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Ube2i ubiquitin-conjugating enzyme E2I [ Mus musculus (house mouse) ]

Gene ID: 22196, updated on 21-Apr-2024

Summary

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Official Symbol
Ube2iprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Iprovided by MGI
Primary source
MGI:MGI:107365
See related
Ensembl:ENSMUSG00000015120 AllianceGenome:MGI:107365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBC9; Ubce9; Ubce2i; 5830467E05Rik
Summary
Enables HLH domain binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in nuclear body. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 68.8), whole brain E14.5 (RPKM 68.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25479484..25494965, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25260510..25275799, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34 Neighboring gene predicted gene, 25921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ube2i deletion in adipocytes causes lipoatrophy in mice. Cox AR, et al. Mol Metab, 2021 Jun. PMID 33771728, Free PMC Article
  2. Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis. Kumar R, et al. J Immunol, 2021 Mar 1. PMID 33504619, Free PMC Article
  3. The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models. Verma DK, et al. eNeuro, 2020 Sep/Oct. PMID 32887693, Free PMC Article
  4. Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice. Rodriguez A, et al. Development, 2019 Dec 2. PMID 31704792, Free PMC Article
  5. Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis. Edrees MAH, et al. Mol Immunol, 2019 Oct. PMID 31442915

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubc9 regulates the expression of MHC II in dendritic cells to enhance DSS-induced colitis by mediating RBPJ SUMOylation.
    Title: Ubc9 regulates the expression of MHC II in dendritic cells to enhance DSS-induced colitis by mediating RBPJ SUMOylation.
  2. UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer.
    Title: UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer.
  3. Ube2i deletion in adipocytes causes lipoatrophy in mice.
    Title: Ube2i deletion in adipocytes causes lipoatrophy in mice.
  4. T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-theta-mediated phosphorylation of RanGAP1.
    Title: T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.
  5. Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
    Title: Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
  6. Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis.
    Title: Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis.
  7. The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of alpha-Synuclein in Parkinson's Disease Models.
    Title: The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.
  8. An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency.
    Title: An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency.
  9. Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
    Title: Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
  10. Transcriptomic profiling of ovaries suggests that loss of oocyte Ube2i caused defects in both oocyte- and granulosa cell-expressed genes, including NOBOX and some of its known target genes.
    Title: Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables HLH domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RING-like zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export EXP
Inferred from Experiment
more info
 PubMed 
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of SUMO ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SUMO ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SUMO-conjugating enzyme UBC9
Names
RING-type E3 SUMO transferase UBC9
SUMO-protein ligase
ubiquitin carrier protein 9
ubiquitin carrier protein I
ubiquitin-protein ligase I
NP_001171080.1
NP_001171081.1
NP_001344623.1
NP_035795.1
XP_006524112.1
XP_036016378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177609.1 → NP_001171080.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_001171080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK150575, AK166657, AK166930
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    Related
    ENSMUSP00000134261.2, ENSMUST00000173084.9
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001177610.1 → NP_001171081.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_001171081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC122454, AK166930
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    Related
    ENSMUSP00000134350.2, ENSMUST00000174031.9
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_001357694.1 → NP_001344623.1  SUMO-conjugating enzyme UBC9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC122454, CD776278
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    Related
    ENSMUSP00000134161.3, ENSMUST00000173621.9
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  4. NM_011665.4 → NP_035795.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_035795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK005058, BY074880
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    Related
    ENSMUSP00000134491.2, ENSMUST00000173713.9
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25479484..25494965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524049.5 → XP_006524112.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_006524112.1

    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    Related
    ENSMUSP00000055714.10, ENSMUST00000049911.17
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  2. XM_036160485.1 → XP_036016378.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    Related
    ENSMUSP00000159860.1, ENSMUST00000249684.1
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63280.1 GenPept UniProtKB/Swiss-Prot:P63280

Gene LinkOut

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