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Ubp1 upstream binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22221, updated on 21-Apr-2024

Summary

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Official Symbol
Ubp1provided by MGI
Official Full Name
upstream binding protein 1provided by MGI
Primary source
MGI:MGI:104889
See related
Ensembl:ENSMUSG00000009741 AllianceGenome:MGI:104889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cp2b; NF2d9; LBP-1a; LBP-1b
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including aorta; early conceptus; genitourinary system; gut gland; and limb. Orthologous to human UBP1 (upstream binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 37.3), limb E14.5 (RPKM 35.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 64.14 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (113760002..113807095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (113930939..113978027)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CLIP associating protein 2 Neighboring gene predicted gene, 25059 Neighboring gene STARR-positive B cell enhancer ABC_E2309 Neighboring gene predicted gene, 39439 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene predicted gene, 36035 Neighboring gene STARR-seq mESC enhancer starr_25334 Neighboring gene predicted gene, 36883

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination. Repetny KJ, et al. Eur J Immunol, 2009 May. PMID 19384868, Free PMC Article
  2. Transactivation activity of LBP-1 proteins and their dimerization in living cells. Katsura A, et al. Genes Cells, 2009 Oct. PMID 19751393
  3. Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics. Koutnikova H, et al. PLoS Genet, 2009 Aug. PMID 19662162, Free PMC Article
  4. Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family. Kang HC, et al. Mol Cell Biol, 2005 Jul. PMID 15988015, Free PMC Article
  5. A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver. Sueyoshi T, et al. Mol Cell Biol, 1995 Aug. PMID 7623810, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBP1 is a critical blood pressure determinant using a combination of mouse and human genetics.
    Title: Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.
  2. These results demonstrate that LBP-1a plays a critical role in the regulation of extraembryonic angiogenesis.
    Title: Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
upstream-binding protein 1
Names
nuclear factor 2d9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083319.2 → NP_001076788.1  upstream-binding protein 1 isoform a

    See identical proteins and their annotated locations for NP_001076788.1

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    Consensus CDS
    CCDS40788.1
    UniProtKB/Swiss-Prot
    A4QPG4, Q3UPR3, Q3US11, Q60786, Q811S7, Q8C514
    UniProtKB/TrEMBL
    B2RUD2
    Related
    ENSMUSP00000081946.6, ENSMUST00000084885.12
    Conserved Domains (2) summary
    cd09588
    Location:369 → 435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  2. NM_001372507.1 → NP_001359436.1  upstream-binding protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    UniProtKB/Swiss-Prot
    A4QPG4, Q3UPR3, Q3US11, Q60786, Q811S7, Q8C514
    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:369 → 435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  3. NM_001372508.1 → NP_001359437.1  upstream-binding protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    UniProtKB/Swiss-Prot
    A4QPG4, Q3UPR3, Q3US11, Q60786, Q811S7, Q8C514
    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:369 → 435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  4. NM_001372510.1 → NP_001359439.1  upstream-binding protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    UniProtKB/Swiss-Prot
    A4QPG4, Q3UPR3, Q3US11, Q60786, Q811S7, Q8C514
    UniProtKB/TrEMBL
    B2RUD2
    Related
    ENSMUSP00000150023.2, ENSMUST00000216558.2
    Conserved Domains (2) summary
    cd09588
    Location:369 → 435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  5. NM_001372511.1 → NP_001359440.1  upstream-binding protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    UniProtKB/TrEMBL
    B2RUD2
    Related
    ENSMUSP00000149908.2, ENSMUST00000214095.2
    Conserved Domains (2) summary
    cd09588
    Location:333 → 399
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  6. NM_001372512.1 → NP_001359441.1  upstream-binding protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:333 → 399
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  7. NM_001372514.1 → NP_001359443.1  upstream-binding protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:333 → 399
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  8. NM_013699.3 → NP_038727.1  upstream-binding protein 1 isoform b

    See identical proteins and their annotated locations for NP_038727.1

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531
    Consensus CDS
    CCDS40789.1
    UniProtKB/TrEMBL
    B2RUD2
    Related
    ENSMUSP00000009885.8, ENSMUST00000009885.14
    Conserved Domains (2) summary
    cd09588
    Location:333 → 399
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

RNA

  1. NR_164181.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107803, CT025531

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    113760002..113807095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154842.1 → XP_036010735.1  upstream-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:333 → 399
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  2. XM_006512055.3 → XP_006512118.1  upstream-binding protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006512118.1

    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:369 → 435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:50 → 254
    CP2; CP2 transcription factor

  3. XM_006512050.5 → XP_006512113.3  upstream-binding protein 1 isoform X1

    Conserved Domains (2) summary
    cd09588
    Location:458 → 524
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:139 → 343
    CP2; CP2 transcription factor

  4. XM_006512052.5 → XP_006512115.3  upstream-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RUD2
    Conserved Domains (2) summary
    cd09588
    Location:422 → 488
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:139 → 343
    CP2; CP2 transcription factor

  5. XM_030244246.1 → XP_030100106.1  upstream-binding protein 1 isoform X7

    Related
    ENSMUST00000216891.2
    Conserved Domains (2) summary
    cd09588
    Location:181 → 247
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:2 → 102
    CP2; CP2 transcription factor

  6. XM_006512058.4 → XP_006512121.1  upstream-binding protein 1 isoform X5

    Conserved Domains (3) summary
    cd09588
    Location:217 → 283
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:2 → 102
    CP2; CP2 transcription factor
    pfam17061
    Location:135 → 197
    PARM

  7. XM_030244245.1 → XP_030100105.1  upstream-binding protein 1 isoform X6

    Conserved Domains (3) summary
    cd09588
    Location:217 → 283
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:2 → 102
    CP2; CP2 transcription factor
    pfam17061
    Location:135 → 197
    PARM

RNA

  1. XR_001778854.3 RNA Sequence

  2. XR_001778853.3 RNA Sequence

  3. XR_001778856.3 RNA Sequence

  4. XR_379864.5 RNA Sequence

  5. XR_001778855.3 RNA Sequence

  6. XR_001778857.3 RNA Sequence

  7. XR_001778852.3 RNA Sequence

  8. XR_001778858.3 RNA Sequence

  9. XR_004935386.1 RNA Sequence

  10. XR_004935387.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811S7.1 GenPept UniProtKB/Swiss-Prot:Q811S7

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