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Ube2a ubiquitin-conjugating enzyme E2A [ Mus musculus (house mouse) ]

Gene ID: 22209, updated on 5-Mar-2024

Summary

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Official Symbol
Ube2aprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Aprovided by MGI
Primary source
MGI:MGI:102959
See related
Ensembl:ENSMUSG00000016308 AllianceGenome:MGI:102959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HR6A; HHR6A; Mhr6a
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Acts upstream of or within blastocyst hatching; maternal process involved in female pregnancy; and protein ubiquitination. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; female reproductive system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to human UBE2A (ubiquitin conjugating enzyme E2 A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.3), CNS E18 (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A3.3; X 21.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36137948..36147875)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36874295..36884222)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene mitochondrial dynamic related lncRNA Neighboring gene STARR-seq mESC enhancer starr_47006 Neighboring gene STING1 ER exit protein 1 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11047 Neighboring gene NF-kappaB repressing factor Neighboring gene predicted gene 15008 Neighboring gene septin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression. Bruinsma CF, et al. Hum Mol Genet, 2016 Jan 1. PMID 26476408
  2. Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Baarends WM, et al. Mol Cell Biol, 2003 Feb. PMID 12556476, Free PMC Article
  3. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice. Engel I, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12172006, Free PMC Article
  4. The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice. Roest HP, et al. Mol Cell Biol, 2004 Jun. PMID 15169909, Free PMC Article
  5. Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. Tateishi S, et al. Mol Cell Biol, 2003 Jan. PMID 12509447, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate a causal role of UBE2A in learning and mGLUR-dependent long-term depression
    Title: An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
  2. RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
    Title: RNF168 forms a functional complex with RAD6 during the DNA damage response.
  3. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.
    Title: Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.
  4. signaling through Notch modulates the turnover of E2A proteins
    Title: Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.
  5. absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage
    Title: The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maternal process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex ISO
Inferred from Sequence Orthology
more info
  
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 A
Names
E2 ubiquitin-conjugating enzyme A
RAD6 homolog A
ubiquitin carrier protein A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
ubiquitin-conjugating enzyme HR6A
ubiquitin-protein ligase A
NP_001300625.1
NP_062642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313696.1 → NP_001300625.1  ubiquitin-conjugating enzyme E2 A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA013850, AK163966, AK164074, BE994531
    Consensus CDS
    CCDS85765.1
    UniProtKB/TrEMBL
    Q3TQ27, Q3TUV9
    Related
    ENSMUSP00000144242.2, ENSMUST00000202991.4
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 142
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_019668.4 → NP_062642.1  ubiquitin-conjugating enzyme E2 A isoform 1

    See identical proteins and their annotated locations for NP_062642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA013850, AK164074, BE994531
    Consensus CDS
    CCDS30064.1
    UniProtKB/Swiss-Prot
    Q9Z255
    UniProtKB/TrEMBL
    Q3TUV9, Q3UCS1
    Related
    ENSMUSP00000016452.8, ENSMUST00000016452.11
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 145
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36137948..36147875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z255.1 GenPept UniProtKB/Swiss-Prot:Q9Z255

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