Ubb ubiquitin B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubbprovided by MGI
Official Full Name: ubiquitin Bprovided by MGI
Primary source: MGI:MGI:98888
See related: Ensembl:ENSMUSG00000019505 AllianceGenome:MGI:98888
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ubc; Ubb2; Uba52; Rps27a
Summary: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in testis adult (RPKM 2757.3), whole brain E14.5 (RPKM 1808.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 38.46 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (62442329..62444037)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (62551171..62553213)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of the polyubiquitin gene Ubb reduces the self-renewal capacity of neural stem cells.
Title: Disruption of the polyubiquitin gene Ubb reduces the self-renewal capacity of neural stem cells.
The thickness of the outer nuclear layer of the retina was decreased in Ubb knockout mice compared to control mice, suggesting that retinal degeneration was induced by Ub deficiency.
Title: Disruption of the polyubiquitin gene Ubb causes retinal degeneration in mice.
Ubb plays a pivotal role in neural stem cell differentiation to suppress Notch signaling, but not in the subsequent maturation stages of neurons that had already been differentiated.
Title: Temporal downregulation of the polyubiquitin gene Ubb affects neuronal differentiation, but not maturation, in cells cultured in vitro.
that UBB(+1) is specifically expressed in a subset of parasagittal stripes of Purkinje cells in the cerebellar cortex of a UBB(+1)-expressing mouse model
Title: Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum.
Data indicate that levels of repressor element-1 silencing transcription factor (REST) are elevated in polyubiquitin-B knockout (Ubb -/-) cells.
Title: Regulation of REST levels overcomes dysregulation of neural stem cell differentiation caused by disruption of polyubiquitin gene Ubb.
Ubb deficiency causes dysregulation of neural stem cell differentiation with premature gliogenesis.
Title: Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis.
study suggests that Ub homeostasis, or the maintenance of cellular free Ub above certain threshold levels, is essential for proper neuronal development and survival
Title: Restoration of cellular ubiquitin reverses impairments in neuronal development caused by disruption of the polyubiquitin gene Ubb.
The lysine 6 to tryptophan ubiquitin substitution results in the cataract development in newborn mice.
Title: Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin.
upon stress induced by disruption of Ubb, neuronal vulnerability may be determined based on the ability of neurons or neighboring cells to maintain free Ub levels for the protection of neuronal function and survival.
Title: Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.
Several genes related to fertility, metabolism, transcription, and the ubiquitin-proteasome system (UPS) are misregulated in Ubb (-/-)testes at 7 and/or 14 days. In Ubb (-/-)testes ubiquitylated levels of histone H2A are significantly reduced.
Title: Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ubb (e-PCR), detects polymorphism
- UniSTS:546572

D17950 (e-PCR)
- UniSTS:124748

D2S1561E (e-PCR)
- UniSTS:150646

39082591 (e-PCR)
- UniSTS:498050

Ubc (e-PCR), detects polymorphism
- UniSTS:532466

RH124192 (e-PCR)
- UniSTS:161014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypothalamus gonadotrophin-releasing hormone neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion transport along microtubule	ISO Inferred from Sequence Orthology more info	PubMed
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: polyubiquitin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313984.2 → NP_001300913.1 polyubiquitin-B precursor

Status: VALIDATED

Source sequence(s)

AL596181

Consensus CDS

CCDS24826.1

UniProtKB/Swiss-Prot

P0CG49

UniProtKB/TrEMBL

Q78XY9, Q8R0Z9

Conserved Domains (1) summary

cd01803
Location:77 → 152

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
NM_011664.5 → NP_035794.1 polyubiquitin-B precursor

See identical proteins and their annotated locations for NP_035794.1

Status: VALIDATED

Source sequence(s)

AL596181

Consensus CDS

CCDS24826.1

UniProtKB/Swiss-Prot

P0CG49

UniProtKB/TrEMBL

Q78XY9, Q8R0Z9

Related

ENSMUSP00000019649.4, ENSMUST00000019649.4

Conserved Domains (1) summary

cd01803
Location:77 → 152

Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin