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Usp12 ubiquitin specific peptidase 12 [ Mus musculus (house mouse) ]

Gene ID: 22217, updated on 21-Apr-2024

Summary

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Official Symbol
Usp12provided by MGI
Official Full Name
ubiquitin specific peptidase 12provided by MGI
Primary source
MGI:MGI:1270128
See related
Ensembl:ENSMUSG00000029640 AllianceGenome:MGI:1270128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubh1
Summary
Enables deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; genitourinary system; and retina layer. Orthologous to human USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.4), large intestine adult (RPKM 10.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G3; 5 86.0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146671619..146731817, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146734809..146794956, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930573C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E11308 Neighboring gene predicted gene, 34700 Neighboring gene STARR-seq mESC enhancer starr_14850 Neighboring gene STARR-positive B cell enhancer ABC_E6401 Neighboring gene RIKEN cDNA 1700041I07 gene Neighboring gene STARR-seq mESC enhancer starr_14852 Neighboring gene STARR-positive B cell enhancer ABC_E6402 Neighboring gene STARR-positive B cell enhancer ABC_E6403 Neighboring gene predicted gene, 25091 Neighboring gene ribosomal protein L21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and complete cDNA sequence of UBH1 in mouse testis. Baek KH, et al. DNA Seq, 2002 Jun. PMID 12391724
  2. USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10. Fu Y, et al. Cell Death Differ, 2021 Oct. PMID 33941870, Free PMC Article
  3. USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity. Liu J, et al. PLoS Pathog, 2020 Jan. PMID 31899788, Free PMC Article
  4. Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα. Nayak TKS, et al. Biochem Biophys Res Commun, 2017 Jan 29. PMID 28063927
  5. USP12 promotes breast cancer angiogenesis by maintaining midkine stability. Sheng B, et al. Cell Death Dis, 2021 Nov 11. PMID 34759262, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP12 promotes breast cancer angiogenesis by maintaining midkine stability.
    Title: USP12 promotes breast cancer angiogenesis by maintaining midkine stability.
  2. USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10.
    Title: USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10.
  3. De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
    Title: De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
  4. cellular USP12 interacts with the HAT domain of CBP and inhibits CBP's acetyltransferase activity
    Title: USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
  5. Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
    Title: Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα.
  6. Product has deubiquitinating enzyme activity and sequence analysis showed 98.3% amino acid identity with human UBH1.
    Title: Molecular cloning and complete cDNA sequence of UBH1 in mouse testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 12
Names
deubiquitinating enzyme 12
ubiquitin specific protease 12
ubiquitin thioesterase 12
ubiquitin thiolesterase 12
ubiquitin-hydrolyzing enzyme 1
ubiquitin-specific-processing protease 12
NP_035799.1
XP_006504882.1
XP_030110225.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011669.3 → NP_035799.1  ubiquitin carboxyl-terminal hydrolase 12

    See identical proteins and their annotated locations for NP_035799.1

    Status: PROVISIONAL

    Source sequence(s)
    AC124828, AC127589
    Consensus CDS
    CCDS39395.1
    UniProtKB/Swiss-Prot
    Q790B0, Q7TNV4, Q80Y43, Q8CBN8, Q9D9M2
    Related
    ENSMUSP00000082754.6, ENSMUST00000085614.6
    Conserved Domains (2) summary
    cd02663
    Location:40 → 367
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:38 → 366
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146671619..146731817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254365.2 → XP_030110225.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X1

    Related
    ENSMUST00000138202.8
    Conserved Domains (1) summary
    cd02663
    Location:1 → 247
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_006504819.4 → XP_006504882.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X2

    Conserved Domains (1) summary
    cl02553
    Location:40 → 194
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9M2.2 GenPept UniProtKB/Swiss-Prot:Q9D9M2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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