical proteins and their annotated locations for NP_001074882.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one amino acid shorter than isoform 1.

Source sequence(s)

AL672276, BB612447, BI202627, BP758729, BQ572350, BU613335, BY741509, CB245273, CB520764, CD351898, CJ053228, CK636958, CN459646, CO434486, CX568667, DV661336, EL605839

Consensus CDS

CCDS38738.1

UniProtKB/Swiss-Prot

Q9Z1N9

Related

ENSMUSP00000128608.2, ENSMUST00000163653.8

Conserved Domains (6) summary

cd04027
Location:612 → 738

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1449 → 1568

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:490 → 539

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:930 → 1032

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1275 → 1411

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
NM_001310758.1 → NP_001297687.1 protein unc-13 homolog B isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter and has a distinct amino acid at the splice variant junction compared to isoform 1.

Source sequence(s)

AL672276, BB612447, BI202627, BP758729, BQ572350, BU613335, BY741509, CB520764, CF746404, CJ053228, CK636958, CN459646, CO434486, CX568667, DV661336, EL605839

Consensus CDS

CCDS80089.1

UniProtKB/Swiss-Prot

Q9Z1N9

Related

ENSMUSP00000078894.7, ENSMUST00000079978.13

Conserved Domains (6) summary

cd04027
Location:600 → 726

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1438 → 1557

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:478 → 527

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:918 → 1021

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1264 → 1400

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
NM_001384106.1 → NP_001371035.1 protein unc-13 homolog B isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).

Source sequence(s)

AL672276, AL732504, AL772176

UniProtKB/TrEMBL

A0A140LJ69

Related

ENSMUSP00000147100.2, ENSMUST00000207569.2

Conserved Domains (6) summary

cd04027
Location:3295 → 3421

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:4133 → 4252

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:3613 → 3716

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:3959 → 4095

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:3154 → 3235

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
NM_021468.3 → NP_067443.2 protein unc-13 homolog B isoform 1

See identical proteins and their annotated locations for NP_067443.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL672276, BB612447, BI202627, BP758729, BQ572350, BU613335, BY741509, CB520764, CD351898, CJ053228, CK636958, CN459646, CO434486, CX568667, DV661336, EL605839

Consensus CDS

CCDS51161.1

UniProtKB/Swiss-Prot

A2AG43, B2RXT0, B2RXY6, Q6BCX2, Q9Z1N9

Related

ENSMUSP00000103586.3, ENSMUST00000107952.9

Conserved Domains (6) summary

cd04027
Location:612 → 738

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1450 → 1569

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:490 → 539

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:930 → 1033

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1276 → 1412

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

43046193..43264873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163977.1 → XP_036019870.1 protein unc-13 homolog B isoform X17

Conserved Domains (5) summary

cd04027
Location:520 → 646

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1377 → 1496

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:838 → 941

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1184 → 1320

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:379 → 460

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_036163971.1 → XP_036019864.1 protein unc-13 homolog B isoform X8

Conserved Domains (6) summary

cd04027
Location:625 → 751

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1482 → 1601

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:943 → 1046

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1289 → 1425

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:484 → 565

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_036163972.1 → XP_036019865.1 protein unc-13 homolog B isoform X9

Conserved Domains (6) summary

cd04027
Location:623 → 749

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1480 → 1599

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:941 → 1044

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1287 → 1423

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:482 → 563

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_036163975.1 → XP_036019868.1 protein unc-13 homolog B isoform X14

Conserved Domains (6) summary

cd04027
Location:623 → 749

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1461 → 1580

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:941 → 1044

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1287 → 1423

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:482 → 563

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_006537791.5 → XP_006537854.1 protein unc-13 homolog B isoform X10

Conserved Domains (6) summary

cd04027
Location:614 → 740

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1471 → 1590

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:492 → 541

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:932 → 1033

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1278 → 1414

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017320116.3 → XP_017175605.1 protein unc-13 homolog B isoform X12

Conserved Domains (6) summary

cd04027
Location:612 → 738

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1469 → 1588

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:490 → 539

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:930 → 1031

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1276 → 1412

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_036163973.1 → XP_036019866.1 protein unc-13 homolog B isoform X11

Conserved Domains (6) summary

cd04027
Location:613 → 739

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1470 → 1589

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:931 → 1034

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1277 → 1413

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:472 → 553

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_006537794.5 → XP_006537857.1 protein unc-13 homolog B isoform X15

Conserved Domains (6) summary

cd04027
Location:602 → 728

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1459 → 1578

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:480 → 529

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:920 → 1021

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1266 → 1402

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_006537795.5 → XP_006537858.1 protein unc-13 homolog B isoform X16

UniProtKB/TrEMBL

E9Q263

Related

ENSMUSP00000103587.3, ENSMUST00000107953.9

Conserved Domains (6) summary

cd04027
Location:600 → 726

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1457 → 1576

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:478 → 527

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:918 → 1019

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1264 → 1400

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_036163974.1 → XP_036019867.1 protein unc-13 homolog B isoform X13

Conserved Domains (6) summary

cd04027
Location:612 → 738

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1468 → 1587

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:930 → 1032

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1275 → 1411

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:471 → 552

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_036163976.1 → XP_036019869.1 protein unc-13 homolog B isoform X17

Conserved Domains (5) summary

cd04027
Location:520 → 646

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1377 → 1496

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:838 → 941

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1184 → 1320

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:379 → 460

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
XM_006537786.5 → XP_006537849.1 protein unc-13 homolog B isoform X1

Conserved Domains (6) summary

cd04027
Location:975 → 1101

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1832 → 1951

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:853 → 902

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1293 → 1394

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1639 → 1775

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_006537790.5 → XP_006537853.1 protein unc-13 homolog B isoform X5

Conserved Domains (6) summary

cd04027
Location:975 → 1101

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1813 → 1932

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:853 → 902

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1293 → 1394

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1639 → 1775

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_017320115.3 → XP_017175604.1 protein unc-13 homolog B isoform X1

Conserved Domains (6) summary

cd04027
Location:975 → 1101

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1832 → 1951

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:853 → 902

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1293 → 1394

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1639 → 1775

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_006537789.5 → XP_006537852.1 protein unc-13 homolog B isoform X3

UniProtKB/TrEMBL

A0A140LHX5

Related

ENSMUSP00000146589.2, ENSMUST00000207708.2

Conserved Domains (6) summary

cd04027
Location:973 → 1099

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1830 → 1949

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:851 → 900

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1291 → 1392

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1637 → 1773

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_006537788.5 → XP_006537851.1 protein unc-13 homolog B isoform X2

Conserved Domains (6) summary

cd04027
Location:975 → 1101

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1831 → 1950

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:853 → 902

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1293 → 1393

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1638 → 1774

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_036163969.1 → XP_036019862.1 protein unc-13 homolog B isoform X6

Conserved Domains (6) summary

cd04027
Location:975 → 1101

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1812 → 1931

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:1293 → 1395

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1638 → 1774

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:834 → 915

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_036163968.1 → XP_036019861.1 protein unc-13 homolog B isoform X4

Conserved Domains (6) summary

cd04027
Location:973 → 1099

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1829 → 1948

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:1291 → 1393

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1636 → 1772

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:832 → 913

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_036163970.1 → XP_036019863.1 protein unc-13 homolog B isoform X7

Conserved Domains (6) summary

cd04027
Location:973 → 1099

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1811 → 1930

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:1291 → 1394

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1637 → 1773

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:832 → 913

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins

cl09111
Location:139 → 219

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...