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Dpysl3 dihydropyrimidinase-like 3 [ Mus musculus (house mouse) ]

Gene ID: 22240, updated on 5-Mar-2024

Summary

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Official Symbol
Dpysl3provided by MGI
Official Full Name
dihydropyrimidinase-like 3provided by MGI
Primary source
MGI:MGI:1349762
See related
Ensembl:ENSMUSG00000024501 AllianceGenome:MGI:1349762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TUC4; Ulip; DRP-3; Ulip1; CRMP-4; ULIP-1
Summary
This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression
Biased expression in CNS E18 (RPKM 272.7), whole brain E14.5 (RPKM 195.1) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18; 18 B3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (43454044..43571354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (43320979..43438286, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44447 Neighboring gene predicted gene 8181 Neighboring gene STARR-seq mESC enhancer starr_44448 Neighboring gene STARR-seq mESC enhancer starr_44449 Neighboring gene serine/threonine kinase 32A Neighboring gene STARR-seq mESC enhancer starr_44450 Neighboring gene predicted gene, 31647 Neighboring gene STARR-seq mESC enhancer starr_44451 Neighboring gene predicted gene, 41714 Neighboring gene predicted gene 3650 Neighboring gene eukaryotic translation initiation factor 3, subunit J2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice. Minegishi Y, et al. Anticancer Res, 2022 Feb. PMID 35093877
  2. Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease. Li W, et al. Neurochem Res, 2020 Oct. PMID 32648145
  3. Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer. Yang Y, et al. Respir Res, 2018 Mar 7. PMID 29514686, Free PMC Article
  4. Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury. Nagai J, et al. Mol Cell Neurosci, 2016 Jul. PMID 26995506
  5. Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. Tonouchi A, et al. J Neurochem, 2016 Jun. PMID 26991935

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice.
    Title: CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice.
  2. CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
    Title: CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
  3. A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
    Title: A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
  4. Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
    Title: Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
  5. Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
    Title: Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
  6. Results found that Crmp4-KO mice have abnormalities that are relevant to some phenotypes of human autism spectrum disorders (ASD). Accumulating evidence suggests that a disturbance in the regulatory function of CRMP4 in forming neuronal networks is an important aspect underlying some characteristics of ASD, including sexual differences. These findings provide CRMP4 as a novel candidate gene contributing to ASD.
    Title: Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
  7. Knockdown of DPYSL3 promoted the metastatic ability of Lewis lung carcinoma cells.
    Title: Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer.
  8. findings identify CRMP4 as a novel negative regulator of osteoblast differentiation.
    Title: CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.
  9. Crmp4 deletion promotes axonal growth and nociceptive recovery after spinal cord injury.
    Title: Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.
  10. Results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.
    Title: CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables chondroitin sulfate binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables filamin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin crosslink formation ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dihydropyrimidinase-related protein 3
Names
collapsin response mediator protein 4
unc-33-like phosphoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136086.2 → NP_001129558.1  dihydropyrimidinase-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001129558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than CRMP4b.
    Source sequence(s)
    AC101718, AK133040, BQ175584
    Consensus CDS
    CCDS50269.1
    UniProtKB/TrEMBL
    Q3TT92
    Related
    ENSMUSP00000113711.2, ENSMUST00000118043.8
    Conserved Domains (2) summary
    PRK09060
    Location:15 → 465
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:15 → 469
    D-hydantoinase; D-hydantoinase

  2. NM_001291455.2 → NP_001278384.1  dihydropyrimidinase-related protein 3 isoform CRMP4b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (CRMP4b, also known as isoform 3).
    Source sequence(s)
    AC101718
    Consensus CDS
    CCDS79639.1
    UniProtKB/TrEMBL
    E9PWE8
    Related
    ENSMUSP00000112928.2, ENSMUST00000121805.9
    Conserved Domains (2) summary
    PRK09060
    Location:130 → 580
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:130 → 584
    D-hydantoinase; D-hydantoinase

  3. NM_009468.6 → NP_033494.1  dihydropyrimidinase-related protein 3 isoform CRMP4a

    See identical proteins and their annotated locations for NP_033494.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (CRMP4a, also known as isoform 2) has a distinct N-terminus and is shorter than CRMP4b.
    Source sequence(s)
    AC101718
    Consensus CDS
    CCDS37801.1
    UniProtKB/Swiss-Prot
    Q62188
    Related
    ENSMUSP00000025379.8, ENSMUST00000025379.14
    Conserved Domains (2) summary
    PRK09060
    Location:17 → 467
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:17 → 471
    D-hydantoinase; D-hydantoinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    43454044..43571354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62188.1 GenPept UniProtKB/Swiss-Prot:Q62188

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